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Language learning experience and mastering the challenges of perceiving speech in noise
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In: https://www.sciencedirect.com/journal/brain-and-language/vol/196/suppl/C (2019)
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Emerging neural specialization of the ventral occipitotemporal cortex to characters through phonological association learning in preschool children ...
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Action and object words are differentially anchored in the sensory motor system - a perspective on cognitive embodiment ...
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Narratives: fMRI data for evaluating models of naturalistic language comprehension ...
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Narratives: fMRI data for evaluating models of naturalistic language comprehension ...
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Emerging neural specialization of the ventral occipitotemporal cortex to characters through phonological association learning in preschool children
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In: NeuroImage, 189 (2019)
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Depth of Encoding Through Observed Gestures in Foreign Language Word Learning
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Representational Geometry of categorical perception of animate and inanimate objects
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Seyfried, Friederike. - : Justus-Liebig-Universität Gießen, 2019. : FB 06 - Psychologie und Sportwissenschaft. Psychologie und Sportwissenschaft fachübergreifend, 2019
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A systematic review of brain imaging studies of semantic priming ; Revisão sistemática de estudos de neuroimagem do priming semântico
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Motor and language resting state functional magnetic resonance imaging in brain tumor patients
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Abstract:
Background and purpose: Resting state functional magnetic resonance (RS-fMRI) correlation with pre-surgical functional status in patients with brain tumors is scarcely documented in the present literature. Aim of the present study was to investigate the validity of RS-fMRI as potential preoperative functional mapping tool in tumor brain surgery by exploring the association of motor and language RS-fMRI networks with subjects’ preoperative performance on motor and language clinical assessment respectively in patients with brain tumor. Materials and methods: 85 patients presented with brain tumor entities and 27 healthy controls were prospectively recruited for the present study. Clinical sample was subdivided into two groups according to mass localization: patients with tumors in proximity to motor cortex (n=59) underwent clinical examination for gross (paresis- muscle weakness) and fine (finger tapping) motor deficits. Patients harboring tumors in proximity to the left inferior frontal gyrus (n=35) were clinically assessed for apparent (expressive aphasia) and subtle language function (phonological verbal fluency) disturbances. All patients and healthy subjects underwent RS-fMRI with motor and language resting networks being derived by Independent Component Analysis (ICA). Results: In the motor group, patients with paresis demonstrated significantly (p=<0.01) reduced resting state BOLD-signal intensity in ipsilesional motor cortex in comparison to the respective one in contralesional-intact motor cortex. Significantly (p<0.01) decreased BOLD-signal intensity was additionally noticed in ipsilesional motor cortex of patients with paresis in comparison to patients with normal muscle strength. Furthermore, in patients with intact muscle strength, a strong positive correlation (r=0.70, p<0.01) between ipsilesional pre-central gyrus BOLD-signal and performance on finger tapping task was demonstrated. Compared to the healthy group, clinical motor group showed reduced resting state network activity, with patients’ ipsilesional pre- central gyrus BOLD-signal intensity to be significantly (p<0.01) lower than normals’ left and right pre-central gyri BOLD-signal intensities. Concerning language group, patients presented with expressive aphasia exhibited significantly (p=<0.01) reduced RS-fMRI BOLD-signal intensity in left inferior frontal gyrus (Broadmann area 44) when compared with patients without aphasia. In non-aphasic patients, a strong positive correlation (r=0.70, P<0.01) between left inferior frontal gyrus’ BOLD-signal intensity and phonological fluency scoring was demonstrated. Similarly with the motor group, language group also showed significantly (p=<0.01) reduced left inferior gyrus RS- fMRI BOLD-signal when compared to healthy controls. Finally, RS-fMRI BOLD signal was not observed to have an association with demographic parameters (age, gender) for both clinical and healthy groups and with tumor histopathological grading for both motor and language clinical groups. Conclusions: Our findings show a significant affection of motor and language RS-fMRI networks’ BOLD-signal intensity by the presence of a tumor and a correlation with clinical performance of patients providing thus evidence for the functional validity of RS-fMRI in brain tumor patients; our results indicate therefore, that RS-fMRI may be a valuable complementary tool for preoperative mapping of eloquent areas, at least in patients who cannot cooperate satisfactory in a traditional task-based motor and language fMRI.
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Keyword:
610; funktionelle Magnetresonanztomographie im Ruhezustand; Gehirn; language; motor; resting state fmri; Tumor
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URL: http://hdl.handle.net/10900/91055 http://nbn-resolving.de/urn:nbn:de:bsz:21-dspace-910557 https://doi.org/10.15496/publikation-32436
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Characterizing the Familiar-Voice Benefit to Intelligibility
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In: Electronic Thesis and Dissertation Repository (2019)
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Sign and Speech Share Partially Overlapping Conceptual Representations
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In: Brain and Mind Institute Researchers' Publications (2019)
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Relación entre destreza musical y lateralización derecha del lenguaje en población zurda
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Relating Conceptual Structure With Flexible Concept Use
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In: Publicly Accessible Penn Dissertations (2019)
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Neuroimaging 'will to fight' for sacred values: An empirical case study with supporters of an Al Qaeda associate
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Functional correlates of strategy formation and verbal suppression in Parkinson's disease
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Neural mechanisms for monitoring and halting of spoken word production
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