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Simple Search
Hits 1 – 10 of 10
1
Multi-Smart and Scalable Bioligands-Free Nanomedical Platform for Intratumorally Targeted Tambjamine Delivery, a Difficult to Administrate Highly Cytotoxic Drug
Pérez-Hernández, Marta
;
Cuscó, Cristina
;
Benítez-García, Cristina
. - 2021
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2
Artificial Intelligence and its future potential in lung cancer screening
Joy Mathew, Christopher
;
David, Ashwini Maria
;
Joy Mathew, Chris Mariya
. - : IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund, 2020
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3
Natural Language Processing of Clinical Notes on Chronic Diseases: Systematic Review
Sheikhalishahi, Seyedmostafa
;
Miotto, Riccardo
;
Dudley, Joel T
...
In: Sheikhalishahi, Seyedmostafa; Miotto, Riccardo; Dudley, Joel T; Lavelli, Alberto; Rinaldi, Fabio; Osmani, Venet (2019). Natural Language Processing of Clinical Notes on Chronic Diseases: Systematic Review. JMIR Medical Informatics, 7(2):e12239. (2019)
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4
Deaf patient-provider communication and lung cancer screening: Health Information National Trends survey in American Sign Language (HINTS-ASL).
Kushalnagar, P
;
Engelman, Alina
;
Sadler, G
In: Patient education and counseling, vol 101, iss 7 (2018)
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5
Nitric Oxide and Cyclic GMP Signaling in Cancer Therapy
Dorsey, Armond
;
Murad, MD, PhD, Ferid
;
Bian, MD, PhD, Ka
In: Journal of Health Disparities Research and Practice (2016)
Abstract:
The nitric oxide-3’,5’-cyclic guanosine monophosphate signaling pathway (NO-cGMP signaling pathway) is a well-known signal transduction pathway which elicits several physiological processes including: cell proliferation, vasodilation, cardiac protection, etc. In this pathway, NO binds to the ferrous heme of histidine-105 on the prosthetic heme of the β1 subunit of soluble guanylyl cyclase, resulting in the production of cGMP. This pathway, however, is inhibited in certain cancer cells—as observed in glioma cell lines. As a result, the production of cGMP is reduced. This mechanism may facilitate uncontrolled tumor cell growth. The cancers under research—lung carcinoma, glioma, and pancreatic carcinoma—are all highly malignant cancers with low survival rates and few effective treatments. To save the lives of 213,920+ U.S. patients expected to die from these diseases, new therapies must be developed. We hypothesize that regulating the expression of sGC via pharmacology and/or genetic manipulation in the aforementioned cancers—which possess lower expression levels of subunits sGCα1 and sGCβ1—will increase cGMP synthesis. As experimental approach, the H460 human large lung cell carcinoma cell line, the PA-TU-8988 human pancreatic adenocarcinoma cell line, and the U87 human glioma cell line were cultured in 2D and 3D culture. MTT assay, qRT-PCR, Western Blot, and ImageJ analysis were utilized to assess cell proliferation, detection and quantification of genes and proteins expression, and size of colonies in 3D culture, respectively. Research is still continuing; results are not final. The expected results after treatment are: reduced cancer cell viability, enhanced sGC expression, presence of cGMP, and inhibited tumor growth
Keyword:
and Multicultural Education
;
Bilingual
;
cancer therapy
;
cGMP
;
Community College Leadership
;
glioma
;
Higher Education
;
Immune System Diseases
;
lung carcinoma
;
Medicine and Health Sciences
;
Multilingual
;
pancreatic adenocarcinoma
;
Public Health
;
Translational Medical Research
;
Virus Diseases
URL:
https://digitalscholarship.unlv.edu/cgi/viewcontent.cgi?article=1536&context=jhdrp
https://digitalscholarship.unlv.edu/jhdrp/vol9/iss5/6
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6
Investigating the Role of the Retinoblastoma Protein in the Expression of Immunosuppressive Factors
Pérez Deliz, Felipe
;
Santiago-Cardona, PhD, Pedro
;
González, PhD, J.
...
In: Journal of Health Disparities Research and Practice (2016)
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7
Disseminating tobacco control information to Asians and Pacific Islanders.
Tat, John
;
Nguy, Mike
;
Tong, Eric K
...
In: Journal of cancer education : the official journal of the American Association for Cancer Education, vol 30, iss 1 (2015)
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8
Timeliness of care in patients with lung cancer: a systematic review
Olsson, J K
;
Schultz, E M
;
Gould, M K
. - : BMJ Publishing Group Ltd, 2009
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9
Diagnostic accuracy of tumour markers for malignant pleural effusion: a meta-analysis
Liang, Q-L
;
Shi, H-Z
;
Qin, X-J
. - : BMJ Publishing Group Ltd, 2008
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10
A Computational Linguistics Approach to the Identification of Biological Factors that Contribute to the Development and Progression of Lung Cancer
C. M. Frenz
;
C. Luo
;
E. Urgard
...
In: http://world-comp.org/p2011/BIC3561.pdf
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