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More Than Smell-COVID-19 Is Associated With Severe Impairment of Smell, Taste, and Chemesthesis.
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Parma, Valentina; Ohla, Kathrin; Veldhuizen, Maria G; Niv, Masha Y; Kelly, Christine E; Bakke, Alyssa J; Cooper, Keiland W; Bouysset, Cédric; Pirastu, Nicola; Dibattista, Michele; Kaur, Rishemjit; Liuzza, Marco Tullio; Pepino, Marta Y; Schöpf, Veronika; Pereda-Loth, Veronica; Olsson, Shannon B; Gerkin, Richard C; Rohlfs Domínguez, Paloma; Albayay, Javier; Farruggia, Michael C; Bhutani, Surabhi; Fjaeldstad, Alexander W; Kumar, Ritesh; Menini, Anna; Bensafi, Moustafa; Sandell, Mari; Konstantinidis, Iordanis; Di Pizio, Antonella; Genovese, Federica; Öztürk, Lina; Thomas-Danguin, Thierry; Frasnelli, Johannes; Boesveldt, Sanne; Saatci, Özlem; Saraiva, Luis R; Lin, Cailu; Golebiowski, Jérôme; Hwang, Liang-Dar; Ozdener, Mehmet Hakan; Guàrdia, Maria Dolors; Laudamiel, Christophe; Ritchie, Marina; Havlícek, Jan; Pierron, Denis; Roura, Eugeni; Navarro, Marta; Nolden, Alissa A; Lim, Juyun; Whitcroft, Katherine L; Colquitt, Lauren R; Ferdenzi, Camille; Brindha, Evelyn V; Altundag, Aytug; Macchi, Alberto; Nunez-Parra, Alexia; Patel, Zara M; Fiorucci, Sébastien; Philpott, Carl M; Smith, Barry C; Lundström, Johan N; Mucignat, Carla; Parker, Jane K; van den Brink, Mirjam; Schmuker, Michael; Fischmeister, Florian Ph S; Heinbockel, Thomas; Shields, Vonnie DC; Faraji, Farhoud; Santamaría, Enrique; Fredborg, William EA; Morini, Gabriella; Olofsson, Jonas K; Jalessi, Maryam; Karni, Noam; D'Errico, Anna; Alizadeh, Rafieh; Pellegrino, Robert; Meyer, Pablo; Huart, Caroline; Chen, Ben; Soler, Graciela M; Alwashahi, Mohammed K; Welge-Lüssen, Antje; Freiherr, Jessica; de Groot, Jasper HB; Klein, Hadar; Okamoto, Masako; Singh, Preet Bano; Hsieh, Julien W; GCCR Group Author; Reed, Danielle R; Hummel, Thomas; Munger, Steven D; Hayes, John E
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In: Chemical senses, vol 45, iss 7 (2020)
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Abstract:
Recent anecdotal and scientific reports have provided evidence of a link between COVID-19 and chemosensory impairments, such as anosmia. However, these reports have downplayed or failed to distinguish potential effects on taste, ignored chemesthesis, and generally lacked quantitative measurements. Here, we report the development, implementation, and initial results of a multilingual, international questionnaire to assess self-reported quantity and quality of perception in 3 distinct chemosensory modalities (smell, taste, and chemesthesis) before and during COVID-19. In the first 11 days after questionnaire launch, 4039 participants (2913 women, 1118 men, and 8 others, aged 19-79) reported a COVID-19 diagnosis either via laboratory tests or clinical assessment. Importantly, smell, taste, and chemesthetic function were each significantly reduced compared to their status before the disease. Difference scores (maximum possible change ±100) revealed a mean reduction of smell (-79.7 ± 28.7, mean ± standard deviation), taste (-69.0 ± 32.6), and chemesthetic (-37.3 ± 36.2) function during COVID-19. Qualitative changes in olfactory ability (parosmia and phantosmia) were relatively rare and correlated with smell loss. Importantly, perceived nasal obstruction did not account for smell loss. Furthermore, chemosensory impairments were similar between participants in the laboratory test and clinical assessment groups. These results show that COVID-19-associated chemosensory impairment is not limited to smell but also affects taste and chemesthesis. The multimodal impact of COVID-19 and the lack of perceived nasal obstruction suggest that severe acute respiratory syndrome coronavirus strain 2 (SARS-CoV-2) infection may disrupt sensory-neural mechanisms.
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Keyword:
Adult; Aged; Betacoronavirus; Biological Sciences; Coronavirus Infections; Female; GCCR Group Author; head and neck surgery; Humans; Male; Middle Aged; Neurology & Neurosurgery; olfaction; Olfaction Disorders; Pandemics; Pneumonia; Self Report; Smell; somatosensation; Somatosensory Disorders; Surveys and Questionnaires; Taste; Taste Disorders; Viral; Young Adult
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URL: https://escholarship.org/uc/item/76p5k1rx
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More than smell. COVID-19 is associated with severe impairment of smell, taste, and chemesthesis
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In: ISSN: 0379-864X ; EISSN: 1464-3553 ; Chemical Senses ; https://hal.inrae.fr/hal-02911030 ; Chemical Senses, Oxford University Press (OUP), 2020, 45 (7), pp.609-622. ⟨10.1093/chemse/bjaa041⟩ ; https://academic.oup.com/chemse/article/doi/10.1093/chemse/bjaa041/5860460 (2020)
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More Than Smell-COVID-19 Is Associated With Severe Impairment of Smell, Taste, and Chemesthesis
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More than smell – COVID-19 is associated with severe impairment of smell, taste, and chemesthesis
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In: Chem Senses (2020)
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More than smell - COVID-19 is associated with severe impairment of smell, taste, and chemesthesis
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Learning to name smells increases activity in heteromodal semantic areas
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In: ISSN: 1065-9471 ; EISSN: 1097-0193 ; Human Brain Mapping ; https://hal.archives-ouvertes.fr/hal-02343694 ; Human Brain Mapping, Wiley, 2017, 38 (12), pp.5958-5969. ⟨10.1002/hbm.23801⟩ (2017)
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Hedonic appreciation and verbal description of pleasant and unpleasant odors in untrained, trainee cooks, flavorists and perfumers
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In: Frontiers in Cognitive Science ; https://halshs.archives-ouvertes.fr/halshs-00997899 ; Frontiers in Cognitive Science, Frontiers Media S.A, 2014, http://www.frontiersin.org/Journal/10.3389/fpsyg.2014.00012/full (2014)
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Mental Imaging in Professional perfumers, cooks and musicians: linguistic and EEG studies
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In: International Symposium on Olfaction and Taste (ISOT/ECRO) ; https://halshs.archives-ouvertes.fr/halshs-00998112 ; International Symposium on Olfaction and Taste (ISOT/ECRO), 2012, Stockholm, Sweden (2012)
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Mental Imaging in Professional perfumers, cooks and musicians: linguistic and EEG studies
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In: International Symposium on Olfaction and Taste (ISOT/ECRO) ; https://halshs.archives-ouvertes.fr/halshs-00779179 ; International Symposium on Olfaction and Taste (ISOT/ECRO), Jun 2012, Stockholm, Sweden (2012)
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Imagination et création en cuisine : analyse du discours de cuisiniers français et marocains
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In: Colloque International Le Manger et le Dire. Pour une approche du discours culinaire et gastronomique ; https://halshs.archives-ouvertes.fr/halshs-00779200 ; Colloque International Le Manger et le Dire. Pour une approche du discours culinaire et gastronomique, Sep 2012, Bruxelles, Belgique (2012)
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L'imagination des créateurs en cuisine, parfumerie et musique : analyse du discours et du fonctionnement cérébral
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In: La création : acteurs, objets, contextes ; https://halshs.archives-ouvertes.fr/halshs-00745379 ; La création : acteurs, objets, contextes, Oct 2012, France (2012)
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Ontogeny of Odor Liking during Childhood and Its Relation to Language Development
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In: ISSN: 0379-864X ; EISSN: 1464-3553 ; Chemical Senses ; https://halshs.archives-ouvertes.fr/halshs-00778619 ; Chemical Senses, Oxford University Press (OUP), 2011, 36 (1), pp.83-91. ⟨10.1093/chemse/bjq101⟩ (2011)
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Imagination and creation in cooks and perfumers : a linguistic survey
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In: 9th Pangborn Sensory Science Symposium ; https://halshs.archives-ouvertes.fr/halshs-00745386 ; 9th Pangborn Sensory Science Symposium, Sep 2011, Toronto, Canada (2011)
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Ontogeny of Odor Liking during Childhood and Its Relation to Language Development
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The effect of early experience on odor perception in humans: Psychological and physiological correlates
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In: ISSN: 0166-4328 ; EISSN: 1872-7549 ; Behavioural Brain Research ; https://halshs.archives-ouvertes.fr/hal-02343726 ; Behavioural Brain Research, Elsevier, 2010, 2 (2), pp.458-465. ⟨10.1016/j.bbr.2009.12.011⟩ (2010)
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Semantic knowledge influences prewired hedonic responses to odors
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In: ISSN: 1932-6203 ; EISSN: 1932-6203 ; PLoS ONE ; https://halshs.archives-ouvertes.fr/hal-02343722 ; PLoS ONE, Public Library of Science, 2010, 5 (11), ⟨10.1371/journal.pone.0013878⟩ (2010)
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Olfactory nuisance and its impact on quality of life: discourses of residents in a crisis situation
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In: Senses and the City. An Interdisciplinary View of Urban Sensescapes ; https://halshs.archives-ouvertes.fr/halshs-00600013 ; Senses and the City. An Interdisciplinary View of Urban Sensescapes, Lit Verlag, 2010 (2010)
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Ontogeny of Odor Liking during Childhood and Its Relation to Language Development
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Quand une activité écologique est à la source de nuisances. Les revendications environnementales et éthiques des riverains
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In: Colloque Discours écologistes ; https://halshs.archives-ouvertes.fr/halshs-00600025 ; Colloque Discours écologistes, Sep 2009, Paris, France (2009)
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Longitudinal study of olfactory preferences during chilhood
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In: Longitudinal study of olfactory preferences during chilhood ; AChemS (Association for Chemoreception Sciences), 31st Annual Meeting, Hyatt Sarasota, Sarasota, 22-26 avril 2009 ; https://hal.archives-ouvertes.fr/hal-03071947 ; AChemS (Association for Chemoreception Sciences), 31st Annual Meeting, Hyatt Sarasota, Sarasota, 22-26 avril 2009, 2009, Hyatt Sarasota, United States (2009)
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