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Examining the presence and nature of delusions in Alzheimer's disease and frontotemporal dementia syndromes
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2
Evidence for a pervasive autobiographical memory impairment in Logopenic Progressive Aphasia. ...
Ramanan, Siddharth; Foxe, David; El-Omar, Hashim. - : Apollo - University of Cambridge Repository, 2021
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3
Evidence for a pervasive autobiographical memory impairment in Logopenic Progressive Aphasia.
Ramanan, Siddharth; Foxe, David; El-Omar, Hashim. - : Elsevier BV, 2021. : Neurobiol Aging, 2021
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4
Establishing two principal dimensions of cognitive variation in Logopenic Progressive Aphasia ...
Ramanan, Siddharth; Roquet, Daniel; Goldberg, Zoë-Lee. - : Apollo - University of Cambridge Repository, 2020
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5
Establishing two principal dimensions of cognitive variation in Logopenic Progressive Aphasia
Ramanan, Siddharth; Roquet, Daniel; Goldberg, Zoë-lee. - : Oxford University Press, 2020. : Brain Communications, 2020
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6
Dementia diagnosis in seven languages: the Addenbrooke’s Cognitive Examination-III in India
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7
Establishing two principal dimensions of cognitive variation in logopenic progressive aphasia
In: Brain Commun (2020)
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8
Correlates of Anomia in non-semantic Variants of Primary Progressive Aphasia Converge over Time ...
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9
Correlates of Anomia in non-semantic Variants of Primary Progressive Aphasia Converge over Time ...
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10
Prevalence of Amyloid-β Pathology in Distinct Variants of Primary Progressive Aphasia
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11
Prevalence of amyloid-β pathology in distinct variants of primary progressive aphasia: Amyloid-β Pathology in PPA
In: Annals of Neurology. - 84, 5 (2018) , 729-740, ISSN: 0364-5134 (2018)
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12
External details revisited – A new taxonomy for coding ‘non-episodic’ content during autobiographical memory retrieval
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13
Cerebellar Atrophy and Its Contribution to Cognition in Frontotemporal Dementias
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14
Common and divergent neural correlates of anomia in amnestic and logopenic presentations of Alzheimer's disease
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15
Neural Substrates of Semantic Prospection – Evidence from the Dementias
Abstract: The ability to envisage personally relevant events at a future time point represents an incredibly sophisticated cognitive endeavor and one that appears to be intimately linked to episodic memory integrity. Far less is known regarding the neurocognitive mechanisms underpinning the capacity to envisage non-personal future occurrences, known as semantic future thinking. Moreover the degree of overlap between the neural substrates supporting episodic and semantic forms of prospection remains unclear. To this end, we sought to investigate the capacity for episodic and semantic future thinking in Alzheimer’s disease (n = 15) and disease-matched behavioral-variant frontotemporal dementia (n = 15), neurodegenerative disorders characterized by significant medial temporal lobe (MTL) and frontal pathology. Participants completed an assessment of past and future thinking across personal (episodic) and non-personal (semantic) domains, as part of a larger neuropsychological battery investigating episodic and semantic processing, and their performance was contrasted with 20 age- and education-matched healthy older Controls. Participants underwent whole-brain T1-weighted structural imaging and voxel-based morphometry analysis was conducted to determine the relationship between gray matter integrity and episodic and semantic future thinking. Relative to Controls, both patient groups displayed marked future thinking impairments, extending across episodic and semantic domains. Analyses of covariance revealed that while episodic future thinking deficits could be explained solely in terms of episodic memory proficiency, semantic prospection deficits reflected the interplay between episodic and semantic processing. Distinct neural correlates emerged for each form of future simulation with differential involvement of prefrontal, lateral temporal, and medial temporal regions. Notably, the hippocampus was implicated irrespective of future thinking domain, with the suggestion of lateralization effects depending on the type of information being simulated. Whereas episodic future thinking related to right hippocampal integrity, semantic future thinking was found to relate to left hippocampal integrity. Our findings support previous observations of significant MTL involvement for semantic forms of prospection and point to distinct neurocognitive mechanisms which must be functional to support future-oriented forms of thought across personal and non-personal contexts.
Keyword: Neuroscience
URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877391/
https://doi.org/10.3389/fnbeh.2016.00096
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16
An Update on semantic dementia : genetics, imaging, and pathology
Landin-Romero, Ramon; Tan, Rachel; Hodges, John R. - : BioMed Central, 2016
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17
'Language of the past' - exploring past tense disruption during autobiographical narration in neurodegenerative disorders
Irish, Muireann; Kamminga, Jody; Addis, Donna Rose. - : John Wiley & Sons, 2016
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18
The longitudinal interplay of behavorial symptoms and functional decline in frontotemporal dementia
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19
Syntactic comprehension deficits across the FTD-ALS continuum
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20
Non-verbal episodic memory deficits in primary progressive aphasias are highly predictive of underlying amyloid pathology
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