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What Language Disorders Reveal About the Mechanisms of Morphological Processing
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In: Front Psychol (2021)
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Thematic Integration Impairments in Primary Progressive Aphasia: Evidence From Eye-Tracking
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In: Front Hum Neurosci (2021)
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APOE is a correlate of phenotypic heterogeneity in Alzheimer disease in a national cohort
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In: Neurology (2020)
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Familial language network vulnerability in primary progressive aphasia
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In: Neurology (2020)
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Differential neurocognitive network perturbation in amnestic and aphasic Alzheimer disease
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Perturbations of Language Network Connectivity in Primary Progressive Aphasia
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In: Cortex (2019)
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Word comprehension in temporal cortex and Wernicke area: A PPA perspective
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Mesulam, M.-Marsel; Rader, Benjamin M.; Sridhar, Jaiashre; Nelson, Matthew J.; Hyun, Jungmoon; Rademaker, Alfred; Geula, Changiz; Bigio, Eileen H.; Thompson, Cynthia K.; Gefen, Tamar D.; Weintraub, Sandra; Rogalski, Emily J.. - : Lippincott Williams & Wilkins, 2019
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Abstract:
OBJECTIVE: To explore atrophy–deficit correlations of word comprehension and repetition in temporoparietal cortices encompassing the Wernicke area, based on patients with primary progressive aphasia (PPA). METHODS: Cortical thickness in regions within and outside the classical Wernicke area, measured by FreeSurfer, was correlated with repetition and single word comprehension scores in 73 right-handed patients at mild to moderate stages of PPA. RESULTS: Atrophy in the Wernicke area was correlated with repetition (r = 0.42, p = 0.001) but not single word comprehension (r = −0.072, p = 0.553). Correlations with word comprehension were confined to more anterior parts of the temporal lobe, especially its anterior third (r = 0.60, p < 0.001). A single case with postmortem autopsy illustrated preservation of word comprehension but not repetition 6 months prior to death despite nearly 50% loss of cortical volume and severe neurofibrillary degeneration in core components of the Wernicke area. CONCLUSIONS: Temporoparietal cortices containing the Wernicke area are critical for language repetition. Contrary to the formulations of classic aphasiology, their role in word and sentence comprehension is ancillary rather than critical. Thus, the Wernicke area is not sufficient to sustain word comprehension if the anterior temporal lobe is damaged. Traditional models of the role of the Wernicke area in comprehension are based almost entirely on patients with cerebrovascular lesions. Such lesions also cause deep white matter destruction and acute network diaschisis, whereas progressive neurodegenerative diseases associated with PPA do not. Conceptualizations of the Wernicke area that appear to conflict, therefore, can be reconciled by considering the hodologic and physiologic differences of the underlying lesions.
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Keyword:
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URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340389/ http://www.ncbi.nlm.nih.gov/pubmed/30578374 https://doi.org/10.1212/WNL.0000000000006788
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Verb-argument integration in primary progressive aphasia: Real-time argument access and selection
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In: Neuropsychologia (2019)
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Functional connectivity is reduced in early stage primary progressive aphasia when atrophy is not prominent
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Selective verbal recognition memory impairments are associated with atrophy of the language network in non-semantic variants of primary progressive aphasia
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Communication Bridge: A pilot feasibility study of Internet-based speech–language therapy for individuals with progressive aphasia
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Am I looking at a cat or a dog? Gaze in the semantic variant of primary progressive aphasia is subject to excessive taxonomic capture
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Is in vivo Amyloid Distribution Asymmetric in Primary Progressive Aphasia?
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Asymmetric pathology in primary progressive aphasia with progranulin mutations and TDP inclusions
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Eye Movements as Probes of Lexico-semantic Processing in a Patient with Primary Progressive Aphasia
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Hippocampal subfield surface deformity in non-semantic primary progressive aphasia
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The Wernicke conundrum and the anatomy of language comprehension in primary progressive aphasia
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Asymmetry and heterogeneity of Alzheimer’s and frontotemporal pathology in primary progressive aphasia
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Primary progressive aphasia and the evolving neurology of the language network
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