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1
Understanding quantity in semantic dementia
In: Cognitive neuropsychology. - Abingdon : Routledge, Taylor & Francis Group 27 (2010) 1-2, 3-29
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2
Frequency and clinical characteristics of progranulin mutation carriers in the Manchester frontotemporal lobar degeneration cohort: comparison with patients with MAPT and no known mutations
Pickering-Brown, Stuart M.; Rollinson, Sara; Du Plessis, Daniel. - : Oxford University Press, 2008
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3
Frequency and clinical characteristics of progranulin mutation carriers in the Manchester frontotemporal lobar degeneration cohort: comparison with patients with MAPT and no known mutations
Pickering-Brown, Stuart M.; Rollinson, Sara; Plessis, Daniel Du. - : Oxford University Press, 2008
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4
Cognitive phenotypes in Alzheimer's Disease and genetic risk
Abstract: Variation in the clinical characteristics of patients with Alzheimer's disease (AD) is increasingly recognised, although the factors underlying variation are not fully understood. The study examined the cognitive characteristics of 523 AD patients at the time of their presentation to a neurological dementia clinic and explored the relationship to family history and apolipoprotein E (APOE) genotype. Distinct profiles were identified, which were mirrored by topographical differences on neuroimaging. Clinical distinctions were maintained over time. Two-thirds of patients showed a constellation of deficits at presentation which included memory, language, visuospatial and constructional difficulties. However, a quarter had circumscribed presentations of amnesia, aphasia, perceptuospatial disorder or apraxia. The rare presence of frontal lobe characteristics was associated with a younger age of onset, an increased incidence of myoclonus at presentation, a positive family history but not with possession of APOE ɛ4 allele. An amnestic presentation (severe, yet circumscribed amnesia) was strongly associated with an older age of onset, a positive family history and the presence of APOE ɛ4 allele. Posterior cortical presentations showed a female bias, were typically sporadic, and showed no association with APOE ɛ4. The findings support the notion of phenotypic variation in AD, and show that genetic risk factors can influence clinical presentation. The findings draw attention to the specific association between APOE ɛ4 allele and memory but challenge the commonly held notion that the presence of the ɛ4 allele inevitably reduces onset age. The findings indicate that risk factors other than APOE ɛ4 allele underlie the non-familial, early onset posterior hemisphere presentations of AD.
Keyword: 1109 Neurosciences; Alzheimer's disease; APOE [.epsilon]4; APOE ɛ4; Cognitive impairment; Genetic risk
URL: https://espace.library.uq.edu.au/view/UQ:192278
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5
Knowledge of famous faces and names in semantic dementia
In: Brain. - Oxford : Oxford Univ. Press 127 (2004) 4, 860-872
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6
The impact of autobiographical experience on meaning : reply to Graham, Lambon Ralph, and Hodges
In: Cognitive neuropsychology. - Abingdon : Routledge, Taylor & Francis Group 16 (1999) 7, 673-687
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7
Fronto-temporal lobar generation : fronto-temporal dementia, progressive aphasia, semantic dementia
Snowden, Julie S.; Neary, David; Mann, David M.A.. - New York : Livingstone, 1996
MPI für Psycholinguistik
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8
Semantic-episodic memory interactions in semantic dementia : implications for retrograde memory function
In: Cognitive neuropsychology. - Abingdon : Routledge, Taylor & Francis Group 13 (1996) 8, 1101-1137
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9
Semantic-Episodic Memory Interactions in Semantic Dementia: Implications for Retrograde Memory Function
In: Cognitive neuropsychology. - Abingdon : Routledge, Taylor & Francis Group 13 (1996) 8, 1101-1138
OLC Linguistik
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10
The dementias
Stuss, Donald T. (Hrsg.); Levine, Brian (Mitarb.); Milberg, William (Mitarb.)...
In: Brain and cognition. - San Diego, Calif. [u.a.] : Elsevier Science 31 (1996) 2, 97- 282
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11
Fronto-temporal Dementia: Nosology, Neuropsychology, and Neuropathology
In: Brain and cognition. - San Diego, Calif. [u.a.] : Elsevier Science 31 (1996) 2, 176-187
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12
Autobiographical experience and word meaning
In: Semantic knowledge and semantic representations (Hove, 1995), p. 225-246
MPI für Psycholinguistik
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13
Semantic dementia : autobiographical contribution to preservation of meaning
In: Cognitive neuropsychology. - Abingdon : Routledge, Taylor & Francis Group 11 (1994) 3, 265-288
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