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1
Congenital hearing loss
Abstract: Congenital hearing loss (hearing loss present at birth) is one of the most prevalent chronic conditions in children. In the majority of developed countries, neonatal hearing-screening programmes enable early detection; early intervention will prevent delays in speech and language development and have long-lasting beneficial effects on social and emotional development and quality of life. A hearing loss diagnosis is usually followed by a search for an underlying aetiology. Congenital hearing loss might be attributed to environmental and prenatal factors, which prevail in low-income settings; congenital infections, particularly cytomegalovirus, are also a common risk factor for hearing loss. Genetic causes probably account for the majority of cases in developed countries; mutations can affect any component of the hearing pathway, in particular inner ear homeostasis (endolymph production and maintenance) and mechano-electrical transduction (conversion of a mechanical stimulus into electrochemical activity). Once the underlying cause of hearing loss is established, it might direct therapeutic decision-making and guide prevention and (genetic) counseling. Management options include specific antimicrobial therapies, surgical treatment of cranio-facial abnormalities and hearing aids. An improved understanding of the pathophysiology and molecular mechanisms underlying hearing loss and increased awareness of recent advances in genetic testing will promote the development of new treatment and screening strategies.
Keyword: Article
URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675031/
https://doi.org/10.1038/nrdp.2016.94
http://www.ncbi.nlm.nih.gov/pubmed/28079113
BASE
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2
Out of Amazonia: Late-Holocene climate change and the Tupi–Guarani trans-continental expansion
BASE
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3
Out of Amazonia: late-Holocene climate change and the Tupi–Guarani trans-continental expansion
Iriarte, Jose; Smith, Richard J.; de Souza, Jonas G.. - : Sage Publications, 2017
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4
Divination in Ch'ing dynasty China
In: Cosmology, ontology, and human efficacy (Honolulu, 1993 p.), p. 141-178
MPI für Psycholinguistik
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5
Cosmology, ontology, and human efficacy : essays in Chinese thought
Smith, Richard J.; Kwok, D.W.Y.. - Honolulu : University of Hawai'i Press, 1993 p.
MPI für Psycholinguistik
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