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1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans
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2
Spatially resolved estimation of metabolic oxygen consumption from optical measurements in cortex
In: Neurophotonics (2020)
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3
Enrichment of genetic markers of recent human evolution in educational and cognitive traits.
In: Scientific reports, vol 8, iss 1 (2018)
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Enrichment of genetic markers of recent human evolution in educational and cognitive traits
Abstract: Higher cognitive functions are regarded as one of the main distinctive traits of humans. Evidence for the cognitive evolution of human beings is mainly based on fossil records of an expanding cranium and an increasing complexity of material culture artefacts. However, the molecular genetic factors involved in the evolution are still relatively unexplored. Here, we investigated whether genomic regions that underwent positive selection in humans after divergence from Neanderthals are enriched for genetic association with phenotypes related to cognitive functions. We used genome wide association data from a study of college completion (N = 111,114), one of educational attainment (N = 293,623) and two different studies of general cognitive ability (N = 269,867 and 53,949). We found nominally significant polygenic enrichment of associations with college completion (p = 0.025), educational attainment (p = 0.043) and general cognitive ability (p = 0.015 and 0.025, respectively), suggesting that variants influencing these phenotypes are more prevalent in evolutionarily salient regions. The enrichment remained significant after controlling for other known genetic enrichment factors, and for affiliation to genes highly expressed in the brain. These findings support the notion that phenotypes related to higher order cognitive skills typical of humans have a recent genetic component that originated after the separation of the human and Neanderthal lineages.
Keyword: Article
URL: https://doi.org/10.1038/s41598-018-30387-9
http://www.ncbi.nlm.nih.gov/pubmed/30135563
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105609/
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5
Novel genetic loci associated with hippocampal volume
In: ISSN: 2041-1723 ; EISSN: 2041-1723 ; Nature Communications ; https://hal.archives-ouvertes.fr/hal-01488337 ; Nature Communications, Nature Publishing Group, 2017, 8, pp.13624. ⟨10.1038/ncomms13624⟩ (2017)
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6
Novel genetic loci underlying human intracranial volume identified through genome-wide association
In: ISSN: 1097-6256 ; EISSN: 1546-1726 ; Nature Neuroscience ; https://hal.archives-ouvertes.fr/hal-01382716 ; Nature Neuroscience, Nature Publishing Group, 2016, 19 (12), pp.1569-1582. ⟨10.1038/nn.4398⟩ (2016)
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7
A human neurodevelopmental model for Williams syndrome.
In: Nature, vol 536, iss 7616 (2016)
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8
A human neurodevelopmental model for Williams syndrome.
In: Nature, vol 536, iss 7616 (2016)
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9
Dyslexia and language impairment associated genetic markers influence cortical thickness and white matter in typically developing children.
In: Brain imaging and behavior, vol 10, iss 1 (2016)
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10
Dyslexia and language impairment associated genetic markers influence cortical thickness and white matter in typically developing children.
In: Brain imaging and behavior, vol 10, iss 1 (2016)
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11
Common genetic variants influence human subcortical brain structures.
In: ISSN: 0028-0836 ; EISSN: 1476-4679 ; Nature ; https://hal.archives-ouvertes.fr/hal-01196805 ; Nature, Nature Publishing Group, 2015, 520 (7546), pp.224-9. ⟨10.1038/nature14101⟩ (2015)
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12
Atypical right hemisphere specialization for object representations in an adolescent with specific language impairment.
In: Frontiers in human neuroscience, vol 8, iss 1 FEB (2014)
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13
Atypical Right Hemisphere Specialization for Object Representations in an Adolescent with Specific Language Impairment
Brown, Timothy T.; Erhart, Matthew; Avesar, Daniel. - : Frontiers Media S.A., 2014
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14
Age-related Changes in Tissue Signal Properties Within Cortical Areas Important for Word Understanding in 12- to 19-Month-Old Infants
Travis, Katherine E.; Curran, Megan M.; Torres, Christina. - : Oxford University Press, 2013
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15
Independence of Early Speech Processing from Word Meaning
Travis, Katherine E.; Leonard, Matthew K.; Chan, Alexander M.. - : Oxford University Press, 2013
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16
Independence of Early Speech Processing from Word Meaning
Travis, Katherine E.; Leonard, Matthew K.; Chan, Alexander M.. - : Oxford University Press, 2012
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17
Age-related changes in the neurophysiology of language in adults: Relationship to regional cortical thinning and white matter microstructure
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18
Language proficiency modulates the recruitment of non-classical language areas in bilinguals.
In: PloS one, vol 6, iss 3 (2011)
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19
Right hemisphere has the last laugh: neural dynamics of joke appreciation.
In: Cognitive, affective & behavioral neuroscience, vol 11, iss 1 (2011)
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20
Spatiotemporal Neural Dynamics of Word Understanding in 12- to 18-Month-Old-Infants
Travis, Katherine E.; Leonard, Matthew K.; Brown, Timothy T.. - : Oxford University Press, 2011
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