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Diminished preparatory physiological responses in frontotemporal lobar degeneration syndromes
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In: Brain Commun (2022)
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Resting functional connectivity in the semantic appraisal network predicts accuracy of emotion identification.
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Uniform data set language measures for bvFTD and PPA diagnosis and monitoring.
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In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021)
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Social Behavior Observer Checklist: Patterns of Spontaneous Behaviors Differentiate Patients With Neurodegenerative Disease From Healthy Older Adults.
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Resting functional connectivity in the semantic appraisal network predicts accuracy of emotion identification.
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Yang, Winson FZ; Toller, Gianina; Shdo, Suzanne; Kotz, Sonja A; Brown, Jesse; Seeley, William W; Kramer, Joel H; Miller, Bruce L; Rankin, Katherine P. - : eScholarship, University of California, 2021
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Abstract:
ObjectiveStructural and task-based functional studies associate emotion reading with frontotemporal brain networks, though it remains unclear whether functional connectivity (FC) alone predicts emotion reading ability. The predominantly frontotemporal salience and semantic appraisal (SAN) networks are selectively impacted in neurodegenerative disease syndromes like behavioral-variant frontotemporal dementia (bvFTD) and semantic-variant primary progressive aphasia (svPPA). Accurate emotion identification diminishes in some of these patients, but studies investigating the source of this symptom in patients have predominantly examined structural rather than functional brain changes. Thus, we investigated the impact of altered connectivity on their emotion reading.MethodsOne-hundred-eighty-five participants (26 bvFTD, 21 svPPA, 24 non-fluent variant PPA, 24 progressive supranuclear palsy, 49 Alzheimer's disease, 41 neurologically healthy older controls) underwent task-free fMRI, and completed the Emotion Evaluation subtest of The Awareness of Social Inference Test (TASIT-EET), watching videos and selecting labels for actors' emotions.ResultsAs expected, patients averaged significantly worse on emotion reading, but with wide inter-individual variability. Across all groups, lower mean FC in the SAN, but not other ICNs, predicted worse TASIT-EET performance. Node-pair analysis revealed that emotion identification was predicted by FC between 1) right anterior temporal lobe (RaTL) and right anterior orbitofrontal (OFC), 2) RaTL and right posterior OFC, and 3) left basolateral amygdala and left posterior OFC.ConclusionEmotion reading test performance predicts FC in specific SAN regions mediating socioemotional semantics, personalized evaluations, and salience-driven attention, highlighting the value of emotion testing in clinical and research settings to index neural circuit dysfunction in patients with neurodegeneration and other neurologic disorders.
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Keyword:
2.1 Biological and endogenous factors; Acquired Cognitive Impairment; Aging; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Aphasia; Basic Behavioral and Social Science; Behavioral and Social Science; Brain; Brain Disorders; Clinical Research; Dementia; Emotion reading; Emotions; Frontotemporal Dementia; Frontotemporal Dementia (FTD); Functional connectivity; Humans; Magnetic Resonance Imaging; Neurodegeneration; Neurodegenerative; Neurodegenerative Diseases; Neurological; Neurosciences; Primary Progressive; Right anterior temporal lobe; Semantic appraisal network; Semantics
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URL: https://escholarship.org/uc/item/67m8f14f
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| 6 |
What Do We Mean by Behavioral Disinhibition in Frontotemporal Dementia?
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| 7 |
Uniform data set language measures for bvFTD and PPA diagnosis and monitoring.
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In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021)
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| 8 |
What Do We Mean by Behavioral Disinhibition in Frontotemporal Dementia?
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Social Behavior Observer Checklist: Patterns of Spontaneous Behaviors Differentiate Patients With Neurodegenerative Disease From Healthy Older Adults
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In: Front Neurol (2021)
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| 10 |
Uniform data set language measures for bvFTD and PPA diagnosis and monitoring
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In: Alzheimers Dement (Amst) (2021)
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Resting functional connectivity in the semantic appraisal network predicts accuracy of emotion identification
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In: Neuroimage Clin (2021)
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Depressive Symptom Profiles Predict Specific Neurodegenerative Disease Syndromes in Early Stages.
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Depressive Symptom Profiles Predict Specific Neurodegenerative Disease Syndromes in Early Stages.
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| 14 |
Depressive Symptom Profiles Predict Specific Neurodegenerative Disease Syndromes in Early Stages
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In: Front Neurol (2020)
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Divergent patterns of loss of interpersonal warmth in frontotemporal dementia syndromes are predicted by altered intrinsic network connectivity.
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In: Toller, Gianina; Yang, Winson FZ; Brown, Jesse A; Ranasinghe, Kamalini G; Shdo, Suzanne M; Kramer, Joel H; et al.(2019). Divergent patterns of loss of interpersonal warmth in frontotemporal dementia syndromes are predicted by altered intrinsic network connectivity. NeuroImage. Clinical, 22, 101729. doi:10.1016/j.nicl.2019.101729. UCSF: Retrieved from: http://www.escholarship.org/uc/item/9qm527cr (2019)
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| 16 |
Factors that predict diagnostic stability in neurodegenerative dementia.
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In: Journal of neurology, vol 266, iss 8 (2019)
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| 17 |
Factors that predict diagnostic stability in neurodegenerative dementia.
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In: Journal of neurology, vol 266, iss 8 (2019)
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| 18 |
Relationship Turmoil and Emotional Empathy in Frontotemporal Dementia.
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In: Alzheimer disease and associated disorders, vol 33, iss 3 (2019)
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| 19 |
Divergent patterns of loss of interpersonal warmth in frontotemporal dementia syndromes are predicted by altered intrinsic network connectivity.
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| 20 |
Relationship Turmoil and Emotional Empathy in Frontotemporal Dementia.
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In: Alzheimer disease and associated disorders, vol 33, iss 3 (2019)
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