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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Hits 1 – 15 of 15 1 Pleiotropy between language impairment and broader behavioral disorders—an investigation of both common and rare genetic variants ... Nudel, Ron; Appadurai, Vivek; Buil, Alfonso. - : figshare, 2021 BASE Show details 2 Pleiotropy between language impairment and broader behavioral disorders—an investigation of both common and rare genetic variants ... Nudel, Ron; Appadurai, Vivek; Buil, Alfonso. - : figshare, 2021 BASE Show details 3 Pleiotropy between language impairment and broader behavioral disorders—an investigation of both common and rare genetic variants Nudel, Ron; Appadurai, Vivek; Buil, Alfonso... In: J Neurodev Disord (2021) BASE Show details 4 Quantitative genome-wide association analyses of receptive language in the Danish High Risk and Resilience Study ... Nudel, Ron; Christiani, Camilla A. J.; Ohland, Jessica. - : figshare, 2020 BASE Show details 5 Quantitative genome-wide association analyses of receptive language in the Danish High Risk and Resilience Study ... Nudel, Ron; Christiani, Camilla A. J.; Ohland, Jessica. - : figshare, 2020 BASE Show details 6 Quantitative genome-wide association analyses of receptive language in the Danish High Risk and Resilience Study Nudel, Ron; Christiani, Camilla A. J.; Ohland, Jessica... In: BMC Neurosci (2020) BASE Show details 7 Language deficits in specific language impairment, attention deficit/hyperactivity disorder, and autism spectrum disorder: An analysis of polygenic risk Nudel, Ron; Christiani, Camilla A. J.; Ohland, Jessica. - : John Wiley & Sons, Inc., 2019 BASE Show details 8 Further evidence for a parent-of-origin effect at the NOP9 locus on language-related phenotypes Pettigrew, Kerry A; Frinton, Emily; Nudel, Ron. - 2016 BASE Show details 9 Further evidence for a parent-of-origin effect at the NOP9 locus on language-related phenotypes Pettigrew, Kerry Andrea; Frinton, Emily; Nudel, Ron; Chan, May T. M.; Thompson, Paul; Hayiou-Thomas, Marianna E.; Talcott, Joel B.; Stein, John; Monaco, Anthony P.; Hulme, Charles; Snowling, Margaret J.; Newbury, Diane F.; Paracchini, Silvia. - 2016 Abstract: SP is a Royal Society University Research Fellow. Support to the analysis was provided by the St Andrews Bioinformatics Unit funded by the Wellcome Trust [grant 097831/Z/11/Z]. Analysis of the cohort was supported by a Wellcome Trust Programme Grant to MJS [WT082032MA]. EF is the recipient of a Wolfson Intercalated Award. MTMC is the recipient of the Wilkinson Junior Research Fellowship at Worcester College, Oxford and was funded by the Esther Yewpick Lee Millennium Scholarship. RN was funded by a University of Oxford Nuffield Department of Medicine Prize Studentship. DFN is an MRC Career Development Fellow. The work of the Newbury lab is funded by the Medical Research Council [G1000569/1 and MR/J003719/1]. The work of the Wellcome Trust Centre in Oxford is supported by the Wellcome Trust [090532/Z/09/Z]. ; Background: Specific Language Impairment (SLI) is a common neurodevelopmental disorder, observed in 5-10% of children. Family and twin studies suggest a strong genetic component, but relatively few candidate genes have been reported to date. A recent genome-wide association study (GWAS) described the first statistically significant association specifically for a SLI cohort between a missense variant (rs4280164) in the NOP9 gene and language-related phenotypes under a parent-of-origin model. Replications of these findings are particularly challenging because the availability of parental DNA is required. Methods: We used two independent family-based cohorts characterised with reading- and language-related traits: a longitudinal cohort (n = 106 informative families) including children with language and reading difficulties and a nuclear family cohort (n = 264 families) selected for dyslexia. Results: We observed association with languagerelated measures when modelling for parent-of-origin effects at the NOP9 locus in both cohorts: minimum P = 0.001 for phonological awareness with a paternal effect in the first cohort and minimum P = 0.0004 for irregular word reading with a maternal effect in the second cohort. Allelic and parental trends were not consistent when compared to the original study. Conclusions: A parent-of-origin effect at this locus was detected in both cohorts, albeit with different trends. These findings contribute in interpreting the original GWAS report and support further investigations of the NOP9 locus and its role in language-related traits. A systematic evaluation of parent-of-origin effects in genetic association studies has the potential to reveal novel mechanisms underlying complex traits. ; Publisher PDF ; Peer reviewed Keyword: Candidate gene; Dyslexia; Genetic association; Language impairement; NDAS; Parent-of-origin; RC0321; RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry URL: http://hdl.handle.net/10023/8991 https://doi.org/10.1186/s11689-016-9157-6 BASE Hide details 10 Further evidence for a parent-of-origin effect at the NOP9 locus on language-related phenotypes Pettigrew, Kerry A.; Frinton, Emily; Nudel, Ron. - 2016 BASE Show details 11 Further evidence for a parent-of-origin effect at the NOP9 locus on language-related phenotypes Pettigrew, Kerry A.; Frinton, Emily; Nudel, Ron. - : BioMed Central Ltd., 2016 BASE Show details 12 <The>> genetics of specific language impairment Nudel, Ron; Ceroni, Fabiola; Simpson, Nuala H.... In: Specific language impairment (Amsterdam, 2015), p. 7-34 MPI für Psycholinguistik Show details 13 Genome-wide association analyses of child genotype effects and parent-of-origin effects in specific language impairment Nudel, Ron; Simpson, Nuala H; Baird, Gillian. - 2015 BASE Show details 14 Associations of HLA alleles with specific language impairment Nudel, Ron; Simpson, Nuala H; Baird, Gillian. - : BioMed Central, 2014 BASE Show details 15 Associations of HLA alleles with specific language impairment Nudel, Ron; Simpson, Nuala H; Baird, Gillian. - 2014 BASE Show details

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