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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Page: 1 2 3 Hits 1 – 20 of 42 1 Tractography of supplementary motor area projections in progressive speech apraxia and aphasia Valls Carbo, Adrian; Reid, Robert I.; Tosakulwong, Nirubol... In: Neuroimage Clin (2022) BASE Show details 2 Posterior cortical atrophy phenotypic heterogeneity revealed by decoding (18)F-FDG-PET Townley, Ryan A; Botha, Hugo; Graff-Radford, Jonathan... In: Brain Commun (2021) BASE Show details 3 Changing the face of neuroimaging research: Comparing a new MRI de-facing technique with popular alternatives Schwarz, Christopher G.; Kremers, Walter K.; Wiste, Heather J.... In: Neuroimage (2021) BASE Show details 4 A molecular pathology, neurobiology, biochemical, genetic and neuroimaging study of progressive apraxia of speech Josephs, Keith A.; Duffy, Joseph R.; Clark, Heather M.... In: Nat Commun (2021) BASE Show details 5 Longitudinal neuroimaging biomarkers differ across Alzheimer’s disease phenotypes Sintini, Irene; Graff-Radford, Jonathan; Senjem, Matthew L... In: Brain (2020) BASE Show details 6 Association of amyloid angiopathy with microbleeds in logopenic progressive aphasia: an imaging-pathology study Buciuc, Marina; Duffy, Joseph R.; Machulda, Mary M.... In: Eur J Neurol (2020) BASE Show details 7 Longitudinal anatomic, functional, and molecular characterization of Pick disease phenotypes Whitwell, Jennifer L.; Tosakulwong, Nirubol; Schwarz, Christopher C.; Senjem, Matthew L.; Spychalla, Anthony J.; Duffy, Joseph R.; Graff-Radford, Jon; Machulda, Mary M.; Boeve, Bradley F.; Knopman, David S.; Petersen, Ronald C.; Lowe, Val J.; Jack, Clifford R.; Dickson, Dennis W.; Parisi, Joseph E.; Josephs, Keith A. In: Neurology (2020) Abstract: OBJECTIVE: To characterize longitudinal MRI and PET abnormalities in autopsy-confirmed Pick disease (PiD) and determine how patterns of neurodegeneration differ with respect to clinical syndrome. METHODS: Seventeen patients with PiD were identified who had antemortem MRI (8 with behavioral variant frontotemporal dementia [bvFTD-PiD], 6 with nonfluent/agrammatic primary progressive aphasia [naPPA-PiD], 1 with semantic primary progressive aphasia, 1 with unclassified primary progressive aphasia, and 1 with corticobasal syndrome). Thirteen patients had serial MRI for a total of 56 MRIs, 7 had [(18)F]fluorodeoxyglucose PET, 4 had Pittsburgh compound B (PiB) PET, and 1 patient had [(18)F]flortaucipir PET. Cross-sectional and longitudinal comparisons of gray matter volume and metabolism were performed between bvFTD-PiD, naPPA-PiD, and controls. Cortical PiB summaries were calculated to determine β-amyloid positivity. RESULTS: The bvFTD-PiD and naPPA-PiD groups showed different foci of volume loss and hypometabolism early in the disease, with bvFTD-PiD involving bilateral prefrontal and anterior temporal cortices and naPPA-PiD involving left inferior frontal gyrus, insula, and orbitofrontal cortex. However, patterns merged over time, with progressive spread into prefrontal and anterior temporal lobe in naPPA-PiD, and eventual involvement of posterior temporal lobe, motor cortex, and parietal lobe in both groups. Rates of frontotemporal atrophy were faster in bvFTD-PiD than naPPA-PiD. One patient was β-amyloid–positive on PET with low Alzheimer neuropathologic changes at autopsy. Flortaucipir PET showed elevated uptake in frontotemporal white matter. CONCLUSION: Patterns of atrophy and hypometabolism differ in PiD according to presenting syndrome, although patterns of neurodegeneration appear to converge over time. Keyword: Article URL: https://doi.org/10.1212/WNL.0000000000010948 http://www.ncbi.nlm.nih.gov/pubmed/32989107 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836669/ BASE Hide details 8 An Evaluation of the Progressive Supranuclear Palsy Speech/Language Variant Whitwell, Jennifer L.; Stevens, Chase A.; Duffy, Joseph R.... In: Mov Disord Clin Pract (2019) BASE Show details 9 Clinical and Neuroimaging Characteristics of Clinically Unclassifiable Primary Progressive Aphasia Utianski, Rene L.; Botha, Hugo; Martin, Peter R.... In: Brain Lang (2019) BASE Show details 10 The influence of β-amyloid on [(18)F]AV-1451 in semantic variant of primary progressive aphasia Whitwell, Jennifer L.; Martin, Peter R.; Duffy, Joseph R.. - : Lippincott Williams & Wilkins, 2019 BASE Show details 11 Patterns of Neuropsychological Dysfunction and Cortical Volume Changes in Logopenic Aphasia Owens, Tyler E.; Machulda, Mary M.; Duffy, Joseph R.. - 2018 BASE Show details 12 [18F]AV-1451 tau-PET and primary progressive aphasia Josephs, Keith A.; Martin, Peter R.; Botha, Hugo. - 2018 BASE Show details 13 Tau Uptake in Agrammatic Primary Progressive Aphasia with and without Apraxia of Speech Utianski, Rene L.; Whitwell, Jennifer L.; Schwarz, Christopher G.. - 2018 BASE Show details 14 Disrupted functional connectivity in primary progressive apraxia of speech Botha, Hugo; Utianski, Rene L.; Whitwell, Jennifer L.. - : Elsevier, 2018 BASE Show details 15 Tau-PET imaging with [18F]AV-1451 in Primary Progressive Apraxia of Speech Utianski, Rene L.; Whitwell, Jennifer L.; Schwarz, Christopher G.. - 2018 BASE Show details 16 Prosodic and Phonetic Subtypes of Primary Progressive Apraxia of Speech Utianski, Rene L.; Duffy, Joseph R.; Clark, Heather M.. - 2018 BASE Show details 17 Predicting clinical decline in progressive agrammatic aphasia and apraxia of speech Whitwell, Jennifer L.; Weigand, Stephen D.; Duffy, Joseph R.. - : Lippincott Williams & Wilkins, 2017 BASE Show details 18 Varying degrees of temporoparietal hypometabolism on FDG-PET reveal amyloid-positive logopenic primary progressive aphasia is not a homogeneous clinical entity Krishnan, Kamini; Machulda, Mary M.; Whitwell, Jennifer L.. - 2017 BASE Show details 19 Association Between Anticholinergic Medication Use and Cognition, Brain Metabolism, and Brain Atrophy in Cognitively Normal Older Adults Risacher, Shannon Leigh; McDonald, Brenna C.; Tallman, Eileen F.... In: PMC (2016) BASE Show details 20 Tracking the Development of Agrammatic Aphasia: a Tensor-Based Morphometry Study Whitwell, Jennifer L.; Duffy, Joseph R.; Machulda, Mary M.. - 2016 BASE Show details Page: 1 2 3

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