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Brain-behavior relationships in incidental learning of non-native phonetic categories
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In: Brain Lang (2019)
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Neurochemistry Predicts Convergence of Written and Spoken Language: A Proton Magnetic Resonance Spectroscopy Study of Cross-Modal Language Integration
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Individual Differences in Reading Skill Are Related to Trial-by-Trial Neural Activation Variability in the Reading Network
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The BDNF Val66Met Polymorphism Influences Reading Ability and Patterns of Neural Activation in Children
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Universal brain signature of proficient reading: Evidence from four contrasting languages.
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In: Proceedings of the National Academy of Sciences of the United States of America, vol 112, iss 50 (2015)
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Functionally integrated neural processing of linguistic and talker information: An event-related fMRI and ERP study
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Universal brain signature of proficient reading: Evidence from four contrasting languages
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Structural brain differences in school-age children with residual speech sound errors.
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In: Brain and language, vol 128, iss 1 (2014)
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Glutamate and choline levels predict individual differences in reading ability in emergent readers.
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In: The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 34, iss 11 (2014)
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Glutamate and Choline Levels Predict Individual Differences in Reading Ability in Emergent Readers
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Structural brain differences in school-age children with residual speech sound errors
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The BDNF Val66Met Polymorphism Influences Reading Ability and Patterns of Neural Activation in Children.
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Abstract:
Understanding how genes impact the brain's functional activation for learning and cognition during development remains limited. We asked whether a common genetic variant in the BDNF gene (the Val66Met polymorphism) modulates neural activation in the young brain during a critical period for the emergence and maturation of the neural circuitry for reading. In animal models, the bdnf variation has been shown to be associated with the structure and function of the developing brain and in humans it has been associated with multiple aspects of cognition, particularly memory, which are relevant for the development of skilled reading. Yet, little is known about the impact of the Val66Met polymorphism on functional brain activation in development, either in animal models or in humans. Here, we examined whether the BDNF Val66Met polymorphism (dbSNP rs6265) is associated with children's (age 6-10) neural activation patterns during a reading task (n = 81) using functional magnetic resonance imaging (fMRI), genotyping, and standardized behavioral assessments of cognitive and reading development. Children homozygous for the Val allele at the SNP rs6265 of the BDNF gene outperformed Met allele carriers on reading comprehension and phonological memory, tasks that have a strong memory component. Consistent with these behavioral findings, Met allele carriers showed greater activation in reading-related brain regions including the fusiform gyrus, the left inferior frontal gyrus and left superior temporal gyrus as well as greater activation in the hippocampus during a word and pseudoword reading task. Increased engagement of memory and spoken language regions for Met allele carriers relative to Val/Val homozygotes during reading suggests that Met carriers have to exert greater effort required to retrieve phonological codes. ; P01 HD001994, P50 HD052120, R01 HD048830, R03 HD053409 ; This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995017.
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Keyword:
Brain-Derived Neurotrophic Factor/genetics; Child; Cognition/physiology; Female; Frontal Lobe/diagnostic imaging; Frontal Lobe/physiology; Gene Frequency; Genotype; Hippocampus/diagnostic imaging; Hippocampus/physiology; Humans; Magnetic Resonance Imaging; Male; Memory/physiology; Neurons/physiology; Polymorphism; Reading; Single Nucleotide/genetics
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URL: https://doi.org/10.1371/journal.pone.0157449 http://diginole.lib.fsu.edu/islandora/object/fsu%3A600786/datastream/TN/view/BDNF%20Val66Met%20Polymorphism%20Influences%20Reading%20Ability%20and%20Patterns%20of%20Neural%20Activation%20in%20Children.jpg http://purl.flvc.org/fsu/fd/FSU_pmch_27551971
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