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Common polygenic risk for ASD and ADHD is associated with childhood linguistic traits within the general population, but with opposite effects
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Genome-wide association analyses of child genotype effects and parent-of-origin effects in specific language impairment
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Characterization of the DYX2 locus on chromosome 6p22 with reading disability, language impairment, and IQ
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Common variation near ROBO2 is associated with expressive vocabulary in infancy
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Common variation near ROBO2 is associated with expressive vocabulary in infancy
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Common variation near ROBO2 is associated with expressive vocabulary in infancy
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St Pourcain, Beate; Cents, Rolieke A. M.; Whitehouse, Andrew J. O.; Haworth, Claire M. A.; Davis, Oliver S. P.; O'Reilly, Paul F.; Roulstone, Susan; Wren, Yvonne; Ang, Qi W.; Velders, Fleur P.; Evans, David M.; Kemp, John P.; Warrington, Nicole M.; Miller, Laura; Timpson, Nicholas J.; Ring, Susan M.; Verhulst, Frank C.; Hofman, Albert; Rivadeneira, Fernando; Meaburn, Emma L.; Price, Thomas S.; Dale, Philip S.; Pillas, Demetris; Yliherva, Anneli; Rodriguez, Alina; Golding, Jean; Jaddoe, Vincent W. V.; Jarvelin, Marjo-Riitta; Plomin, Robert; Pennell, Craig E.; Tiemeier, Henning. - : Nature Publishing Group, 2014
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Abstract:
Twin studies suggest that expressive vocabulary at ~24 months is modestly heritable. However, the genes influencing this early linguistic phenotype are unknown. Here we conduct a genome-wide screen and follow-up study of expressive vocabulary in toddlers of European descent from up to four studies of the EArly Genetics and Lifecourse Epidemiology consortium, analysing an early (15-18 months, 'one-word stage', N=8,889) and a later (24-30 months, 'two-word stage', NTotal=10,819) phase of language acquisition. For the early phase, one single-nucleotide polymorphism (rs7642482) at 3p12.3 near ROBO2, encoding a conserved axon-binding receptor, reaches the genome-wide significance level (P=1.3×10) in the combined sample. This association links language-related common genetic variation in the general population to a potential autism susceptibility locus and a linkage region for dyslexia, speech-sound disorder and reading. The contribution of common genetic influences is, although modest, supported by genome-wide complex trait analysis (meta-GCTA h=0.13, meta-GCTA h =0.14) and in concordance with additional twin analysis (5,733 pairs of European descent, h=0.20).
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Keyword:
1300 Biochemistry; 1600 Chemistry; 3100 Physics and Astronomy; General Biochemistry; General Chemistry; General Physics and Astronomy; Genetics and Molecular Biology
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URL: https://espace.library.uq.edu.au/view/UQ:351771
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Common variation near ROBO2 is associated with expressive vocabulary in infancy
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Associations of Prenatal Nicotine Exposure and the Dopamine Related Genes ANKK1 and DRD2 to Verbal Language
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Associations of Prenatal Nicotine Exposure and the Dopamine Related Genes ANKK1 and DRD2 to Verbal Language
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