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Mental Health and Social Development Effects of the Abecedarian Approach ; International Journal of Environmental Research and Public Health
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Randomized Manipulation of Early Cognitive Experience Impacts Adult Brain Structure ; Journal of Cognitive Neuroscience
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Protein Translation in the Nucleus Accumbens Is Dysregulated during Cocaine Withdrawal and Required for Expression of Incubation of Cocaine Craving
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Abstract:
Exposure to drug-associated cues can induce drug craving and relapse in abstinent addicts. Cue-induced craving that progressively intensifies (“incubates”) during withdrawal from cocaine has been observed in both rats and humans. Building on recent evidence that aberrant protein translation underlies incubation-related adaptations in the NAc, we used male rats to test the hypothesis that translation is dysregulated during cocaine withdrawal and/or when rats express incubated cocaine craving. We found that intra-NAc infusion of anisomycin, a general protein translation inhibitor, or rapamycin, an inhibitor of mammalian target of rapamycin, reduced the expression of incubated cocaine craving, consistent with previous results showing that inhibition of translation in slices normalized the adaptations that maintain incubation. We then examined signaling pathways involved in protein translation using NAc synaptoneurosomes prepared after >47 d of withdrawal from cocaine or saline self-administration, or after withdrawal plus a cue-induced seeking test. The most robust changes were observed following seeking tests. Most notably, we found that eukaryotic elongation factor 2 (eEF2) and eukaryotic initiation factor 2α (eIF2α) are dephosphorylated when cocaine rats undergo a cue-induced seeking test; both effects are consistent with increased translation during the test. Blocking eIF2α dephosphorylation and thereby restoring its inhibitory influence on translation, via intra-NAc injection of Sal003 just before the test, substantially reduced cocaine seeking. These results are consistent with dysregulation of protein translation in the NAc during cocaine withdrawal, enabling cocaine cues to elicit an aberrant increase in translation that is required for the expression of incubated cocaine craving.
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Research Articles
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URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852654/ http://www.ncbi.nlm.nih.gov/pubmed/29431650 https://doi.org/10.1523/JNEUROSCI.2412-17.2018
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Withdrawal from cocaine self-administration alters the regulation of protein translation in the nucleus accumbens
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The Role of Contingency and Ostensive Cues on Infants' Cognitively Demanding Word-Object Learning
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An Outbreak of Salmonella Typhimurium 108/170 at a Privately Catered Barbeque at a Sydney Sports Club
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In: Foodborne Pathogens and Disease (2015)
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An Outbreak of Salmonella Typhimurium 108/170 at a Privately Catered Barbeque at a Sydney Sports Club
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In: Foodborne Pathogens and Disease (2015)
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Language and communication in mathematics education: an overview of research in the field
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In: ZDM , 46 (6) pp. 843-853. (2014) (2014)
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Critiquing Students ’ Writing: Providing Effective Feedback
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In: http://www.ialsnet.org/documents/ntl2007/CraigSmithOutline.pdf
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Child Health Bureau of the Public Health Service, the Administration on Children, Youth
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In: http://www.psy.cmu.edu/~siegler/423-ramey04.pdf
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