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A specific cognitive deficit within semantic cognition across a multi-generational family.
In: Proc Biol Sci , 279 (1743) 3652 - 3661. (2012) (2012)
Abstract: We report a study of eight members of a single family (aged 8-72 years), who all show a specific deficit in linking semantic knowledge to language. All affected members of the family had high levels of overall intelligence; however, they had profound difficulties in prose and sentence recall, listening comprehension and naming. The behavioural deficit was remarkably consistent across affected family members. Structural neuroimaging data revealed grey matter abnormalities in the left infero-temporal cortex and fusiform gyri: brain areas that have been associated with integrative semantics. This family demonstrates, to our knowledge, the first example of a heritable, highly specific abnormality affecting the interface between language and cognition in humans and has important implications for our understanding of the genetic basis of cognition.
Keyword: Adolescent; Adult; Aged; Anomia; Case-Control Studies; Child; Cognition Disorders; England; Female; Humans; Language; Magnetic Resonance Imaging; Male; Mental Recall; Middle Aged; Neuroimaging; Preschool; Temporal Lobe
URL: http://discovery.ucl.ac.uk/1358920/
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2
Exploration of a 'double-jeopardy' hypothesis within working memory profiles for children with specific language impairment.
In: Int J Lang Commun Disord , 44 (2) pp. 236-250. (2009) (2009)
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3
Exploration of a 'double-jeopardy' hypothesis within working memory profiles for children with specific language impairment
In: International Journal of Language and Communication Disorders , 44 (2) pp. 236-250. (2009) (2009)
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4
The beauty of models for developmental disorders
In: Behavioral and brain sciences. - New York, NY [u.a.] : Cambridge Univ. Press 25 (2002) 6, 750-751
OLC Linguistik
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5
Are developmental disorders like cases of adult brain damage? : Implications from connectionist modelling (incl. open peer commentary and authors' response)
In: Behavioral and brain sciences. - New York, NY [u.a.] : Cambridge Univ. Press 25 (2002) 6, 727-787
BLLDB
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6
Does impaired grammatical comprehension provide evidence for an innate grammar module?
In: Applied Psycholinguistics, 23 (2002)
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7
Does impaired grammatical comprehension provide evidence for an innate grammar module?
In: Applied Psycholinguistics, 23 (2002)
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8
Does impaired grammatical comprehension provide evidence for an innate grammar module?
In: Applied Psycholinguistics, 23 (2002)
BASE
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9
Does impaired grammatical comprehension provide evidence for an innate grammar module?
In: Applied Psycholinguistics, 23 (2002)
BASE
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10
Does impaired grammatical comprehension provide evidence for an innate grammar module?
In: Applied Psycholinguistics, 23 (2002)
BASE
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11
Does impaired grammatical comprehension provide evidence for an innate grammar module?
In: Applied Psycholinguistics, 23 (2002)
BASE
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12
Does impaired grammatical comprehension provide evidence for an innate grammar module?
In: Applied Psycholinguistics, 23 (2002)
BASE
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13
Does impaired grammatical comprehension provide evidence for an innate grammar module?
In: Applied Psycholinguistics, 23 (2002)
BASE
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14
Does impaired grammatical comprehension provide evidence for an innate grammar module?
In: Applied Psycholinguistics, 23 (2002)
BASE
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15
Does impaired grammatical comprehension provide evidence for an innate grammar module?
In: Applied Psycholinguistics, 23 (2002)
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16
Does impaired grammatical comprehension provide evidence for an innate grammar module?
In: Symplectic Elements at Oxford ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; Scopus (http://www.scopus.com/home.url) ; CrossRef (2002)
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17
Phonological processing, language and literacy: A comparison of children with mild to moderate sensori-neural hearing loss and those with specific language impairment
In: Journal of Child Psychology and Psychiatry, 42 (2001)
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18
Phonological processing, language, and literacy: a comparison of children with mild-to-moderate sensorineural hearing loss and those with specific language impairment.
In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; CrossRef (2001)
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19
Production of English finite verb morphology: a comparison of SLI and mild-moderate hearing impairment.
In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; Scopus (http://www.scopus.com/home.url) ; CrossRef (2001)
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20
Phonological processing, language, and literacy: a comparison of children with mild-to-moderate sensorineural hearing loss and those with specific language impairment.
In: J Child Psychol Psychiatry , 42 (3) pp. 329-340. (2001) (2001)
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