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Label definitions augmented interaction model for legal charge prediction
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In: https://link.springer.com/book/10.1007/978-3-030-72113-8 (2021)
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DNA Methylation Biomarkers of IQ Reduction are Associated with Long-term Lead Exposure in School Aged Children in Southern China
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Wan, C.; Pan, S.; Lin, L.; Li, J.; Dong, G.; Jones, K.C.; Liu, F.; Li, D.; Liu, J.; Yu, Z.; Zhang, G.; Ma, H.. - 2021
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Abstract:
Although lead associated with intelligence decline in children has long been reported, studies combining intelligence determination, molecular mechanisms exploration, and biomarker screen are quite rare. In this study, based on 333 children aged 9-11, we determined the role of DNA methylation (DNAm) in the relationship of lead exposure with children's intelligence. DNAm was measured from children's blood DNA specimens, and mediation analysis was performed to identify DNAm biomarkers mediating the lead-intelligence relationship. We identified forty-three differentially methylated regions (DMRs), and two fragments (FAM50B1 and PTCHD3) significantly mediated the lead-intelligence relationship, with contribution rates of 30.36% (p = 0.010) and 60.36% (p <0.001), respectively. In addition, blood lead levels (BLLs) lower than 100 μg/L still adversely affected children's IQs and DNAm of the two fragments. Our data suggests that DNAm mediates lead-associated cognitive delay in children and blood lead reference value for school-aged children (100 μg/L) should be revised, and the candidate biomarkers can be used in related neurological diseases in future.
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URL: https://eprints.lancs.ac.uk/id/eprint/151749/1/ENVPOL_D_20_02687_MS.pdf https://eprints.lancs.ac.uk/id/eprint/151749/ https://doi.org/10.1021/acs.est.0c01696
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The trans-ancestral genomic architecture of glycemic traits.
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The trans-ancestral genomic architecture of glycemic traits.
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In: Nature genetics, vol. 53, no. 6, pp. 840-860 (2021)
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Are the protective benefits of vitamin D in neurodegenerative disease dependent on route of administration? A systematic review
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In: https://www-tandfonline-com.proxy.library.adelaide.edu.au/doi/full/10.1080/1028415X.2018.1493807 (2020)
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Prescribing competency assessment for Canadian medical students: a pilot evaluation
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Native-speakerism in ELT: A case study of English language education in China
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The Next Frontier in Communication and the ECLIPPSE Study: Bridging the Linguistic Divide in Secure Messaging
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In: Schillinger, D; McNamara, D; Crossley, S; Lyles, C; Moffet, HH; Sarkar, U; et al.(2017). The Next Frontier in Communication and the ECLIPPSE Study: Bridging the Linguistic Divide in Secure Messaging. JOURNAL OF DIABETES RESEARCH. doi:10.1155/2017/1348242. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/0384j5vf (2017)
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A comparative study of students' strategy use in reading texts for the IELTS test and those for academic study
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Evaluation of statistical text normalisation techniques for Twitter
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Evaluation of statistical text normalisation techniques for Twitter
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Evaluation of statistical text normalisation techniques for Twitter
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How does studying abroad change Chinese students' choice of reading strategies?
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Liu, J.. - : University of Toronto Press, 2016
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Methods for conducting systematic reviews of risk factors in low- and middle-income countries
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Social touch gesture recognition using random forest and boosting on distinct feature sets
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Reading transition in Chinese international students: through the lens of activity system theory
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Physical activity during pregnancy and language development in the offspring
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A statistical study on ELF-whistlers/emissions and M ≥ 5.0 earthquakes in Taiwan
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