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STR-palatalisation in Edinburgh accent: A sociophonetic study of a sound change in progress
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Edinburgh
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In: http://www.audio-lingua.eu/spip.php?article1618 (2011)
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A discourse approach to theorising HRD: opening a discursive space
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27 |
Helping Eastern students to master Western critical thinking
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Teenagers' acquisition of variation: A comparison of locally-born and migrant teens' realisation of English (ing) in Edinburgh and London
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La "poetica dell'incontrollabilità": l'Endymion di Keats, la lingua e i periodici romantici ; The "Poetics of Uncontrollability": Keats's "Endymion", Language and Romantic Periodicals
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ANSELMO, ANNA. - : Università Cattolica del Sacro Cuore, 2011. : MILANO, 2011
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Developing Enterprising People through an Innovative Enterprise Degree: An Analysis of the Students' Evolving Perceptions and Attitudes
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Extensive reading is a form of reading instruction. Its definition and purpose areJunko Yamashita
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In: http://www.gsid.nagoya-u.ac.jp/yamashita/graduates/yamashita2008.pdf (2008)
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Evaluating a Virtual Learning Environment in Medical Education
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Ellaway, Rachel Helen. - : The University of Edinburgh. College of Medicine and Veterinary Medicine. Directorate of Undergraduate Learning and Teaching, 2006
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Primary varicose veins: Altered transcription of VEGF and its receptors (KDR, flt-1, soluble flt-1) with sapheno-femoral junction incompetence
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In: EUR J VASC ENDOVASC , 27 (3) 259 - 268. (2004) (2004)
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Abstract:
Objective. Loss of regulation of vascular endothelial growth factor (VEGF) production and action disturbs vascular homeostasis leading to pathology. Primary varicose veins (VVs) demonstrate aberrant production/release of VEGF Our aim was to examine transcription of genes for VEGF (VEGF(121)/VEGF(165)) and its receptors WDR, flt-1, s.flt-1) in VVs, in relation to underlying venous incompetence.Materials and methods. Samples of varicose (n = 83, 18 patients) or normal (n = 14,five subjects) great saphenous vein were divided into segments, determined by anatomical position from the sapheno-femoral junction (SFJ). SFJ and segmental incompetence were determined from duplex scans. Gene transcripts were amplified by RT-PCR, analysed by scanning densitometry, and the levels of transcription determined by ratio to control gene GADPH-3 (GAP-3).Results. VEGF(121/165), KDR and flt-1 transcription was elevated in VVs overall (p < 0.001), and in VVs with an incompetent SFJ (p < 0.001), but not when the SFJ was functional; s.flt-1 was unaltered. Notably, gene transcription was unaffected by segmental position, or incompetence. Position below the SFJ correlated with increased transcription of s.flt-1 when the SFJ was incompetent (p < 0.04), and s.flt-1 and VEGF(121) when the segment was incompetent (p < 0.03).Conclusions. SFJ incompetence is associated with altered transcription of VEGF and its receptors reflecting an aetiological mechanism or later stage of disease development. Altered VEGF(121) and s.flt-1 transcription may be an early event in varicogenesis.
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Keyword:
CHRONIC VENOUS INSUFFICIENCY; DISEASE; EDINBURGH VEIN; ENDOTHELIAL GROWTH-FACTOR; flt-1; GENERAL-POPULATION; HYPOXIA; KDR; LONG SAPHENOUS-VEIN; NITRIC-OXIDE; PLASMA; REFLUX; s.flt-1; sapheno-femoral junction; varicose veins; vascular endothelial growth factor; venous incompetence
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URL: http://discovery.ucl.ac.uk/1313016/
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THEORY AND METHODS Self report in clinical and epidemiological studies with non- English speakers: the challenge of language and culture
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A generic approach to software support for linguistic annotation using XML
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In: http://www.cogsci.ed.ac.uk/~dmck/Papers/carletta-specom.ps (2002)
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