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Efficient localization of the cortical language network and its functional neuroanatomy in dyslexia
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Abstract:
The functional neuroanatomy of language localization in dyslexia has primarily been studied in the context of reading. However, dyslexia is sometimes referred to as a “language-based learning disability,” yet the functional signature of the core language comprehension network in dyslexia is far less understood. This thesis presents a series of studies designed to compare the functionality of the brain regions supporting linguistic processing between typical and impaired readers in order to characterize the cortical language network in dyslexia. First, we investigate the extent to which the efficiency (or quality of data vs. amount of scan time) of a functional language localizer based on passive spoken language comprehension can be maximized in Chapter 2. By demarcating the language network based on smaller amounts of data and testing stability and reliability within this framework, we found that scan time can be substantially reduced without sacrificing functional specialization for language. In Chapter 3, we apply the spoken language localizer to determine differences in functional organization of language in dyslexia and provide evidence that the core spoken language comprehension network is not markedly different between typical readers and those with dyslexia. We compared the individual activations from whole-brain analysis and functional profiles in the canonical language-selective regions and found that the functional response of localized language regions in individuals with dyslexia was as selective as in typically reading adults. Chapter 4 follows up on the functional evidence reported in Chapter 3 to examine the structural connectivity within the same functional language network and additionally found essentially no differences between controls and dyslexia, further supporting the observations made in Chapter 3 that core linguistic processing is intact in dyslexia. All together, these findings converge on the suggestion that individuals with dyslexia do not rely on a separate cognitive architecture for language, potentially revealing important new insight into the dissociation of language specialization abilities and reading difficulty in dyslexia.
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Keyword:
Cognition; DWI; fMRI; Language; Neuroimaging; Speech; Test-retest reliability
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URL: https://hdl.handle.net/2144/43724
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| 2 |
Mapping of Language-and-Memory Networks in Patients With Temporal Lobe Epilepsy by Using the GE2REC Protocol
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In: ISSN: 1662-5161 ; Frontiers in Human Neuroscience ; https://hal-cnrs.archives-ouvertes.fr/hal-03529823 ; Frontiers in Human Neuroscience, Frontiers, 2022, 15, ⟨10.3389/fnhum.2021.752138⟩ (2022)
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| 3 |
Reading in the Developing Brain ... : From Preliteracy to Fluent Reading ...
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| 4 |
Phonological and semantic specialization in 9- to 10-year-old children during auditory word processing ...
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| 5 |
Data for: Speech naturalness detection and language representation in the dog brain ...
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| 6 |
Data for: Speech naturalness detection and language representation in the dog brain ...
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| 7 |
Behavioral and neural correlates of speech motor sequence learning in stuttering and neurotypical speakers: an fMRI investigation
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| 8 |
Resting-State Functional Connectivity following Phonological Component Analysis: The Combined Action of Phonology and Visual Orthographic Cues
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In: ISSN: 2076-3425 ; Brain Sciences ; https://hal.uca.fr/hal-03474243 ; Brain Sciences, MDPI, 2021, 11, pp.1458. ⟨10.3390/brainsci11111458⟩ (2021)
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| 9 |
Cerebellar and Cortical Correlates of Internal and External Speech Error Monitoring
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In: ISSN: 2632-7376 ; EISSN: 2632-7376 ; Cerebral Cortex Communications ; https://hal.archives-ouvertes.fr/hal-03340216 ; Cerebral Cortex Communications, Oxford University Press, 2021, 2, ⟨10.1093/texcom/tgab038⟩ (2021)
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| 10 |
Overt speech critically changes lateralization index and did not allow determination of hemispheric dominance for language: an fMRI study
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In: ISSN: 1471-2202 ; EISSN: 1471-2202 ; BMC Neuroscience ; https://www.hal.inserm.fr/inserm-03474160 ; BMC Neuroscience, BioMed Central, 2021, 22 (1), pp.74. ⟨10.1186/s12868-021-00671-y⟩ (2021)
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| 11 |
Language distance in orthographic transparency affects cross-language pattern similarity between native and non-native languages.
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In: Human brain mapping, vol 42, iss 4 (2021)
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| 12 |
An exploration of amygdala-prefrontal mechanisms in the intergenerational transmission of learned fear.
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In: Developmental science, vol 24, iss 3 (2021)
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| 13 |
Interactive mapping of language and memory with the GE2REC protocol
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In: ISSN: 1931-7557 ; EISSN: 1931-7565 ; Brain imaging and behavior (Brain Imaging Behav) ; https://hal.univ-grenoble-alpes.fr/hal-03091631 ; Brain imaging and behavior (Brain Imaging Behav), Secaucus, NJ : Springer, In press, ⟨10.1007/s11682-020-00355-x⟩ (2021)
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| 14 |
Neural processing of vision and language in kindergarten is associated with prereading skills and predicts future literacy
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In: ISSN: 1065-9471 ; EISSN: 1097-0193 ; Human Brain Mapping ; https://hal-amu.archives-ouvertes.fr/hal-03217489 ; Human Brain Mapping, Wiley, 2021, ⟨10.1002/hbm.25449⟩ (2021)
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| 15 |
Multimodal neural networks better explain multivoxel patterns in the hippocampus
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In: Neural Information Processing Systems (NeurIPS) conference: 3rd Workshop on Shared Visual Representations in Human and Machine Intelligence (SVRHM 2021) ; https://hal.archives-ouvertes.fr/hal-03428635 ; Neural Information Processing Systems (NeurIPS) conference: 3rd Workshop on Shared Visual Representations in Human and Machine Intelligence (SVRHM 2021), Dec 2021, Virtual Conference, United States ; https://openreview.net/forum?id=6dymbuga7nL (2021)
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| 16 |
Neural processing of vision and language in kindergarten is associated with prereading skills and predicts future literacy ...
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| 17 |
Functional neuroanatomy of language without speech: An ALE meta-analysis of sign language ...
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| 18 |
Neural competition between concurrent speech production and other speech perception ...
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| 19 |
Selective modulation of interhemispheric connectivity by transcranial alternating current stimulation influences binaural integration ...
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| 20 |
Engagement of Language and Domain General Networks during Word Monitoring in a Native and Unknown Language
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In: Brain Sciences ; Volume 11 ; Issue 8 (2021)
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