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Investigating the effect of changing parameters when building prediction models in post-stroke aphasia
In: Nat Hum Behav (2020)
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Auditory, Phonological, and Semantic Factors in the Recovery From Wernicke’s Aphasia Poststroke: Predictive Value and Implications for Rehabilitation ...
Robson, Holly; Griffiths, Timothy D.; Grube, Manon. - : SAGE Journals, 2019
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Auditory, Phonological, and Semantic Factors in the Recovery From Wernicke’s Aphasia Poststroke: Predictive Value and Implications for Rehabilitation ...
Robson, Holly; Griffiths, Timothy D.; Grube, Manon. - : SAGE Journals, 2019
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4
SD-squared revisited: reply to Coltheart, Tree, and Saunders (2010). ...
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Predicting the pattern and severity of chronic post-stroke language deficits from functionally-partitioned structural lesions
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Triangulation of language-cognitive impairments, naming errors and their neural bases post-stroke
Abstract: In order to gain a better understanding of aphasia one must consider the complex combinations of language impairments along with the pattern of paraphasias. Despite the fact that both deficits and paraphasias feature in diagnostic criteria, most research has focused only on the lesion correlates of language deficits, with minimal attention on the pattern of patients' paraphasias. In this study, we used a data-driven approach (principal component analysis - PCA) to fuse patient impairments and their pattern of errors into one unified model of chronic post-stroke aphasia. This model was subsequently mapped onto the patients' lesion profiles to generate the triangulation of language-cognitive impairments, naming errors and their neural correlates. Specifically, we established the pattern of co-occurrence between fifteen error types, which avoids focussing on a subset of errors or the use of experimenter-derived methods to combine across error types. We obtained five principal components underlying the patients' errors: omission errors; semantically-related responses; phonologically-related responses; dysfluent responses; and a combination of circumlocutions with mixed errors. In the second step, we aligned these paraphasia-related principal components with the patients' performance on a detailed language and cognitive assessment battery, utilising an additional PCA. This omnibus PCA revealed seven unique fused impairment-paraphasia factors: output phonology; semantics; phonological working memory; speech quanta; executive-cognitive skill; phonological (input) discrimination; and the production of circumlocution errors. In doing so we were able to resolve the complex relationships between error types and impairments. Some are relatively straightforward: circumlocution errors formed their own independent factor; there was a one-to-one mapping for phonological errors with expressive phonological abilities and for dysfluent errors with speech fluency. In contrast, omission-type errors loaded across both semantic and phonological working memory factors, whilst semantically-related errors had the most complex relationship by loading across four factors (phonological ability, speech quanta, executive-cognitive skills and circumlocution-type errors). Three components had unique lesion correlates: phonological working memory with the primary auditory region; semantics with the anterior temporal region; and fluency with the pre-central gyrus, converging with existing literature. In conclusion, the data-driven approach allowed derivation of the triangulation of deficits, error types and lesion correlates in post-stroke aphasia.
Keyword: Regular Article
URL: https://doi.org/10.1016/j.nicl.2017.10.037
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683039/
http://www.ncbi.nlm.nih.gov/pubmed/29159059
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7
Seeing the Meaning: Top–Down Effects on Letter Identification
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8
Laterality of anterior temporal lobe repetitive transcranial magnetic stimulation determines the degree of disruption in picture naming
Woollams, Anna M.; J. Lindley, Lee; Pobric, Gorana. - : Springer Berlin Heidelberg, 2017
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9
Reduced neural ‘effort’ after naming treatment in anomia
Thompson, Hannah; Woollams, Anna M. - : Oxford University Press (OUP), 2017
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10
Do You Read How I Read? Systematic Individual Differences in Semantic Reliance amongst Normal Readers
Woollams, Anna M.; Lambon Ralph, Matthew A.; Madrid, Gaston. - : Frontiers Media S.A., 2016
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11
Taking Sides: An Integrative Review of the Impact of Laterality and Polarity on Efficacy of Therapeutic Transcranial Direct Current Stimulation for Anomia in Chronic Poststroke Aphasia
Sandars, Margaret; Cloutman, Lauren; Woollams, Anna M.. - : Hindawi Publishing Corporation, 2016
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12
Lexical is as lexical does: computational approaches to lexical representation
Woollams, Anna M.. - : Routledge, 2015
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13
Opposing Effects of Semantic Diversity in Lexical and Semantic Relatedness Decisions
Hoffman, Paul; Woollams, Anna M.. - : American Psychological Association, 2015
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14
Processing deficits for familiar and novel faces in patients with left posterior fusiform lesions
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15
Triangulation of the neurocomputational architecture underpinning reading aloud
Hoffman, Paul; Lambon Ralph, Matthew A.; Woollams, Anna M.. - : National Academy of Sciences, 2015
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16
Semantic memory: which side are you on?
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17
What lies beneath: A comparison of reading aloud in pure alexia and semantic dementia
In: Cognitive neuropsychology. - Abingdon : Routledge, Taylor & Francis Group 31 (2014) 5, 461-481
OLC Linguistik
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18
Capturing multidimensionality in stroke aphasia: mapping principal behavioural components to neural structures
Butler, Rebecca A.; Lambon Ralph, Matthew A.; Woollams, Anna M.. - : Oxford University Press, 2014
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19
Capturing multidimensionality in stroke aphasia: mapping principal behavioural components to neural structures
Butler, Rebecca A.; Lambon Ralph, Matthew A.; Woollams, Anna M.. - : Oxford University Press, 2014
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20
Connectionist neuropsychology: uncovering ultimate causes of acquired dyslexia
Woollams, Anna M.. - : The Royal Society, 2014
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