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Development of a standard of care for patients with valosin-containing protein associated multisystem proteinopathy.
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In: Orphanet journal of rare diseases, vol 17, iss 1 (2022)
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Cortical microstructure in primary progressive aphasia: a multicenter study.
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In: Alzheimer's research & therapy, vol 14, iss 1 (2022)
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Computational Models in Electroencephalography.
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In: Brain topography, vol 35, iss 1 (2022)
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Analysis of ancestry heterozygosity suggests that hybrid incompatibilities in threespine stickleback are environment dependent.
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Thompson, Ken A; Peichel, Catherine L; Rennison, Diana J; McGee, Matthew D; Albert, Arianne YK; Vines, Timothy H; Greenwood, Anna K; Wark, Abigail R; Brandvain, Yaniv; Schumer, Molly; Schluter, Dolph
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In: PLoS biology, vol 20, iss 1 (2022)
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Abstract:
Hybrid incompatibilities occur when interactions between opposite ancestry alleles at different loci reduce the fitness of hybrids. Most work on incompatibilities has focused on those that are "intrinsic," meaning they affect viability and sterility in the laboratory. Theory predicts that ecological selection can also underlie hybrid incompatibilities, but tests of this hypothesis using sequence data are scarce. In this article, we compiled genetic data for F2 hybrid crosses between divergent populations of threespine stickleback fish (Gasterosteus aculeatus L.) that were born and raised in either the field (seminatural experimental ponds) or the laboratory (aquaria). Because selection against incompatibilities results in elevated ancestry heterozygosity, we tested the prediction that ancestry heterozygosity will be higher in pond-raised fish compared to those raised in aquaria. We found that ancestry heterozygosity was elevated by approximately 3% in crosses raised in ponds compared to those raised in aquaria. Additional analyses support a phenotypic basis for incompatibility and suggest that environment-specific single-locus heterozygote advantage is not the cause of selection on ancestry heterozygosity. Our study provides evidence that, in stickleback, a coarse-albeit indirect-signal of environment-dependent hybrid incompatibility is reliably detectable and suggests that extrinsic incompatibilities can evolve before intrinsic incompatibilities.
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Keyword:
Agricultural and Veterinary Sciences; Biological Sciences; Developmental Biology; Genetics; Medical and Health Sciences
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URL: https://escholarship.org/uc/item/3f26386d
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Genetic continuity of Indo-Iranian speakers since the Iron Age in southern Central Asia
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In: ISSN: 2045-2322 ; EISSN: 2045-2322 ; Scientific Reports ; https://hal.archives-ouvertes.fr/hal-03566556 ; Scientific Reports, Nature Publishing Group, 2022, 12, pp.733. ⟨10.1038/s41598-021-04144-4⟩ (2022)
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‘Making the most of together time’: development of a Health Visitor–led intervention to support children’s early language and communication development at the 2–2½-year-old review ...
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Molecular brain (micro report) oxytocin ameliorates impaired social behavior in a mouse model of 3q29 deletion syndrome ...
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Moderators and predictors in a parent hearing aid management eHealth program ...
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Molecular brain (micro report) oxytocin ameliorates impaired social behavior in a mouse model of 3q29 deletion syndrome ...
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Moderators and predictors in a parent hearing aid management eHealth program ...
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‘Making the most of together time’: development of a Health Visitor–led intervention to support children’s early language and communication development at the 2–2½-year-old review ...
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Supplemental Materials from Long-range sequential dependencies precede complex syntactic production in language acquisition ...
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Supplemental Materials from Long-range sequential dependencies precede complex syntactic production in language acquisition ...
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Investigating the Folk Concept of Pain: Implication & Projection ...
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Locality and attachment preferences in preverbal versus post-verbal Relative Clauses ...
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Locality and attachment preferences in preverbal versus post-verbal Relative Clauses ...
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Nasal rustle perception without secretion bubbling (Oren et al., 2022) ...
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Nasal rustle perception without secretion bubbling (Oren et al., 2022) ...
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