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Examining the presence and nature of delusions in Alzheimer's disease and frontotemporal dementia syndromes
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Evidence for a pervasive autobiographical memory impairment in Logopenic Progressive Aphasia. ...
Ramanan, Siddharth; Foxe, David; El-Omar, Hashim. - : Apollo - University of Cambridge Repository, 2021
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3
Evidence for a pervasive autobiographical memory impairment in Logopenic Progressive Aphasia.
Ramanan, Siddharth; Foxe, David; El-Omar, Hashim. - : Elsevier BV, 2021. : Neurobiol Aging, 2021
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4
Establishing two principal dimensions of cognitive variation in Logopenic Progressive Aphasia ...
Ramanan, Siddharth; Roquet, Daniel; Goldberg, Zoë-Lee. - : Apollo - University of Cambridge Repository, 2020
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5
Establishing two principal dimensions of cognitive variation in Logopenic Progressive Aphasia
Ramanan, Siddharth; Roquet, Daniel; Goldberg, Zoë-lee. - : Oxford University Press, 2020. : Brain Communications, 2020
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6
Dementia diagnosis in seven languages: the Addenbrooke’s Cognitive Examination-III in India
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7
Establishing two principal dimensions of cognitive variation in logopenic progressive aphasia
In: Brain Commun (2020)
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8
Correlates of Anomia in non-semantic Variants of Primary Progressive Aphasia Converge over Time ...
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9
Correlates of Anomia in non-semantic Variants of Primary Progressive Aphasia Converge over Time ...
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10
Prevalence of Amyloid-β Pathology in Distinct Variants of Primary Progressive Aphasia
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11
Prevalence of amyloid-β pathology in distinct variants of primary progressive aphasia: Amyloid-β Pathology in PPA
In: Annals of Neurology. - 84, 5 (2018) , 729-740, ISSN: 0364-5134 (2018)
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12
External details revisited – A new taxonomy for coding ‘non-episodic’ content during autobiographical memory retrieval
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13
Cerebellar Atrophy and Its Contribution to Cognition in Frontotemporal Dementias
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14
Common and divergent neural correlates of anomia in amnestic and logopenic presentations of Alzheimer's disease
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15
Neural Substrates of Semantic Prospection – Evidence from the Dementias
Irish, Muireann; Eyre, Nadine; Dermody, Nadene. - : Frontiers Media S.A., 2016
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16
An Update on semantic dementia : genetics, imaging, and pathology
Landin-Romero, Ramon; Tan, Rachel; Hodges, John R. - : BioMed Central, 2016
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17
'Language of the past' - exploring past tense disruption during autobiographical narration in neurodegenerative disorders
Irish, Muireann; Kamminga, Jody; Addis, Donna Rose. - : John Wiley & Sons, 2016
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18
The longitudinal interplay of behavorial symptoms and functional decline in frontotemporal dementia
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19
Syntactic comprehension deficits across the FTD-ALS continuum
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20
Non-verbal episodic memory deficits in primary progressive aphasias are highly predictive of underlying amyloid pathology
Abstract: Diagnostic distinction of primary progressive aphasias (PPA) remains challenging, in particular for the logopenic (lvPPA) and nonfluent/agrammatic (naPPA) variants. Recent findings highlight that episodic memory deficits appear to discriminate these PPA variants from each other, as only lvPPA perform poorly on these tasks while having underlying amyloid pathology similar to that seen in amnestic dementias like Alzheimer’s disease (AD). Most memory tests are, however, language based and thus potentially confounded by the prevalent language deficits in PPA. The current study investigated this issue across PPA variants by contrasting verbal and non-verbal episodic memory measures while controlling for their performance on a language subtest of a general cognitive screen. A total of 203 participants were included (25 lvPPA; 29 naPPA; 59 AD; 90 controls) and underwent extensive verbal and non-verbal episodic memory testing, with a subset of patients (n = 45) with confirmed amyloid profiles as assessed by Pittsburgh Compound B and PET. The most powerful discriminator between naPPA and lvPPA patients was a non-verbal recall measure (Rey Complex Figure delayed recall), with 81% of PPA patients classified correctly at presentation. Importantly, AD and lvPPA patients performed comparably on this measure, further highlighting the importance of underlying amyloid pathology in episodic memory profiles. The findings demonstrate that non-verbal recall emerges as the best discriminator of lvPPA and naPPA when controlling for language deficits in high load amyloid PPA cases.
URL: https://ueaeprints.uea.ac.uk/id/eprint/58610/
https://ueaeprints.uea.ac.uk/id/eprint/58610/1/Hornberger_M_Non_verbal_episodic_memory_accepted_manuscript.pdf
https://doi.org/10.3233/JAD-150752
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