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Global genetic differentiation of complex traits shaped by natural selection in humans
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Guo, Jing; Wu, Yang; Zhu, Zhihong; Zheng, Zhili; Trzaskowski, Maciej; Zeng, Jian; Robinson, Matthew R.; Visscher, Peter M.; Yang, Jian. - : Nature Publishing Group, 2018
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Abstract:
There are mean differences in complex traits among global human populations. We hypothesize that part of the phenotypic differentiation is due to natural selection. To address this hypothesis, we assess the differentiation in allele frequencies of trait-associated SNPs among African, Eastern Asian, and European populations for ten complex traits using data of large sample size (up to ~405,000). We show that SNPs associated with height ([Formula: see text]), waist-to-hip ratio ([Formula: see text]), and schizophrenia ([Formula: see text]) are significantly more differentiated among populations than matched "control" SNPs, suggesting that these trait-associated SNPs have undergone natural selection. We further find that SNPs associated with height ([Formula: see text]) and schizophrenia ([Formula: see text]) show significantly higher variance in linkage disequilibrium (LD) scores across populations than control SNPs. Our results support the hypothesis that natural selection has shaped the genetic differentiation of complex traits, such as height and schizophrenia, among worldwide populations.
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Keyword:
1300 Biochemistry; 1600 Chemistry; 3100 Physics and Astronomy; African-Americans; Body-Mass Index; Coronary-Heart-Disease; Demographic History; Ethnic-Differences; Genetics and Molecular Biology; Human Genome; Human Height; Missing Heritability; Recent Positive Selection; Visceral Adipose-Tissue
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URL: https://espace.library.uq.edu.au/view/UQ:f7bddff https://espace.library.uq.edu.au/view/UQ:f7bddff/UQf7bddff_OA.pdf
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Details of Genomewide Association Results, Protocol, Statistical Analysis, and Additional References (Harlaar et al., 2014) ...
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Details of Genomewide Association Results, Protocol, Statistical Analysis, and Additional References (Harlaar et al., 2014) ...
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Genome-Wide Association Study of Receptive Language Ability of 12-Year-Olds
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The high heritability of educational achievement reflects many genetically influenced traits, not just intelligence
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Genome-wide association study of receptive language ability of 12-year-olds
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Genome-wide association study of receptive language ability of 12-year-olds
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Intelligence indexes generalist genes for cognitive abilities☆
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DNA Evidence for Strong Genome-Wide Pleiotropy of Cognitive and Learning Abilities
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DNA evidence for strong genome-wide pleiotropy of cognitive and learning abilities
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Intelligence indexes generalist genes for cognitive abilities
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Socioeconomic status (SES) and children's intelligence (IQ): In a uk-representative sample SES moderates the environmental, not genetic, effect on IQ
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Socioeconomic status (SES) and children's intelligence (IQ) : in a UK-representative sample SES moderates the environmental, not genetic, effect on IQ
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Sentence comprehension in competing speech: Dichotic sentence-word priming reveals hemispheric differences in auditory semantic processing
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