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    • Pan, Tao (3)
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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Hits 1 – 4 of 4 1 The Role of the P1 Latency in Auditory and Speech Performance Evaluation in Cochlear Implanted Children Xiong, Shan; Jiang, Liwei; Wang, Yu... In: Neural Plast (2022) BASE Show details 2 Cross-editing by a tRNA synthetase allows vertebrates to abundantly express mischargeable tRNA without causing mistranslation Chen, Meirong; Kuhle, Bernhard; Diedrich, Jolene; Liu, Ze; Moresco, James J; Yates III, John R; Pan, Tao; Yang, Xiang-Lei In: Nucleic Acids Res (2020) Abstract: The accuracy in pairing tRNAs with correct amino acids by aminoacyl-tRNA synthetases (aaRSs) dictates the fidelity of translation. To ensure fidelity, multiple aaRSs developed editing functions that remove a wrong amino acid from tRNA before it reaches the ribosome. However, no specific mechanism within an aaRS is known to handle the scenario where a cognate amino acid is mischarged onto a wrong tRNA, as exemplified by AlaRS mischarging alanine to G4:U69-containing tRNA(Thr). Here, we report that the mischargeable G4:U69-containing tRNA(Thr) are strictly conserved in vertebrates and are ubiquitously and abundantly expressed in mammalian cells and tissues. Although these tRNAs are efficiently mischarged, no corresponding Thr-to-Ala mistranslation is detectable. Mistranslation is prevented by a robust proofreading activity of ThrRS towards Ala-tRNA(Thr). Therefore, while wrong amino acids are corrected within an aaRS, a wrong tRNA is handled in trans by an aaRS cognate to the mischarged tRNA species. Interestingly, although Ala-tRNA(Thr) mischarging is not known to occur in bacteria, Escherichia coli ThrRS also possesses robust cross-editing ability. We propose that the cross-editing activity of ThrRS is evolutionarily conserved and that this intrinsic activity allows G4:U69-containing tRNA(Thr) to emerge and be preserved in vertebrates to have alternative functions without compromising translational fidelity. Keyword: Chemical Biology and Nucleic Acid Chemistry URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337962/ http://www.ncbi.nlm.nih.gov/pubmed/32484512 https://doi.org/10.1093/nar/gkaa469 BASE Hide details 3 Untersuchungen zu Lexikon und Metrik des Tocharischen Pan, Tao [Verfasser]; Hackstein, Olav [Akademischer Betreuer]. - München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2019 DNB Subject Category Language Show details 4 Untersuchungen zu Lexikon und Metrik des Tocharischen ... Pan, Tao. - : Ludwig-Maximilians-Universität München, 2019 BASE Show details

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