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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Page: 1 2 3 4 5...11 Hits 1 – 20 of 211 1 Cortical microstructure in primary progressive aphasia: a multicenter study. Illán-Gala, Ignacio; Montal, Victor; Borrego-Écija, Sergi... In: Alzheimer's research & therapy, vol 14, iss 1 (2022) BASE Show details 2 Neuroanatomical correlations of visuospatial processing in primary progressive aphasia Tee, Boon Lead; Watson Pereira, Christa; Lukic, Sladjana... In: Brain Commun (2022) BASE Show details 3 Diminished preparatory physiological responses in frontotemporal lobar degeneration syndromes Chen, Kuan-Hua; Hua, Alice Y.; Toller, Gianina; Lwi, Sandy J.; Otero, Marcela C.; Haase, Claudia M.; Rankin, Katherine P.; Rosen, Howard J.; Miller, Bruce L.; Levenson, Robert W. In: Brain Commun (2022) Abstract: Researchers typically study physiological responses either after stimulus onset or when the emotional valence of an upcoming stimulus is revealed. Yet, participants may also respond when they are told that an emotional stimulus is about to be presented even without knowing its valence. Increased physiological responding during this time may reflect a ‘preparation for action’. The generation of such physiological responses may be supported by frontotemporal regions of the brain that are vulnerable to damage in frontotemporal lobar degeneration. We examined preparatory physiological responses and their structural and functional neural correlate in five frontotemporal lobar degeneration clinical subtypes (behavioural variant frontotemporal dementia, n = 67; semantic variant primary progressive aphasia, n = 35; non-fluent variant primary progressive aphasia, n = 30; corticobasal syndrome, n = 32; progressive supranuclear palsy, n = 30). Comparison groups included patients with Alzheimer’s disease (n = 56) and healthy controls (n = 35). Preparatory responses were quantified as cardiac interbeat interval decreases (i.e. heart rate increases) from baseline to an ‘instruction period’, during which participants were told to watch the upcoming emotional film but not provided the film’s valence. Patients’ behavioural symptoms (apathy and disinhibition) were also evaluated via a caregiver-reported measure. Compared to healthy controls and Alzheimer’s disease, the frontotemporal lobar degeneration group showed significantly smaller preparatory responses. When comparing each frontotemporal lobar degeneration clinical subtype with healthy controls and Alzheimer’s disease, significant group differences emerged for behavioural variant frontotemporal dementia and progressive supranuclear palsy. Behavioural analyses revealed that frontotemporal lobar degeneration patients showed greater disinhibition and apathy compared to Alzheimer’s disease patients. Further, these group differences in disinhibition (but not apathy) were mediated by patients’ smaller preparatory responses. Voxel-based morphometry and resting-state functional MRI analyses revealed that across patients and healthy controls, smaller preparatory responses were associated with smaller volume and lower functional connectivity in a circuit that included the ventromedial prefrontal cortex and cortical and subcortical regions of the salience network. Diminished preparatory physiological responding in frontotemporal lobar degeneration may reflect a lack of preparation for actions that are appropriate for an upcoming situation, such as approaching or withdrawing from emotional stimuli. The ventromedial prefrontal cortex and salience network are critical for evaluating stimuli, thinking about the future, triggering peripheral physiological responses, and processing and interpreting interoceptive signals. Damage to these circuits in frontotemporal lobar degeneration may impair preparatory responses and help explain often-observed clinical symptoms such as disinhibition in these patients. Keyword: Original Article URL: http://www.ncbi.nlm.nih.gov/pubmed/35441132 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9014451/ https://doi.org/10.1093/braincomms/fcac075 BASE Hide details 4 Facilitators and Barriers to Dementia Assessment and Diagnosis: Perspectives From Dementia Experts Within a Global Health Context Bernstein Sideman, Alissa; Al-Rousan, Tala; Tsoy, Elena... In: Front Neurol (2022) BASE Show details 5 Resting functional connectivity in the semantic appraisal network predicts accuracy of emotion identification. Yang, Winson FZ; Toller, Gianina; Shdo, Suzanne. - : eScholarship, University of California, 2021 BASE Show details 6 Uniform data set language measures for bvFTD and PPA diagnosis and monitoring. Staffaroni, Adam M; Weintraub, Sandra; Rascovsky, Katya... In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021) BASE Show details 7 Social Behavior Observer Checklist: Patterns of Spontaneous Behaviors Differentiate Patients With Neurodegenerative Disease From Healthy Older Adults. Rankin, Katherine P; Toller, Gianina; Gavron, Lauren. - : eScholarship, University of California, 2021 BASE Show details 8 Resting functional connectivity in the semantic appraisal network predicts accuracy of emotion identification. Yang, Winson FZ; Toller, Gianina; Shdo, Suzanne. - : eScholarship, University of California, 2021 BASE Show details 9 What Do We Mean by Behavioral Disinhibition in Frontotemporal Dementia? Magrath Guimet, Nahuel; Miller, Bruce L; Allegri, Ricardo F. - : eScholarship, University of California, 2021 BASE Show details 10 Uniform data set language measures for bvFTD and PPA diagnosis and monitoring. Staffaroni, Adam M; Weintraub, Sandra; Rascovsky, Katya... In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021) BASE Show details 11 What Do We Mean by Behavioral Disinhibition in Frontotemporal Dementia? Magrath Guimet, Nahuel; Miller, Bruce L; Allegri, Ricardo F. - : eScholarship, University of California, 2021 BASE Show details 12 Crossed cerebellar diaschisis on 18 F-FDG PET: Frequency across neurodegenerative syndromes and association with 11 C-PIB and 18 F-Flortaucipir ... Provost, Karine; Joie, Renaud La; Strom, Amelia. - : SAGE Journals, 2021 BASE Show details 13 Crossed cerebellar diaschisis on 18 F-FDG PET: Frequency across neurodegenerative syndromes and association with 11 C-PIB and 18 F-Flortaucipir ... Provost, Karine; Joie, Renaud La; Strom, Amelia. - : SAGE Journals, 2021 BASE Show details 14 Social Behavior Observer Checklist: Patterns of Spontaneous Behaviors Differentiate Patients With Neurodegenerative Disease From Healthy Older Adults Rankin, Katherine P.; Toller, Gianina; Gavron, Lauren... In: Front Neurol (2021) BASE Show details 15 Crossed cerebellar diaschisis on (18)F-FDG PET: Frequency across neurodegenerative syndromes and association with (11)C-PIB and (18)F-Flortaucipir Provost, Karine; La Joie, Renaud; Strom, Amelia... In: J Cereb Blood Flow Metab (2021) BASE Show details 16 Uniform data set language measures for bvFTD and PPA diagnosis and monitoring Staffaroni, Adam M.; Weintraub, Sandra; Rascovsky, Katya... In: Alzheimers Dement (Amst) (2021) BASE Show details 17 Association of APOE4 and Clinical Variability in Alzheimer Disease With the Pattern of Tau- and Amyloid-PET La Joie, Renaud; Visani, Adrienne V.; Lesman-Segev, Orit H.... In: Neurology (2021) BASE Show details 18 Resting functional connectivity in the semantic appraisal network predicts accuracy of emotion identification Yang, Winson F.Z.; Toller, Gianina; Shdo, Suzanne... In: Neuroimage Clin (2021) BASE Show details 19 Comparing two facets of emotion perception across multiple neurodegenerative diseases. Brown, Casey L; Hua, Alice Y; De Coster, Lize... In: Social cognitive and affective neuroscience, vol 15, iss 5 (2020) BASE Show details 20 Amount and delay insensitivity during intertemporal choice in three neurodegenerative diseases reflects dorsomedial prefrontal atrophy. Beagle, Alexander J; Zahir, Ali; Borzello, Mia. - : eScholarship, University of California, 2020 BASE Show details Page: 1 2 3 4 5...11

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