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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Hits 1 – 17 of 17 1 Effect of Anti-seizure Medications on Functional Anatomy of Language: A Perspective From Language Functional Magnetic Resonance Imaging Xiao, Fenglai; Caciagli, Lorenzo; Wandschneider, Britta; Joshi, Bhavini; Vos, Sjoerd B.; Hill, Andrea; Galovic, Marian; Long, Lili; Sone, Daichi; Trimmel, Karin; Sander, Josemir W.; Zhou, Dong; Thompson, Pamela J.; Baxendale, Sallie; Duncan, John S.; Koepp, Matthias J. In: Front Neurosci (2022) Abstract: BACKGROUND: In epilepsy, cognitive difficulties are common, partly a consequence of anti-seizure medications (ASM), and cognitive side-effects are often considered to be more disabling than seizures and significantly affect quality of life. Functional MRI during verbal fluency tasks demonstrated impaired frontal activation patterns and failed default mode network deactivation in people taking ASM with unfavourable cognitive profiles. The cognitive effect of ASMs given at different dosages in monotherapy, or in different combinations, remains to be determined. METHODS: Here, we compared the effects of different drug loads on verbal fluency functional MRI (fMRI) in people (i) taking dual therapy of ASMs either considered to be associated with moderate (levetiracetam, lamotrigine, lacosamide, carbamazepine/oxcarbazepine, eslicarbazepine, valproic acid; n = 119, 56 females) or severe (topiramate, zonisamide) side-effects; n = 119, 56 females), (ii) taking moderate ASMs in either mono-, dual- or triple-therapy (60 subjects in each group), or (iii) taking different dosages of ASMs with moderate side-effect profiles (n = 180). “Drug load” was defined as a composite value of numbers and dosages of medications, normalised to account for the highest and lowest dose of each specific prescribed medication. RESULTS: In people taking “moderate” ASMs (n = 119), we observed higher verbal-fluency related to left inferior frontal gyrus and right inferior parietal fMRI activations than in people taking “severe” ASMs (n = 119). Irrespective of the specific ASM, people on monotherapy (n = 60), showed greater frontal activations than people taking two (n = 60), or three ASMs (n = 60). People on two ASMs showed less default mode (precuneus) deactivation than those on monotherapy. In people treated with “moderate” ASMs (n = 180), increased drug load correlated with reduced activation of language-related regions and the right piriform cortex. CONCLUSION: Our study delineates the effects of polytherapy and high doses of ASMs when given in monotherapy on the functional anatomy of language. Irrespective of the cognitive profile of individual ASMs, each additional ASM results in additional alterations of cognitive activation patterns. Selection of ASMs with moderate cognitive side effects, and low doses of ASMs when given in polytherapy, could reduce the cognitive effect. Keyword: Neuroscience URL: https://doi.org/10.3389/fnins.2021.787272 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908426/ BASE Hide details 2 Manifold Learning-based Word Representation Refinement Incorporating Global and Local Information ... The 28th International Conference on Computational Linguistics 2020; Chen, Jinjun; Li , Lin. - : Underline Science Inc., 2020 BASE Show details 3 The focal alteration and causal connectivity in children with new-onset benign epilepsy with centrotemporal spikes Chen, Sihan; Fang, Jiajia; An, Dongmei. - : Nature Publishing Group UK, 2018 BASE Show details 4 Multilingual User Modeling for Personalized Re-ranking of Multilingual Web Search Results GHORAB, MOHAMMED RAMI; ZHOU, DONG; LAWLESS, SEAMUS. - 2012 BASE Show details 5 Multilingual adaptive search for digital libraries Ghorab, M. Rami; Leveling, Johannes; Lawless, Séamus... In: Ghorab, M. Rami, Leveling, Johannes orcid:0000-0003-0603-4191 , Lawless, Séamus, O'Connor, Alexander, Zhou, Dong, Jones, Gareth J.F. orcid:0000-0003-2923-8365 and Wade, Vincent (2011) Multilingual adaptive search for digital libraries. In: 1st International Conference on Theory and Practice of Digital Libraries (TPDL 2011), 25-29 Sept 2011, Berlin, Germany. ISBN 9783642244681 (2011) BASE Show details 6 Multilingual Adaptive Search for Digital Libraries ; 15th International Conference on Theory and Practice in Digital Libraries (TPDL 2011) LAWLESS, SEAMUS; GHORAB, MOHAMMED RAMI ELHUSSEIN; O'CONNOR, ALEXANDER. - : LNCS, 2011 BASE Show details 7 Towards Multilingual User Models for Personalized Multilingual Information Retrieval ; 1st Workshop on Personalised Multilingual Hypertext Retrieval (PMHR 2011) GHORAB, MOHAMMED RAMI ELHUSSEIN; ZHOU, DONG; STEICHEN, BEN. - : ACM, 2011 BASE Show details 8 New model for system behavior prediction based on belief rule based systems Zhou, Zhi-Jie; Hu, Chang-Hua; Xu, Dong-Ling... In: Information sciences. - New York, NY : Elsevier Science Inc. 180 (2010) 24, 4834-4864 OLC Linguistik Show details 9 Document expansion, query translation and language modeling for ad-hoc IR Leveling, Johannes; Zhou, Dong; Jones, Gareth J.F.... In: Leveling, Johannes orcid:0000-0003-0603-4191 , Zhou, Dong, Jones, Gareth J.F. orcid:0000-0003-2923-8365 and Wade, Vincent (2010) Document expansion, query translation and language modeling for ad-hoc IR. In: Multilingual Information Access Evaluation I, Corfu, Greece. ISBN 978-3-642-15753-0 (2010) BASE Show details 10 Identifying common user behaviour in multilingual search logs Zhou, Dong; Ghorab, M. Rami; Jones, Gareth J.F.... In: Ghorab, M. Rami, Leveling, Johannes orcid:0000-0003-0603-4191 , Zhou, Dong, Jones, Gareth J.F. orcid:0000-0003-2923-8365 and Wade, Vincent (2010) Identifying common user behaviour in multilingual search logs. In: Multilingual Information Access Evaluation I. Text Retrieval Experiments,10th Workshop of the Cross-Language Evaluation Forum . CLEF 2009, Corfu, Greece. (2010) BASE Show details 11 Dual-Space Re-ranking Model for Document Retrieval ; In the Proceedings of the 23rd International Conference on Computational Linguistics, COLING 2010 ZHOU, DONG; WADE, VINCENT PATRICK; LAWLESS, SEAMUS. - 2010 BASE Show details 12 Applying Digital Content Management to Support Localisation O'CONNOR, ALEXANDER; ZHOU, DONG; WADE, VINCENT PATRICK. - 2010 BASE Show details 13 Identifying Common User Behaviour in Multilingual Search Logs ZHOU, DONG; GHORAB, MOHAMMED RAMI ELHUSSEIN; WADE, VINCENT PATRICK. - 2010 BASE Show details 14 A Late Fusion Approach to Cross-Lingual Document Re-ranking ZHOU, DONG; WADE, VINCENT PATRICK; LAWLESS, SEAMUS. - : ACM, 2010 BASE Show details 15 Applying digital content management to support localisation O'Connor, Alexander; Lawless, Séamus; Zhou, Dong... In: O'Connor, Alexander, Lawless, Séamus, Zhou, Dong, Jones, Gareth J.F. orcid:0000-0003-2923-8365 and Wade, Vincent (2009) Applying digital content management to support localisation. Localisation Focus - The International Journal of Localisation, 8 (1). pp. 39-52. ISSN 1649-2358 (2009) BASE Show details 16 TCD-DCU at LogCLEF 2009: An Analysis of Queries, Actions, and Interface Languages GHORAB, MOHAMMED RAMI ELHUSSEIN; ZHOU, DONG. - 2009 BASE Show details 17 HIV/AIDS Knowledge, Attitudes and Behaviors Assessment of Chinese Students: A Questionnaire Study Tan, Xiaodong; Pan, Jingju; Zhou, Dong. - : Molecular Diversity Preservation International (MDPI), 2007 BASE Show details

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