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Divergent patterns of loss of interpersonal warmth in frontotemporal dementia syndromes are predicted by altered intrinsic network connectivity.
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Relationship Turmoil and Emotional Empathy in Frontotemporal Dementia
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In: Alzheimer Dis Assoc Disord (2019)
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Divergent patterns of loss of interpersonal warmth in frontotemporal dementia syndromes are predicted by altered intrinsic network connectivity
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Neuroanatomy of Shared Conversational Laughter in Neurodegenerative Disease.
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In: Frontiers in neurology, vol 9, iss JUN (2018)
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Neuroanatomy of Shared Conversational Laughter in Neurodegenerative Disease.
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In: Frontiers in neurology, vol 9, iss JUN (2018)
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Visuospatial Functioning In The Primary Progressive Aphasias
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A neural network underlying intentional emotional facial expression in neurodegenerative disease.
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Gola, Kelly A; Shany-Ur, Tal; Pressman, Peter; Sulman, Isa; Galeana, Eduardo; Paulsen, Hillary; Nguyen, Lauren; Wu, Teresa; Adhimoolam, Babu; Poorzand, Pardis; Miller, Bruce L; Rankin, Katherine P. - : eScholarship, University of California, 2017
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Abstract:
Intentional facial expression of emotion is critical to healthy social interactions. Patients with neurodegenerative disease, particularly those with right temporal or prefrontal atrophy, show dramatic socioemotional impairment. This was an exploratory study examining the neural and behavioral correlates of intentional facial expression of emotion in neurodegenerative disease patients and healthy controls. One hundred and thirty three participants (45 Alzheimer's disease, 16 behavioral variant frontotemporal dementia, 8 non-fluent primary progressive aphasia, 10 progressive supranuclear palsy, 11 right-temporal frontotemporal dementia, 9 semantic variant primary progressive aphasia patients and 34 healthy controls) were video recorded while imitating static images of emotional faces and producing emotional expressions based on verbal command; the accuracy of their expression was rated by blinded raters. Participants also underwent face-to-face socioemotional testing and informants described participants' typical socioemotional behavior. Patients' performance on emotion expression tasks was correlated with gray matter volume using voxel-based morphometry (VBM) across the entire sample. We found that intentional emotional imitation scores were related to fundamental socioemotional deficits; patients with known socioemotional deficits performed worse than controls on intentional emotion imitation; and intentional emotional expression predicted caregiver ratings of empathy and interpersonal warmth. Whole brain VBMs revealed a rightward cortical atrophy pattern homologous to the left lateralized speech production network was associated with intentional emotional imitation deficits. Results point to a possible neural mechanisms underlying complex socioemotional communication deficits in neurodegenerative disease patients.
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Keyword:
2.1 Biological and endogenous factors; 80 and over; Acquired Cognitive Impairment; Aged; Aging; Alzheimer Disease; Alzheimer's Disease; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Aphasia; Basic Behavioral and Social Science; Behavioral and Social Science; Brain Disorders; Brain Mapping; Caregivers; Clinical Research; Computer-Assisted; Dementia; Emotion; Emotions; Empathy; Facial Expression; Female; Frontotemporal Dementia; Frontotemporal Dementia (FTD); Humans; Image Processing; Intention; Magnetic Resonance Imaging; Male; Mental Health; Middle Aged; Mind and Body; Neurodegenerative; Neurodegenerative Diseases; Neurological; Neuropsychological Tests; Neurosciences; Primary Progressive; Primary Progressive Nonfluent Aphasia; Rare Diseases; Social Behavior; Social functioning
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URL: https://escholarship.org/uc/item/9kp6g3dm
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Emotion detection deficits and changes in personality traits linked to loss of white matter integrity in primary progressive aphasia.
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29 |
A neural network underlying intentional emotional facial expression in neurodegenerative disease.
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Emotion detection deficits and changes in personality traits linked to loss of white matter integrity in primary progressive aphasia.
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Visuospatial Functioning in the Primary Progressive Aphasias
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Deconstructing empathy: Neuroanatomical dissociations between affect sharing and prosocial motivation using a patient lesion model
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Emotion detection deficits and changes in personality traits linked to loss of white matter integrity in primary progressive aphasia
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A neural network underlying intentional emotional facial expression in neurodegenerative disease
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35 |
Increased prevalence of autoimmune disease within C9 and FTD/MND cohorts: Completing the picture.
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In: Neurology(R) neuroimmunology & neuroinflammation, vol 3, iss 6 (2016)
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Increased prevalence of autoimmune disease within C9 and FTD/MND cohorts: Completing the picture.
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In: Neurology(R) neuroimmunology & neuroinflammation, vol 3, iss 6 (2016)
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Reading words and other people: a comparison of exception word, familiar face and affect processing in the left and right temporal variants of primary progressive aphasia
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Impaired Recognition and Regulation of Disgust Is Associated with Distinct but Partially Overlapping Patterns of Decreased Gray Matter Volume in the Ventroanterior Insula.
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In: Biological psychiatry, vol 78, iss 7 (2015)
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Criminal behavior in frontotemporal dementia and Alzheimer disease.
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In: JAMA neurology, vol 72, iss 3 (2015)
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Neural basis of motivational approach and withdrawal behaviors in neurodegenerative disease.
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In: Brain and behavior, vol 5, iss 9 (2015)
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