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1
Mental Health and Social Development Effects of the Abecedarian Approach ; International Journal of Environmental Research and Public Health
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2
Randomized Manipulation of Early Cognitive Experience Impacts Adult Brain Structure ; Journal of Cognitive Neuroscience
Farah, Martha J.; Sternberg, Saul; Nichols, Thomas A.. - : Massachusetts Institute of Technology, 2021
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3
Protein Translation in the Nucleus Accumbens Is Dysregulated during Cocaine Withdrawal and Required for Expression of Incubation of Cocaine Craving
Abstract: Exposure to drug-associated cues can induce drug craving and relapse in abstinent addicts. Cue-induced craving that progressively intensifies (“incubates”) during withdrawal from cocaine has been observed in both rats and humans. Building on recent evidence that aberrant protein translation underlies incubation-related adaptations in the NAc, we used male rats to test the hypothesis that translation is dysregulated during cocaine withdrawal and/or when rats express incubated cocaine craving. We found that intra-NAc infusion of anisomycin, a general protein translation inhibitor, or rapamycin, an inhibitor of mammalian target of rapamycin, reduced the expression of incubated cocaine craving, consistent with previous results showing that inhibition of translation in slices normalized the adaptations that maintain incubation. We then examined signaling pathways involved in protein translation using NAc synaptoneurosomes prepared after >47 d of withdrawal from cocaine or saline self-administration, or after withdrawal plus a cue-induced seeking test. The most robust changes were observed following seeking tests. Most notably, we found that eukaryotic elongation factor 2 (eEF2) and eukaryotic initiation factor 2α (eIF2α) are dephosphorylated when cocaine rats undergo a cue-induced seeking test; both effects are consistent with increased translation during the test. Blocking eIF2α dephosphorylation and thereby restoring its inhibitory influence on translation, via intra-NAc injection of Sal003 just before the test, substantially reduced cocaine seeking. These results are consistent with dysregulation of protein translation in the NAc during cocaine withdrawal, enabling cocaine cues to elicit an aberrant increase in translation that is required for the expression of incubated cocaine craving.
Keyword: Research Articles
URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852654/
http://www.ncbi.nlm.nih.gov/pubmed/29431650
https://doi.org/10.1523/JNEUROSCI.2412-17.2018
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4
Withdrawal from cocaine self-administration alters the regulation of protein translation in the nucleus accumbens
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5
The Role of Contingency and Ostensive Cues on Infants' Cognitively Demanding Word-Object Learning
Mills-Smith, Laura A.. - : Virginia Tech, 2016
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6
An Outbreak of Salmonella Typhimurium 108/170 at a Privately Catered Barbeque at a Sydney Sports Club
In: Foodborne Pathogens and Disease (2015)
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7
An Outbreak of Salmonella Typhimurium 108/170 at a Privately Catered Barbeque at a Sydney Sports Club
In: Foodborne Pathogens and Disease (2015)
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8
Language and communication in mathematics education: an overview of research in the field
In: ZDM , 46 (6) pp. 843-853. (2014) (2014)
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9
"Let me tell you the point": how speakers with aphasia assign prominence to information in narratives
In: Aphasiology. - London [u.a.] : Routledge, Taylor & Francis Group 24 (2010) 6-8, 697-708
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OLC Linguistik
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10
Cultural traditions and the evolutionary advantages of noninnovation
In: Innovation in cultural systems (Cambridge, Mass., 2010), p. 161-174
MPI für Psycholinguistik
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11
Yes, but it was never just about the science
In: Behavioral and brain sciences. - New York, NY [u.a.] : Cambridge Univ. Press 25 (2002) 4, 523
OLC Linguistik
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12
A natural history of rape : biological bases of sexual coercion electronic resource
Thornhill, Randy; Palmer, Craig T.. - Cambridge, Mass. : MIT Press, 2000, 2000
MPI für Psycholinguistik
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13
Language skills of children with different preschool experiences
In: Journal of speech and hearing research. - Rockville, Md. : American Speech-Language-Hearing Association 32 (1989) 4, 773-786
BLLDB
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14
Creating social environments to facilitate language development
Ramey, Craig T. (Mitarb.); Sparling, Joseph J. (Mitarb.); Wasik, Barbara H. (Mitarb.)...
In: Early language. - Baltimore, Md. : Univ. Park Press (1981), 445-586
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15
Structural aspects of maternal speech to infants reared in poverty
In: Child development. - Malden, Ma. [u.a.] : Blackwell 51 (1980) 4, 1280-1284
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16
Critiquing Students ’ Writing: Providing Effective Feedback
In: http://www.ialsnet.org/documents/ntl2007/CraigSmithOutline.pdf
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17
Child Health Bureau of the Public Health Service, the Administration on Children, Youth
In: http://www.psy.cmu.edu/~siegler/423-ramey04.pdf
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