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Genome-wide association study reveals new insights into the heritability and genetic correlates of developmental dyslexia
In: ISSN: 1359-4184 ; EISSN: 1476-5578 ; Molecular Psychiatry ; https://hal.archives-ouvertes.fr/hal-02976104 ; Molecular Psychiatry, Nature Publishing Group, 2020, ⟨10.1038/s41380-020-00898-x⟩ (2020)
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Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia
In: ISSN: 2158-3188 ; EISSN: 2158-3188 ; Translational Psychiatry ; https://hal.archives-ouvertes.fr/hal-02158502 ; Translational Psychiatry, Nature Pub. Group, 2019, 9, pp.77. ⟨10.1038/s41398-019-0402-0⟩ (2019)
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Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia ...
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Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia
In: Translational Psychiatry, 9 (1) (2019)
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Genomic imprinting as a window into human language evolution
Abstract: Funding: S.P. is a Royal Society University Research Fellow. A.G. is funded by a Natural Environment Research Council Independent Research Fellowship (NE/K009524/1) and a European Research Council Consolidator Grant (771387). ; Humans spend large portions of their time and energy talking to one another, yet it remains unclear whether this activity is primarily selfish or altruistic. Here, it is shown how parent‐of‐origin specific gene expression—or “genomic imprinting”—may provide an answer to this question. First, it is shown why, regarding language, only altruistic or selfish scenarios are expected. Second, it is pointed out that an individual's maternal‐origin and paternal‐origin genes may have different evolutionary interests regarding investment into language, and that this intragenomic conflict may drive genomic imprinting which—as the direction of imprint depends upon whether investment into language is relatively selfish or altruistic—may be used to discriminate between these two possibilities. Third, predictions concerning the impact of various mutations and epimutations at imprinted loci on language pathologies are derived. In doing so, a framework is developed that highlights avenues for using intragenomic conflicts to investigate the evolutionary drivers of language. ; Publisher PDF ; Peer reviewed
Keyword: Biochemistry; Genetics and Molecular Biology(all); Genomic imprinting; Inclusive fitness; Intragenomic conflict; Kin selection; Language evolution; Language impairement; Parent-of-origin effects; QH426; QH426 Genetics; T-NDAS
URL: https://doi.org/10.1002/bies.201800212
http://hdl.handle.net/10023/17765
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Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia
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Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia
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8
The neuronal migration hypothesis of dyslexia : a critical evaluation 30 years on
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The neuronal migration hypothesis of dyslexia: A critical evaluation 30 years on
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The neuronal migration hypothesis of dyslexia: A critical evaluation 30 years on
Guidi, Luiz G.; Velayos‐Baeza, Antonio; Martinez‐Garay, Isabel. - : John Wiley and Sons Inc., 2018
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Further evidence for a parent-of-origin effect at the NOP9 locus on language-related phenotypes
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Further evidence for a parent-of-origin effect at the NOP9 locus on language-related phenotypes
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13
Further evidence for a parent-of-origin effect at the NOP9 locus on language-related phenotypes
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14
Further evidence for a parent-of-origin effect at the NOP9 locus on language-related phenotypes
Pettigrew, Kerry A.; Frinton, Emily; Nudel, Ron. - : BioMed Central Ltd., 2016
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15
Copy Number Variation Screen Identifies a Rare De Novo Deletion at Chromosome 15q13.1-13.3 in a Child with Language Impairment
Pettigrew, Kerry A.; Reeves, Emily; Leavett, Ruth. - : Public Library of Science, 2015
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Copy number variation screen identifies a rare de novo deletion at chromosome 15q13.1-13.3 in a child with language impairment
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Genome-wide screening for DNA variants associated with reading and language traits
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Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort
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Genome-wide association analyses of child genotype effects and parent-of-origin effects in specific language impairment
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Copy number variation screen identifies a rare de novo deletion at chromosome 15q13.1-13.3 in a child with language impairment
Pettigrew, Kerry A.; Reeves, Emily; Leavett, Ruth. - : Public Library of Science, 2015
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