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Evaluation of real-life outcome data of patients with spinal muscular atrophy treated with nusinersen in Switzerland. ...
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Proportionate translation of study materials and measures in a multinational global health trial: methodology development and implementation ...
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The Terms of “You(s)”: How the Term of Address Used by Conversational Agents Influences User Evaluations in French and German Linguaculture ...
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Prävalenz von Hörstörungen bei Patienten mit rheumatoider Arthritis und Granulomatose mit Polyangiitis ...
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Pilotstudie zur parodontalen Gesundheit bei Patienten mit frontotemporaler Demenz ...
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R-Loops und replikativer Stress als Angriffspunkt für eine zielgerichtete Therapie beim Myelodysplastischen Syndrom
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Speech Perception in Bilateral Hearing Aid Users With Different Grades of Asymmetric Hearing Loss
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Mindfulness Training in Dialectical Behavior Therapy Investigation on Brain Activity by NIRS ...
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Exploring how Syrian women manage their health after migration to Germany: results of a qualitative study ...
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Tooth Malformations, DMFT Index, Speech Impairment and Oral Habits in Patients with Fetal Alcohol Syndrome
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Orthografische Verarbeitung bei Kindern mit Lese- und/oder Rechtschreibstörung: Neurophysiologische Korrelate und Lernprozesse
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The clinical relevance of formal thought disorder in the early stages of psychosis: results from the PRONIA study
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Öztürk, Ömer Faruk; Pigoni, Alessandro; Wenzel, Julian; Haas, Shalaila S.; Popovic, David; Ruef, Anne; Dwyer, Dominic B.; Kambeitz-Ilankovic, Lana; Ruhrmann, Stephan; Chisholm, Katharine; Lalousis, Paris; Griffiths, Sian Lowri; Lichtenstein, Theresa; Rosen, Marlene; Kambeitz, Joseph; Schultze-Lutter, Frauke; Liddle, Peter; Upthegrove, Rachel; Salokangas, Raimo K. R.; Pantelis, Christos; Meisenzahl, Eva; Wood, Stephen J.; Brambilla, Paolo; Borgwardt, Stefan; Falkai, Peter; Antonucci, Linda A.; Koutsouleris, Nikolaos
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In: European archives of psychiatry and clinical neuroscience (2021)
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Abstract:
BACKGROUND Formal thought disorder (FTD) has been associated with more severe illness courses and functional deficits in patients with psychotic disorders. However, it remains unclear whether the presence of FTD characterises a specific subgroup of patients showing more prominent illness severity, neurocognitive and functional impairments. This study aimed to identify stable and generalizable FTD-subgroups of patients with recent-onset psychosis (ROP) by applying a comprehensive data-driven clustering approach and to test the validity of these subgroups by assessing associations between this FTD-related stratification, social and occupational functioning, and neurocognition. METHODS 279 patients with ROP were recruited as part of the multi-site European PRONIA study (Personalised Prognostic Tools for Early Psychosis Management; www.pronia.eu). Five FTD-related symptoms (conceptual disorganization, poverty of content of speech, difficulty in abstract thinking, increased latency of response and poverty of speech) were assessed with Positive and Negative Symptom Scale (PANSS) and the Scale for the Assessment of Negative Symptoms (SANS). RESULTS The results with two patient subgroups showing different levels of FTD were the most stable and generalizable clustering solution (predicted clustering strength value~=~0.86). FTD-High subgroup had lower scores in social (pfdr < 0.001) and role (pfdr~< 0.001) functioning, as well as worse neurocognitive performance in semantic (pfdr < 0.001) and phonological verbal fluency (pfdr~< 0.001), short-term verbal memory (pfdr~=~0.002) and abstract thinking (pfdr~=~0.010), in comparison to FTD-Low group. CONCLUSIONS Clustering techniques allowed us to identify patients with more pronounced FTD showing more severe deficits in functioning and neurocognition, thus suggesting that FTD may be a relevant marker of illness severity in the early psychosis pathway.
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Keyword:
ddc:610; Medizin
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URL: http://nbn-resolving.de/urn:nbn:de:bvb:19-epub-90850-3
https://doi.org/10.1007/s00406-021-01327-y
https://epub.ub.uni-muenchen.de/90850/1/Oeztuerk2021_Article_TheClinicalRelevanceOfFormalTh.pdf
https://epub.ub.uni-muenchen.de/90850/
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Exploring how Syrian women manage their health after migration to Germany: results of a qualitative study ...
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Exploring how Syrian women manage their health after migration to Germany: results of a qualitative study ...
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A rare disease patient-reported outcome measure: revision and validation of the German version of the Systemic Sclerosis Quality of Life Questionnaire (SScQoL) using the Rasch model. ...
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Oral diadochokinesis and associated oro-facial function in young and old German mother-tongue speakers: A cross-sectional study. ...
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Monitoring the health and healthcare provision for refugees in collective accommodation centres: Results of the populationbased survey RESPOND ...
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Neurocognitive course at two-year follow-up in the neurocognitive assessment in the metabolic and aging cohort (NAMACO) study. ...
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Alcohol consumption and neurocognitive deficits in people with well-treated HIV in Switzerland. ...
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Using a cochlear implant processor as contralateral routing of signals device in unilateral cochlear implant recipients ...
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