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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Hits 1 – 2 of 2 1 The Trans-Ancestral Genomic Architecture of Glycemic Traits Chen, Ji; Spracklen, Cassandra N.; Marenne, Gaëlle... In: Nat Genet (2021) BASE Show details 2 Imprint of assortative mating on the human genome Yengo, Loic; Robinson, Matthew R.; Keller, Matthew C.; Kemper, Kathryn E.; Yang, Yuanhao; Trzaskowski, Maciej; Gratten, Jacob; Turley, Patrick; Cesarini, David; Benjamin, Daniel J.; Wray, Naomi R.; Goddard, Michael E.; Yang, Jian; Visscher, Peter M.. - : Nature Publishing Group, 2018 Abstract: Preference for mates with similar phenotypes; that is, assortative mating, is widely observed in humans and has evolutionary consequences. Under Fisher's classical theory, assortative mating is predicted to induce a signature in the genome at trait-associated loci that can be detected and quantified. Here, we develop and apply a method to quantify assortative mating on a specific trait by estimating the correlation (θ) between genetic predictors of the trait from single nucleotide polymorphisms on odd- versus even-numbered chromosomes. We show by theory and simulation that the effect of assortative mating can be quantified in the presence of population stratification. We applied this approach to 32 complex traits and diseases using single nucleotide polymorphism data from ~400,000 unrelated individuals of European ancestry. We found significant evidence of assortative mating for height (θ = 3.2%) and educational attainment (θ = 2.7%), both of which were consistent with theoretical predictions. Overall, our results imply that assortative mating involves multiple traits and affects the genomic architecture of loci that are associated with these traits, and that the consequence of mate choice can be detected from a random sample of genomes. Keyword: 2802 Behavioral Neuroscience; 3205 Experimental and Cognitive Psychology; 3207 Social Psychology; Common; Genotype; Height; Loci; Size; Twins; Wide Association URL: https://espace.library.uq.edu.au/view/UQ:3579f6b BASE Hide details

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