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Cortical microstructure in primary progressive aphasia: a multicenter study.
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In: Alzheimer's research & therapy, vol 14, iss 1 (2022)
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| 2 |
Neural substrates of verbal repetition deficits in primary progressive aphasia.
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Breakdowns in Informativeness of Naturalistic Speech Production in Primary Progressive Aphasia
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In: MDPI (2021)
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Breakdowns in Informativeness of Naturalistic Speech Production in Primary Progressive Aphasia
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In: Multidisciplinary Digital Publishing Institute (2021)
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Abstract:
“Functional communication” refers to an individual’s ability to communicate effectively in his or her everyday environment, and thus is a paramount skill to monitor and target therapeutically in people with aphasia. However, traditional controlled-paradigm assessments commonly used in both research and clinical settings often fail to adequately capture this ability. In the current study, facets of functional communication were measured from picture-elicited speech samples from 70 individuals with mild primary progressive aphasia (PPA), including the three variants, and 31 age-matched controls. Building upon methods recently used by Berube et al. (2019), we measured the informativeness of speech by quantifying the content of each patient’s description that was relevant to a picture relative to the total amount of speech they produced. Importantly, form-based errors, such as mispronunciations of words, unusual word choices, or grammatical mistakes are not penalized in this approach. We found that the relative informativeness, or efficiency, of speech was preserved in non-fluent variant PPA patients as compared with controls, whereas the logopenic and semantic variant PPA patients produced significantly less informative output. Furthermore, reduced informativeness in the semantic variant is attributable to a lower production of content units and a propensity for self-referential tangents, whereas for the logopenic variant, a lower production of content units and relatively ”empty” speech and false starts contribute to this reduction. These findings demonstrate that functional communication impairment does not uniformly affect all the PPA variants and highlight the utility of naturalistic speech analysis for measuring the breakdown of functional communication in PPA.
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URL: https://hdl.handle.net/1721.1/131325
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| 5 |
A category-selective semantic memory deficit for animate objects in semantic variant primary progressive aphasia
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In: Brain Commun (2021)
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| 6 |
Neural substrates of verbal repetition deficits in primary progressive aphasia
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In: Brain Commun (2021)
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| 7 |
New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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| 8 |
New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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| 9 |
Atrophy in Distinct Corticolimbic Networks Subserving Socioaffective Behavior in Semantic-Variant Primary Progressive Aphasia
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In: Dement Geriatr Cogn Disord (2020)
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| 10 |
Word retrieval across the biomarker-confirmed Alzheimer’s disease syndromic spectrum
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In: Neuropsychologia (2020)
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| 11 |
Altered functional connectivity of cortical networks in semantic variant Primary Progressive Aphasia
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In: Neuroimage Clin (2020)
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| 12 |
Longitudinal structural and metabolic changes in frontotemporal dementia
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In: Neurology (2020)
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| 13 |
Visual cognition in non-amnestic Alzheimer's disease: Relations to tau, amyloid, and cortical atrophy
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| 14 |
Quantification of motor speech impairment and its anatomic basis in primary progressive aphasia
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| 15 |
Cerebrospinal fluid biomarkers predict frontotemporal dementia trajectory.
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In: Annals of clinical and translational neurology, vol 5, iss 10 (2018)
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Cerebrospinal fluid biomarkers predict frontotemporal dementia trajectory.
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In: Annals of clinical and translational neurology, vol 5, iss 10 (2018)
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| 17 |
Flortaucipir tau PET imaging in semantic variant primary progressive aphasia
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| 18 |
Executive Dysfunction Contributes to Verbal Encoding and Retrieval Deficits in Posterior Cortical Atrophy
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Functional connectivity in category-selective brain networks after encoding predicts subsequent memory: Category selective connectivity predicts memory
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Focal temporal pole atrophy and network degeneration in semantic variant primary progressive aphasia
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