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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Page: 1 2 3 4 5 Hits 1 – 20 of 87 1 A Bayesian optimization approach for rapidly mapping residual network function in stroke. ... Lorenz, Romy; Johal, Michelle; Dick, Frederic. - : Apollo - University of Cambridge Repository, 2021 BASE Show details 2 A Bayesian optimization approach for rapidly mapping residual network function in stroke Lorenz, Romy; Johal, Michelle; Dick, Frederic... In: Brain (2021) BASE Show details 3 A Bayesian optimization approach for rapidly mapping residual network function in stroke. Lorenz, Romy; Johal, Michelle; Dick, Frederic; Hampshire, Adam; Leech, Robert; Geranmayeh, Fatemeh. - : Oxford University Press (OUP), 2021. : Brain, 2021 Abstract: Post-stroke cognitive and linguistic impairments are debilitating conditions, with limited therapeutic options. Domain-general brain networks play an important role in stroke recovery and characterizing their residual function with functional MRI has the potential to yield biomarkers capable of guiding patient-specific rehabilitation. However, this is challenging as such detailed characterization requires testing patients on multitudes of cognitive tasks in the scanner, rendering experimental sessions unfeasibly lengthy. Thus, the current status quo in clinical neuroimaging research involves testing patients on a very limited number of tasks, in the hope that it will reveal a useful neuroimaging biomarker for the whole cohort. Given the great heterogeneity among stroke patients and the volume of possible tasks this approach is unsustainable. Advancing task-based functional MRI biomarker discovery requires a paradigm shift in order to be able to swiftly characterize residual network activity in individual patients using a diverse range of cognitive tasks. Here, we overcome this problem by leveraging neuroadaptive Bayesian optimization, an approach combining real-time functional MRI with machine-learning, by intelligently searching across many tasks, this approach rapidly maps out patient-specific profiles of residual domain-general network function. We used this technique in a cross-sectional study with 11 left-hemispheric stroke patients with chronic aphasia (four female, age ± standard deviation: 59 ± 10.9 years) and 14 healthy, age-matched control subjects (eight female, age ± standard deviation: 55.6 ± 6.8 years). To assess intra-subject reliability of the functional profiles obtained, we conducted two independent runs per subject, for which the algorithm was entirely reinitialized. Our results demonstrate that this technique is both feasible and robust, yielding reliable patient-specific functional profiles. Moreover, we show that group-level results are not representative of patient-specific results. Whereas controls have highly similar profiles, patients show idiosyncratic profiles of network abnormalities that are associated with behavioural performance. In summary, our study highlights the importance of moving beyond traditional 'one-size-fits-all' approaches where patients are treated as one group and single tasks are used. Our approach can be extended to diverse brain networks and combined with brain stimulation or other therapeutics, thereby opening new avenues for precision medicine targeting a diverse range of neurological and psychiatric conditions. Keyword: Adult; Aged; Bayes Theorem; Brain; Brain Mapping; Computer-Assisted; Female; Humans; Image Interpretation; Machine Learning; Magnetic Resonance Imaging; Male; Middle Aged; Stroke URL: https://www.repository.cam.ac.uk/handle/1810/316163 https://doi.org/10.17863/CAM.63271 BASE Hide details 4 The Multidimensional Battery of Prosody Perception (MBOPP) Jasmin, Kyle; Dick, Frederic; Tierney, Adam Taylor In: Wellcome Open Res (2021) BASE Show details 5 Altered functional connectivity during speech perception in Congenital Amusia Tierney, Adam; Dick, Frederic; Stewart, Lauren. - : eLife Sciences Publications, Ltd, 2020 BASE Show details 6 Altered functional connectivity during speech perception in congenital amusia ... Jasmin, Kyle; Dick, Frederic; Stewart, Lauren. - : Birkbeck College, University of London, 2020 BASE Show details 7 Altered functional connectivity during speech perception in congenital amusia Jasmin, Kyle; Dick, Frederic; Stewart, Lauren... In: eLife (2020) BASE Show details 8 Tailored perception: individuals’ speech and music perception strategies fit their perceptual abilities Dick, Frederic; Tierney, Adam; Jasmin, Kyle. - : American Psychological Association, 2019 BASE Show details 9 Speech-in-speech perception, non-verbal selective attention, and musical training Tierney, Adam; Dick, Frederic; Rosen, S.. - : American Psychological Association, 2019 BASE Show details 10 Multidimensional Battery of Prosody Perception ... Jasmin, Kyle; Dick, Frederic; Tierney, Adam. - : Birkbeck College, University of London, 2019 BASE Show details 11 What underlies the emergence of stimulus- and domain-specific neural responses? Commentary on Hernandez, Claussenius-Kalman, Ronderos, Castilla-Earls, Sun, Weiss, & Young (2018) Dick, Frederic; Krishnan, S.. - : Elsevier, 2018 BASE Show details 12 Dimension-selective attention as a possible driver of dynamic, context-dependent re-weighting in speech processing Dick, Frederic; Tierney, Adam; Guerra, G.. - : Elsevier, 2018 BASE Show details 13 Neural representation of vowel formants in tonotopic auditory cortex Fisher, J.; Dick, Frederic; Levy, D.. - : Elsevier, 2018 BASE Show details 14 Dimension-selective attention as a possible driver of dynamic, context-dependent re-weighting in speech processing Holt, Lori L.; Tierney, Adam T.; Guerra, Giada. - 2018 BASE Show details 15 Neural representation of vowel formants in tonotopic auditory cortex Fisher, Julia M.; Dick, Frederic K.; Levy, Deborah F.. - 2018 BASE Show details 16 Fractionating nonword repetition: the contributions of short-term memory and oromotor praxis are different Carey, Daniel; Karmiloff-Smith, Annette; Krishnan, Saloni. - : Public Library of Science, 2017 BASE Show details 17 Functional and quantitative MRI mapping of somatomotor representations of human supralaryngeal vocal tract Carey, Daniel; Krishnan, Saloni; Callaghan, M.F.. - : Oxford Journals, 2017 BASE Show details 18 Fractionating nonword repetition:The contributions of short-term memory and oromotor praxis are different Krishnan, Saloni; Alcock, Katherine J.; Carey, Daniel. - 2017 BASE Show details 19 Fractionating nonword repetition: The contributions of short-term memory and oromotor praxis are different Krishnan, Saloni; Alcock, Katherine J.; Carey, Daniel. - : Public Library of Science, 2017 BASE Show details 20 Functional and Quantitative MRI Mapping of Somatomotor Representations of Human Supralaryngeal Vocal Tract Carey, Daniel; Krishnan, Saloni; Callaghan, Martina F.. - : Oxford University Press, 2017 BASE Show details Page: 1 2 3 4 5

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