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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Hits 1 – 12 of 12 1 White Matter Disruption and Connected Speech in Non-Fluent and Semantic Variants of Primary Progressive Aphasia Marcotte, Karine; Graham, Naida L.; Fraser, Kathleen C.; Meltzer, Jed A.; Tang-Wai, David F.; Chow, Tiffany W.; Freedman, Morris; Leonard, Carol; Black, Sandra E.; Rochon, Elizabeth. - : S. Karger AG, 2017 Abstract: Differential patterns of white matter disruption have recently been reported in the non-fluent (nfvPPA) and semantic (svPPA) variants of primary progressive aphasia (PPA). No single measure is sufficient to distinguish between the PPA variants, but connected speech allows for the quantification of multiple measures. The aim of the present study was to further investigate the white matter correlates associated with connected speech features in PPA. We examined the relationship between white matter metrics and connected speech deficits using an automated analysis of transcriptions of connected speech and diffusion tensor imaging in language-related tracts. Syntactic, lexical, and semantic features were automatically extracted from transcriptions of topic-directed interviews conducted with groups of individuals with nfvPPA or svPPA as well as with a group of healthy controls. A principal component analysis was performed in order to reduce the number of language measures and yielded a five-factor solution. The results indicated that nfvPPA patients differed from healthy controls on a syntactic factor, and svPPA patients differed from controls on two semantic factors. However, the patient groups did not differ on any factor. Moreover, a correlational analysis revealed that the lexical richness factor was significantly correlated with radial diffusivity in the left inferior longitudinal fasciculus, which suggests that semantic deficits in connected speech reflect a disruption of this ventral pathway, and which is largely consistent with the results of previous studies. Using an automated approach for the analysis of connected speech combined with probabilistic tractography, the present findings demonstrate that nfvPPA patients are impaired relative to healthy controls on syntactic measures and have increased radial diffusivity in the left superior longitudinal fasciculus, whereas the svPPA group was impaired on lexico-semantic measures relative to controls and showed increased radial diffusivity in the uncinate and inferior longitudinal fasciculus bilaterally. Keyword: Original Research Article URL: https://doi.org/10.1159/000456710 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5465709/ BASE Hide details 2 White Matter Disruption and Connected Speech in Non-Fluent and Semantic Variants of Primary Progressive Aphasia Marcotte, Karine; Graham, Naida L; Fraser, Kathleen C. - : Karger Publishers, 2017 BASE Show details 3 Lack of Frank Agrammatism in the Nonfluent Agrammatic Variant of Primary Progressive Aphasia Graham, Naida L.; Leonard, Carol; Tang-Wai, David F.. - : S. Karger AG, 2016 BASE Show details 4 Lack of Frank Agrammatism in the Nonfluent Agrammatic Variant of Primary Progressive Aphasia Graham, Naida L; Leonard, Carol; Tang-Wai, David F. - 2016 BASE Show details 5 Profiling Speech and Pausing in Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) Yunusova, Yana; Graham, Naida L.; Shellikeri, Sanjana. - : Public Library of Science, 2016 BASE Show details 6 Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia Rascovsky, Katya; Hodges, John R.; Knopman, David. - : Oxford University Press, 2011 BASE Show details 7 Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia Rascovsky, Katya; Hodges, John R.; Knopman, David. - : Oxford University Press, 2011 BASE Show details 8 Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia Rascovsky, Katya; Hodges, John R.; Knopman, David. - : Oxford University Press, 2011 BASE Show details 9 Alzheimer Disease Neuropathologic Changes in Semantic Dementia Chow, Tiffany; Varpetian, Arousiak; Moss, Taryn. - 2009 BASE Show details 10 A neurocomputational model of analogical reasoning and its breakdown in frontotemporal lobar degeneration Morrison, Robert G.; Krawczyk, Daniel C.; Holyoak, Keith J.... In: Journal of cognitive neuroscience. - Cambridge, Mass. : MIT Press Journals 16 (2004) 2, 260-271 BLLDB Show details 11 A Neurocomputational Model of Analogical Reasoning and its Breakdown in Frontotemporal Lobar Degeneration Morrison, Robert G.; Krawczyk, Daniel C.; Holyoak, Keith J.... In: Journal of cognitive neuroscience. - Cambridge, Mass. : MIT Press Journals 16 (2004) 2, 260-271 OLC Linguistik Show details 12 A Neurocomputational Model of Analogical Reasoning and its Breakdown in Frontotemporal Lobar Degeneration Morrison, Robert G; Krawczyk, Daniel C.; Holyoak, Keith J.... In: Psychology: Faculty Publications and Other Works (2004) BASE Show details

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