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1
Developmental Outcomes for Children at High Risk of Dyslexia and Children With Developmental Language Disorder
Snowling, MJ; Nash, HM; Gooch, DC. - : Wiley, 2019
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2
Dyslexia and Developmental Language Disorder: comorbid disorders with distinct effects on reading comprehension
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3
Developmental outcomes for children at high risk of dyslexia and children with developmental language disorder
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4
Longitudinal relationships between speech perception, phonological skills and reading in children at high-risk of dyslexia
Nash, HM; Hulme, C; Snowling, MJ. - : Wiley, 2018
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5
Phase 2 of CATALISE: a multinational and multidisciplinary Delphi consensus study of problems with language development: Terminology
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6
Phase 2 of CATALISE: a multinational and multidisciplinary Delphi consensus study of problems with language development: Terminology
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7
Phase 2 of CATALISE: a multinational and multidisciplinary Delphi consensus study of problems with language development: Terminology
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8
Phase 2 of CATALISE: a multinational and multidisciplinary Delphi consensus study of problems with language development: Terminology
Bishop, DVM; Greenhalgh, T; Snowling, MJ. - : Wiley for Association for Child and Adolescent Mental Health (ACAMH), 2017
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9
Phase 2 of CATALISE: a multinational and multidisciplinary Delphi consensus study of problems with language development: Terminology
Thompson, PA; Snowling, , MJ; Greenhalgh, T. - : Wiley for Association for Child and Adolescent Mental Health (ACAMH), 2017
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10
The development of executive function and language skills in the early school years
Gooch, D; Thompson, P; Nash, HM. - : Wiley, 2016
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11
Language profiles and literacy outcomes of children with resolving, emerging, or persisting language impairments
Snowling, MJ; Duff, FJ; Nash, HM. - : Wiley, 2016
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12
Oral language skills intervention in pre-school-a cautionary tale
In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; CrossRef (2016)
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13
Same same, but different: Word and sentence reading in German and English
In: Symplectic Elements at Oxford ; Scopus (http://www.scopus.com/home.url) ; ORA review team (2016)
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14
Precursors of reading difficulties in Czech and Slovak children at-risk of dyslexia
In: Symplectic Elements at Oxford ; Added by author ; ORA review team (2016)
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15
CATALISE: a multinational and multidisciplinary delphi consensus study. Identifying language impairments in children
In: Symplectic Elements at Oxford ; Added by author ; ORA review team (2016)
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16
Further evidence for a parent-of-origin effect at the NOP9 locus on language-related phenotypes
In: Symplectic Elements at Oxford ; Added by author ; ORA review team (2016)
Abstract: Background: Specific Language Impairment (SLI) is a common neurodevelopmental disorder, observed in 5-10% of children. Family and twin studies suggest a strong genetic component, but relatively few candidate genes have been reported to date. A recent genome-wide association study (GWAS) described the first statistically significant association specifically for a SLI cohort between a missense variant (rs4280164) in the NOP9 gene and language-related phenotypes under a parent-of-origin model. Replications of these findings are particularly challenging because the availability of parental DNA is required. Methods: We used two independent family-based cohorts characterised with reading- and language-related traits: a longitudinal cohort (n = 106 informative families) including children with language and reading difficulties and a nuclear family cohort (n = 264 families) selected for dyslexia. Results: We observed association with language-related measures when modelling for parent-of-origin effects at the NOP9 locus in both cohorts: minimum P = 0.001 for phonological awareness with a paternal effect in the first cohort and minimum P = 0.0004 for irregular word reading with a maternal effect in the second cohort. Allelic and parental trends were not consistent when compared to the original study. Conclusions: A parent-of-origin effect at this locus was detected in both cohorts, albeit with different trends. These findings contribute in interpreting the original GWAS report and support further investigations of the NOP9 locus and its role in language-related traits. A systematic evaluation of parent-of-origin effects in genetic association studies has the potential to reveal novel mechanisms underlying complex traits.
Keyword: candidate gene; dyslexia; genetic association; language impairment; parent-of-origin
URL: https://doi.org/10.1186/s11689-016-9157-6
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17
CATALISE: A multinational and multidisciplinary Delphi consensus study. Identifying language impairments in children
In: PLoS ONE , 11 (7) , Article e0158753. (2016) (2016)
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18
CATALISE: A multinational and multidisciplinary Delphi consensus study. Identifying language impairments in children
Baird, G; Carter, G; Westerveld, M. - : Public Library of Science, 2016
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19
The Foundations of Literacy Development in Children at Familial Risk of Dyslexia
Hulme, C; Nash, HM; Gooch, D. - : Association for Psychological Science, 2015
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20
Developmental dyslexia: predicting individual risk
Thompson, PA; Hulme, C; Nash, HM. - : Wiley, 2015
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