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Ensemble of Deep Convolutional Neural Networks for Classification of Early Barrett’s Neoplasia Using Volumetric Laser Endomicroscopy
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In: Applied Sciences ; Volume 9 ; Issue 11 (2019)
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Anomalies of the Portal Venous System in Dogs and Cats as Seen on Multidetector-Row Computed Tomography: An Overview and Systematization Proposal
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In: Veterinary Sciences ; Volume 6 ; Issue 1 (2019)
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Predictors for functional and anatomic outcomes in macular edema secondary to non-infectious uveitis
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The clinico-metabolic correlates of language impairment in corticobasal syndrome and progressive supranuclear palsy
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In: ISSN: 2213-1582 ; NeuroImage: Clinical (2019) P. 102009 (2019)
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Focal Hypoperfusion in Acute Ischemic Stroke Perfusion CT: Clinical and Radiologic Predictors and Accuracy for Infarct Prediction.
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In: AJNR. American journal of neuroradiology, vol. 40, no. 3, pp. 483-489 (2019)
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Parietal involvement in the semantic variant of primary progressive aphasia with Alzheimer's disease CSF profile
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In: ISSN: 1387-2877 ; Journal of Alzheimer's Disease ; https://hal.sorbonne-universite.fr/hal-01928504 ; Journal of Alzheimer's Disease, IOS Press, 2018, 66 (1), pp.271 - 280. ⟨10.3233/JAD-180087⟩ (2018)
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An Automated Pipeline for the Analysis of PET Data on the Cortical Surface
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In: ISSN: 1662-5196 ; Frontiers in Neuroinformatics ; https://hal.inria.fr/hal-01950933 ; Frontiers in Neuroinformatics, Frontiers, 2018, 12, ⟨10.3389/fninf.2018.00094⟩ (2018)
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Interpretation of HRCT Scans in the Diagnosis of IPF: Improving Communication Between Pulmonologists and Radiologists.
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In: Lung, vol 196, iss 5 (2018)
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Evidence Supporting LI-RADS Major Features for CT- and MR Imaging-based Diagnosis of Hepatocellular Carcinoma: A Systematic Review.
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In: Radiology, vol 286, iss 1 (2018)
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Rates of Amyloid Imaging Positivity in Patients With Primary Progressive Aphasia.
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Santos-Santos, Miguel A; Rabinovici, Gil D; Iaccarino, Leonardo; Ayakta, Nagehan; Tammewar, Gautam; Lobach, Iryna; Henry, Maya L; Hubbard, Isabel; Mandelli, Maria Luisa; Spinelli, Edoardo; Miller, Zachary A; Pressman, Peter S; O'Neil, James P; Ghosh, Pia; Lazaris, Andreas; Meyer, Marita; Watson, Christa; Yoon, Soo Jin; Rosen, Howard J; Grinberg, Lea; Seeley, William W; Miller, Bruce L; Jagust, William J; Gorno-Tempini, Maria Luisa
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In: JAMA neurology, vol 75, iss 3 (2018)
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Abstract:
Importance:The ability to predict the pathology underlying different neurodegenerative syndromes is of critical importance owing to the advent of molecule-specific therapies. Objective:To determine the rates of positron emission tomography (PET) amyloid positivity in the main clinical variants of primary progressive aphasia (PPA). Design, Setting, and Participants:This prospective clinical-pathologic case series was conducted at a tertiary research clinic specialized in cognitive disorders. Patients were evaluated as part of a prospective, longitudinal research study between January 2002 and December 2015. Inclusion criteria included clinical diagnosis of PPA; availability of complete speech, language, and cognitive testing; magnetic resonance imaging performed within 6 months of the cognitive evaluation; and PET carbon 11-labeled Pittsburgh Compound-B or florbetapir F 18 brain scan results. Of 109 patients referred for evaluation of language symptoms who underwent amyloid brain imaging, 3 were excluded because of incomplete language evaluations, 5 for absence of significant aphasia, and 12 for presenting with significant initial symptoms outside of the language domain, leaving a cohort of 89 patients with PPA. Main Outcomes and Measures:Clinical, cognitive, neuroimaging, and pathology results. Results:Twenty-eight cases were classified as imaging-supported semantic variant PPA (11 women [39.3%]; mean [SD] age, 64 [7] years), 31 nonfluent/agrammatic variant PPA (22 women [71.0%]; mean [SD] age, 68 [7] years), 26 logopenic variant PPA (17 women [65.4%]; mean [SD] age, 63 [8] years), and 4 mixed PPA cases. Twenty-four of 28 patients with semantic variant PPA (86%) and 28 of 31 patients with nonfluent/agrammatic variant PPA (90%) had negative amyloid PET scan results, while 25 of 26 patients with logopenic variant PPA (96%) and 3 of 4 mixed PPA cases (75%) had positive scan results. The amyloid positive semantic variant PPA and nonfluent/agrammatic variant PPA cases with available autopsy data (2 of 4 and 2 of 3, respectively) all had a primary frontotemporal lobar degeneration and secondary Alzheimer disease pathologic diagnoses, whereas autopsy of 2 patients with amyloid PET-positive logopenic variant PPA confirmed Alzheimer disease. One mixed PPA patient with a negative amyloid PET scan had Pick disease at autopsy. Conclusions and Relevance:Primary progressive aphasia variant diagnosis according to the current classification scheme is associated with Alzheimer disease biomarker status, with the logopenic variant being associated with carbon 11-labeled Pittsburgh Compound-B positivity in more than 95% of cases. Furthermore, in the presence of a clinical syndrome highly predictive of frontotemporal lobar degeneration pathology, biomarker positivity for Alzheimer disease may be associated more with mixed pathology rather than primary Alzheimer disease.
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Keyword:
Aged; Amyloid; Aniline Compounds; Aphasia; Brain; Ethylene Glycols; Female; Humans; Imaging; Longitudinal Studies; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; Positron-Emission Tomography; Primary Progressive; Retrospective Studies; Severity of Illness Index; Thiazoles; Three-Dimensional
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URL: https://escholarship.org/uc/item/1hm128x5
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Rates of Amyloid Imaging Positivity in Patients With Primary Progressive Aphasia.
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In: JAMA neurology, vol 75, iss 3 (2018)
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32 |
Behavior of hyperreflective foci in non-infectious uveitic macular edema, a 12-month follow-up prospective study
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Diagnostic utility of FDG-PET in the differential diagnosis between different forms of primary progressive aphasia
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In: ISSN: 1619-7070 ; European Journal of Nuclear Medicine and Molecular Imaging, Vol. 45, No 9 (2018) pp. 1526-1533 (2018)
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Hemodynamics of speech production: An fNIRS investigation of children who stutter
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Hemodynamics of speech production: an fNIRS investigation of children who stutter
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Hippocampal activation is associated with longitudinal amyloid accumulation and cognitive decline.
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REPORT ABOUT THE 28TH INTERNATIONAL CONGRESS OF PAPYROLOGY (BARCELONA, 2016)
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In: Lexicon Philosophicum: International Journal for the History of Texts and Ideas; Nr. 5 (2017): Lexicon Philosophicum ; Lexicon Philosophicum: International Journal for the History of Texts and Ideas; No. 5 (2017): Lexicon Philosophicum ; Lexicon Philosophicum: International Journal for the History of Texts and Ideas; Núm. 5 (2017): Lexicon Philosophicum ; Lexicon Philosophicum: International Journal for the History of Texts and Ideas; N. 5 (2017): Lexicon Philosophicum ; 2283-7833 (2017)
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Improving the clinical applicability of electrophysiological assessments and cochlear imaging in adult cochlear implant patients
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Nonâ ionizing realâ time ultrasonography in implant and oral surgery: A feasibility study
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40 |
Spectral Domain Optical Coherence Tomography: An In Vivo Imaging Protocol for Assessing Retinal Morphology in Adult Zebrafish
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In: Zebrafish (2017) (In press). (2017)
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