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1
Investigating the effect of changing parameters when building prediction models in post-stroke aphasia
In: Nat Hum Behav (2020)
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Auditory, Phonological, and Semantic Factors in the Recovery From Wernicke’s Aphasia Poststroke: Predictive Value and Implications for Rehabilitation ...
Robson, Holly; Griffiths, Timothy D.; Grube, Manon. - : SAGE Journals, 2019
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Auditory, Phonological, and Semantic Factors in the Recovery From Wernicke’s Aphasia Poststroke: Predictive Value and Implications for Rehabilitation ...
Robson, Holly; Griffiths, Timothy D.; Grube, Manon. - : SAGE Journals, 2019
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4
SD-squared revisited: reply to Coltheart, Tree, and Saunders (2010). ...
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5
Predicting the pattern and severity of chronic post-stroke language deficits from functionally-partitioned structural lesions
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6
Triangulation of language-cognitive impairments, naming errors and their neural bases post-stroke
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7
Seeing the Meaning: Top–Down Effects on Letter Identification
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8
Laterality of anterior temporal lobe repetitive transcranial magnetic stimulation determines the degree of disruption in picture naming
Woollams, Anna M.; J. Lindley, Lee; Pobric, Gorana. - : Springer Berlin Heidelberg, 2017
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9
Reduced neural ‘effort’ after naming treatment in anomia
Thompson, Hannah; Woollams, Anna M. - : Oxford University Press (OUP), 2017
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10
Do You Read How I Read? Systematic Individual Differences in Semantic Reliance amongst Normal Readers
Woollams, Anna M.; Lambon Ralph, Matthew A.; Madrid, Gaston. - : Frontiers Media S.A., 2016
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11
Taking Sides: An Integrative Review of the Impact of Laterality and Polarity on Efficacy of Therapeutic Transcranial Direct Current Stimulation for Anomia in Chronic Poststroke Aphasia
Sandars, Margaret; Cloutman, Lauren; Woollams, Anna M.. - : Hindawi Publishing Corporation, 2016
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12
Lexical is as lexical does: computational approaches to lexical representation
Woollams, Anna M.. - : Routledge, 2015
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13
Opposing Effects of Semantic Diversity in Lexical and Semantic Relatedness Decisions
Hoffman, Paul; Woollams, Anna M.. - : American Psychological Association, 2015
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14
Processing deficits for familiar and novel faces in patients with left posterior fusiform lesions
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15
Triangulation of the neurocomputational architecture underpinning reading aloud
Hoffman, Paul; Lambon Ralph, Matthew A.; Woollams, Anna M.. - : National Academy of Sciences, 2015
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16
Semantic memory: which side are you on?
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17
What lies beneath: A comparison of reading aloud in pure alexia and semantic dementia
In: Cognitive neuropsychology. - Abingdon : Routledge, Taylor & Francis Group 31 (2014) 5, 461-481
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18
Capturing multidimensionality in stroke aphasia: mapping principal behavioural components to neural structures
Butler, Rebecca A.; Lambon Ralph, Matthew A.; Woollams, Anna M.. - : Oxford University Press, 2014
Abstract: Stroke aphasia is a multidimensional disorder in which patient profiles reflect variation along multiple behavioural continua. We present a novel approach to separating the principal aspects of chronic aphasic performance and isolating their neural bases. Principal components analysis was used to extract core factors underlying performance of 31 participants with chronic stroke aphasia on a large, detailed battery of behavioural assessments. The rotated principle components analysis revealed three key factors, which we labelled as phonology, semantic and executive/cognition on the basis of the common elements in the tests that loaded most strongly on each component. The phonology factor explained the most variance, followed by the semantic factor and then the executive-cognition factor. The use of principle components analysis rendered participants’ scores on these three factors orthogonal and therefore ideal for use as simultaneous continuous predictors in a voxel-based correlational methodology analysis of high resolution structural scans. Phonological processing ability was uniquely related to left posterior perisylvian regions including Heschl’s gyrus, posterior middle and superior temporal gyri and superior temporal sulcus, as well as the white matter underlying the posterior superior temporal gyrus. The semantic factor was uniquely related to left anterior middle temporal gyrus and the underlying temporal stem. The executive-cognition factor was not correlated selectively with the structural integrity of any particular region, as might be expected in light of the widely-distributed and multi-functional nature of the regions that support executive functions. The identified phonological and semantic areas align well with those highlighted by other methodologies such as functional neuroimaging and neurostimulation. The use of principle components analysis allowed us to characterize the neural bases of participants’ behavioural performance more robustly and selectively than the use of raw assessment scores or diagnostic classifications because principle components analysis extracts statistically unique, orthogonal behavioural components of interest. As such, in addition to improving our understanding of lesion–symptom mapping in stroke aphasia, the same approach could be used to clarify brain–behaviour relationships in other neurological disorders.
Keyword: Original Articles
URL: https://doi.org/10.1093/brain/awu286
http://brain.oxfordjournals.org/cgi/content/short/137/12/3248
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19
Capturing multidimensionality in stroke aphasia: mapping principal behavioural components to neural structures
Butler, Rebecca A.; Lambon Ralph, Matthew A.; Woollams, Anna M.. - : Oxford University Press, 2014
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20
Connectionist neuropsychology: uncovering ultimate causes of acquired dyslexia
Woollams, Anna M.. - : The Royal Society, 2014
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