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Attitudes and Practices Regarding Research among Romanian Medical Undergraduate Students
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In: International Journal of Environmental Research and Public Health; Volume 19; Issue 3; Pages: 1872 (2022)
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Medical Students’ Personalities: A Critical Factor for Doctor–Patient Communication
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In: International Journal of Environmental Research and Public Health ; Volume 18 ; Issue 17 (2021)
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A Holistic Approach of Personality Traits in Medical Students: An Integrative Review
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In: International Journal of Environmental Research and Public Health; Volume 18; Issue 23; Pages: 12822 (2021)
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The Musical Instruments in the Early Vernacular Translations of the Psalms (2): Collective Research
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In: ISSN: 2601-2200 ; Museikon: A Journal of Religious Art and Culture / Revue d'art et de culture religieuse ; https://hal.archives-ouvertes.fr/hal-03098249 ; Museikon: A Journal of Religious Art and Culture / Revue d'art et de culture religieuse, 2020 (2020)
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The Dual Blockade in the Neoadjuvant Setting of HER-2 Positive Early-Stage Breast Cancer
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Abstract:
Patients with positive Her-2/neu breast cancer and a high risk of recurrence are known to benefit from the addition of the dual blockade of Her-2/neu with Trastuzumab and Pertuzumab to the neoadjuvant chemotherapy, a combination which has been demonstrated to give a higher rate of a complete pathologic response in the breast and in the axilla. The purpose of this review is to outline the efficacy of the dual blockade with Trastuzumab and Pertuzumab in the neoadjuvant treatment of high-risk Her-2 positive breast cancer. Electronic databases (Pubmed, Medline, and Cochrane Database of Systematic Reviews) were searched for English- and German-language studies, which were published in the last ten years. The search has been focused on neoadjuvant clinical trials as well as on the data presented in the abstracts published at the San Antonio Breast Cancer Symposium as well as at the annual meeting of the American Society of Clinical Oncology. The results reported in the published clinical trials demonstrated a higher pathologic complete response rate in breast and lymph nodes after using targeted therapy with two anti-Her-2/neu agents - Trastuzumab and Pertuzumab in combination with neoadjuvant chemotherapy for early-stage Her-2/neu positive breast cancers. The pathologic complete response rate is the most important prognostic marker in Her-2/neu positive tumors, a higher pathologic complete response rate being demonstrated to be associated with a better survival outcome in terms of higher overall survival and disease-free survival rates.
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Keyword:
Review
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URL: https://doi.org/10.25122/jml-2019-0115 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6993292/
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A British Library Fragment from a Homily on the Lament of Mary and the So-Called Gospel of Gamaliel
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In: Aethiopica; Bd. 15 (2012); 53-71 ; Aethiopica; Vol. 15 (2012); 53-71 ; 2194-4024 ; 1430-1938 ; 10.15460/aethiopica.15.1 (2013)
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Basal insulin and cardiovascular and other outcomes in dysglycemia.
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In: New England Journal of Medicine, vol. 367, no. 4, pp. 319-328 (2012)
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n-3 fatty acids and cardiovascular outcomes in patients with dysglycemia.
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In: New England Journal of Medicine, vol. 367, no. 4, pp. 309-318 (2012)
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A Peformant XQuery to SQL Translator
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In: http://silkroute.cs.washington.edu/SilkRouteII_TR.pdf (2006)
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Topological Queries in Spatial Databases
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In: http://www.cs.washington.edu/homes/suciu/files/victor-camera-ready.ps (1996)
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Topological Queries in Spatial Databases
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In: http://www-cse.ucsd.edu/users/vianu/PAPERS/suciu.ps.gz (1996)
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Programming Constructs for Unstructured Data
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In: ftp://ftp.cis.upenn.edu/pub/papers/db-research/unstructured.ps.Z (1995)
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