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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Hits 1 – 9 of 9 1 Facilitators and Barriers to Dementia Assessment and Diagnosis: Perspectives From Dementia Experts Within a Global Health Context Bernstein Sideman, Alissa; Al-Rousan, Tala; Tsoy, Elena... In: Front Neurol (2022) BASE Show details 2 Depressive Symptom Profiles Predict Specific Neurodegenerative Disease Syndromes in Early Stages. Shdo, Suzanne M; Ranasinghe, Kamalini G; Sturm, Virginia E. - : eScholarship, University of California, 2020 BASE Show details 3 Depressive Symptom Profiles Predict Specific Neurodegenerative Disease Syndromes in Early Stages. Shdo, Suzanne M; Ranasinghe, Kamalini G; Sturm, Virginia E; Possin, Katherine L; Bettcher, Brianne M; Stephens, Melanie L; Foley, Jessica M; You, Shou-Chin Christine; Rosen, Howard J; Miller, Bruce L; Kramer, Joel H; Rankin, Katherine P. - : eScholarship, University of California, 2020 Abstract: Background: During early stages, patients with neurodegenerative diseases (NDG) often present with depressive symptoms. However, because depression is a heterogeneous disorder, more precise delineation of the specific depressive symptom profiles that arise early in distinct NDG syndromes is necessary to enhance patient diagnosis and care. Methods and Findings: Five-hundred and sixty four participants self-reported their depressive symptoms using the Geriatric Depression Scale (GDS), including 111 healthy older control subjects (NC) and 453 patients diagnosed with one of six NDGs who were at the mild stage of disease (CDR® Dementia Staging Instrument ≤ 1) [186 Alzheimer's disease (AD), 76 behavioral variant frontotemporal dementia (bvFTD), 52 semantic variant primary progressive aphasia (svPPA), 46 non-fluent variant PPA (nfvPPA), 49 progressive supranuclear palsy syndrome (PSPS), 44 corticobasal syndrome (CBS)]. The GDS was divided into subscales based on a previously published factor analysis, representing five symptoms (dysphoria, hopelessness, withdrawal, worry, and cognitive concerns). Mixed models were created to examine differences in depression subscale by group, and logistic regression analyses were performed to determine if patterns of depressive symptoms could predict a patient's NDG syndrome. PSPS patients presented with a hopeless, dysphoric, and withdrawn pattern, while patients with CBS presented with a similar but less severe pattern. Worry was a key symptom in the profile of patients with svPPA, while ADs only had abnormally elevated cognitive concerns. Depressive profile accurately predicted NDG diagnosis at a rate of between 70 and 84% accuracy. Conclusions: These results suggest that attention to specific depressive symptom profile can improve diagnostic sensitivity and can be used to provide more individualized patient care. Keyword: 2.1 Biological and endogenous factors; 7.3 Management and decision making; Acquired Cognitive Impairment; Aging; Alzheimer's; Alzheimer's Disease; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Behavioral and Social Science; Brain Disorders; Clinical Research; Clinical Sciences; Dementia; depression; dysphora; frontotemporal dementia; Frontotemporal Dementia (FTD); hopelessness; Mental Health; Neurodegenerative; neurodegenerative disease; Neurological; Neurosciences; progressive supranuclear palsy; Psychology; Rare Diseases; worry URL: https://escholarship.org/uc/item/7d043256 BASE Hide details 4 Depressive Symptom Profiles Predict Specific Neurodegenerative Disease Syndromes in Early Stages Shdo, Suzanne M.; Ranasinghe, Kamalini G.; Sturm, Virginia E.... In: Front Neurol (2020) BASE Show details 5 Visuospatial Functioning In The Primary Progressive Aphasias Watson, Christa L.; Possin, Katherine; Allen, I. Elaine. - : Cambridge Univ Press, 2018 BASE Show details 6 Visuospatial Functioning in the Primary Progressive Aphasias Watson, Christa L.; Possin, Katherine; Allen, I. Elaine. - 2017 BASE Show details 7 Assessment of cognition in early dementia Silverberg, Nina B.; Ryan, Laurie M.; Carrillo, Maria C.. - 2011 BASE Show details 8 Atrophy in two attention networks is associated with performance on a Flanker task in neurodegenerative disease Luks, Tracy L.; Oliveira, Michael; Possin, Katherine L.. - 2010 BASE Show details 9 Lack of Impairment in Patients With Parkinson's Disease on an Object-based Negative Priming Task Possin, Katherine L.; Cagigas, Xavier E.; Strayer, David L.... In: Perceptual & motor skills. - Thousand Oaks, CA : SAGE Publications 102 (2006) 1, 219-230 OLC Linguistik Show details

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