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Divergent patterns of loss of interpersonal warmth in frontotemporal dementia syndromes are predicted by altered intrinsic network connectivity.
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Relationship Turmoil and Emotional Empathy in Frontotemporal Dementia
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In: Alzheimer Dis Assoc Disord (2019)
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Divergent patterns of loss of interpersonal warmth in frontotemporal dementia syndromes are predicted by altered intrinsic network connectivity
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Neuroanatomy of Shared Conversational Laughter in Neurodegenerative Disease.
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In: Frontiers in neurology, vol 9, iss JUN (2018)
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Abstract:
Perceiving another person's emotional expression often sparks a corresponding signal in the observer. Shared conversational laughter is a familiar example. Prior studies of shared laughter have made use of task-based functional neuroimaging. While these methods offer insight in a controlled setting, the ecological validity of such controlled tasks has limitations. Here, we investigate the neural correlates of shared laughter in patients with one of a variety of neurodegenerative disease syndromes (N = 75), including Alzheimer's disease (AD), behavioral variant frontotemporal dementia (bvFTD), right and left temporal variants of semantic dementia (rtvFTD, svPPA), nonfluent/agrammatic primary progressive aphasia (nfvPPA), corticobasal syndrome (CBS), and progressive supranuclear palsy (PSP). Patients were recorded in a brief unrehearsed conversation with a partner (e.g., a friend or family member). Laughter was manually labeled, and an automated system was used to assess the timing of that laughter relative to the partner's laughter. The probability of each participant with neurodegenerative disease laughing during or shortly after his or her partners' laughter was compared to differences in brain morphology using voxel-based morphometry, thresholded based on cluster size and a permutation method and including age, sex, magnet strength, disease-specific atrophy and total intracranial volumes as covariates. While no significant correlations were found at the critical T value, at a corrected voxelwise threshold of p < 0.005, a cluster in the left posterior cingulate gyrus demonstrated a trend at p = 0.08 (T = 4.54). Exploratory analysis with a voxelwise threshold of p = 0.001 also suggests involvement of the left precuneus (T = 3.91) and right fusiform gyrus (T = 3.86). The precuneus has been previously implicated in the detection of socially complex laughter, and the fusiform gyrus has a well-described role in the recognition and processing of others' emotional cues. This study is limited by a relatively small sample size given the number of covariates. While further investigation is needed, these results support our understanding of the neural underpinnings of shared conversational laughter.
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Keyword:
Acquired Cognitive Impairment; Aging; Alzheimer's Disease; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Brain Disorders; Clinical Research; Clinical Sciences; communication; Dementia; empathy; laughter; Mental Health; neuroanatomy; Neurodegenerative; Neurological; Neurosciences; Psychology; Rare Diseases; voxel-based morphometry
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URL: https://escholarship.org/uc/item/7hr0s5hz
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Neuroanatomy of Shared Conversational Laughter in Neurodegenerative Disease.
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In: Frontiers in neurology, vol 9, iss JUN (2018)
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Visuospatial Functioning In The Primary Progressive Aphasias
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A neural network underlying intentional emotional facial expression in neurodegenerative disease.
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Emotion detection deficits and changes in personality traits linked to loss of white matter integrity in primary progressive aphasia.
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A neural network underlying intentional emotional facial expression in neurodegenerative disease.
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Emotion detection deficits and changes in personality traits linked to loss of white matter integrity in primary progressive aphasia.
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Visuospatial Functioning in the Primary Progressive Aphasias
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Deconstructing empathy: Neuroanatomical dissociations between affect sharing and prosocial motivation using a patient lesion model
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Emotion detection deficits and changes in personality traits linked to loss of white matter integrity in primary progressive aphasia
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A neural network underlying intentional emotional facial expression in neurodegenerative disease
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Increased prevalence of autoimmune disease within C9 and FTD/MND cohorts: Completing the picture.
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In: Neurology(R) neuroimmunology & neuroinflammation, vol 3, iss 6 (2016)
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Increased prevalence of autoimmune disease within C9 and FTD/MND cohorts: Completing the picture.
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In: Neurology(R) neuroimmunology & neuroinflammation, vol 3, iss 6 (2016)
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Reading words and other people: a comparison of exception word, familiar face and affect processing in the left and right temporal variants of primary progressive aphasia
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Impaired Recognition and Regulation of Disgust Is Associated with Distinct but Partially Overlapping Patterns of Decreased Gray Matter Volume in the Ventroanterior Insula.
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In: Biological psychiatry, vol 78, iss 7 (2015)
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Criminal behavior in frontotemporal dementia and Alzheimer disease.
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In: JAMA neurology, vol 72, iss 3 (2015)
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Neural basis of motivational approach and withdrawal behaviors in neurodegenerative disease.
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In: Brain and behavior, vol 5, iss 9 (2015)
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