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P-hydroxy benzaldehyde facilitates reprogramming of reactive astrocytes into neurons via endogenous transcriptional regulation ...
Li, Xin; Fan, Ruoxi; Xiang, Jianming. - : Taylor & Francis, 2022
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P-hydroxy benzaldehyde facilitates reprogramming of reactive astrocytes into neurons via endogenous transcriptional regulation ...
Abstract: Cerebral ischemia leads to linguistic and motor dysfunction, as the death of neurons in ischemic core is permanent and non-renewable. An innovative avenue is to induce and/or facilitate reprogramming of adjacent astrocytes into neurons to replace the lost neurons and re-establish brain homeostasis. This study aimed to investigate whether the p-hydroxy benzaldehyde (p-HBA), a phenolic compound isolated from Gastrodia elata Blume, could facilitate the reprogramming of oxygen-glucose deprivation/reperfusion (OGD/R)-damaged astrocytes into neurons. The primary parenchymal astrocytes of rat were exposure to OGD and reperfusion with define culture medium. Cells were then incubated with different concentration of p-HBA (1, 10, 100, 400 μM) and collected at desired time point for reprogramming process analysis. OGD/R could elicit endogenous neurogenic program in primary parenchymal astrocytes of rat under define culture condition, and these so-called reactive astrocytes could be reprogrammed into neurons. However, ...
Keyword: 111714 Mental Health; Biochemistry; Cell Biology; Developmental Biology; FOS Biological sciences; FOS Health sciences; Molecular Biology; Neuroscience; Pharmacology; Physiology
URL: https://tandf.figshare.com/articles/dataset/p-hydroxy_benzaldehyde_facilitates_reprogramming_of_reactive_astrocytes_into_neurons_via_endogenous_transcriptional_regulation/19410318
https://dx.doi.org/10.6084/m9.figshare.19410318
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p-hydroxy benzaldehyde facilitates reprogramming of reactive astrocytes into neurons via endogenous transcriptional regulation ...
Li, Xin; Fan, Ruoxi; Xiang, Jianming. - : Taylor & Francis, 2022
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4
Phonological and semantic specialization in 9- to 10-year-old children during auditory word processing ...
Wang, Jin. - : Open Science Framework, 2022
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5
Neural pathways of phonological and semantic processing and its relations to children’s reading skills ...
Wagley, Neelima. - : Open Science Framework, 2022
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6
Detecting structured repetition in child-surrounding speech: Evidence from maximally diverse languages
In: Lester, Nicholas A; Moran, Steven; Küntay, Aylin C; Allen, Shanley E M; Pfeiler, Barbara; Stoll, Sabine (2022). Detecting structured repetition in child-surrounding speech: Evidence from maximally diverse languages. Cognition, 221:104986. (2022)
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7
Developmental changes in neural letter‐selectivity: A 1‐year follow‐up of beginning readers
In: ISSN: 1363-755X ; EISSN: 1467-7687 ; Developmental Science ; https://hal.archives-ouvertes.fr/hal-02931200 ; Developmental Science, Wiley, 2021, 21 (1), pp.e12999. ⟨10.1111/desc.12999⟩ (2021)
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Editorial: Neuro-cognitive Architecture of Numerical Cognition and Its Development
In: ISSN: 1662-5161 ; Frontiers in Human Neuroscience ; https://halshs.archives-ouvertes.fr/halshs-03344079 ; Frontiers in Human Neuroscience, Frontiers, 2021, 15, ⟨10.3389/fnhum.2021.670460⟩ (2021)
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9
Language skill development in children with cochlear implants and the impact of age at switch-on ...
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10
Language skill development in children with cochlear implants and the impact of age at switch-on ...
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11
SANKAT PRADATA AUR JANATA. ...
Tomar, Neetusingh. - : figshare, 2021
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12
SANKAT PRADATA AUR JANATA. ...
Tomar, Neetusingh. - : figshare, 2021
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13
SANKAT PRADATA AUR JANATA. ...
Tomar, Neetusingh. - : figshare, 2021
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14
SANKAT PRADATA AUR JANATA. ...
Tomar, Neetusingh. - : figshare, 2021
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15
Meta-Analysis Data from 'A Role for Visual Memory in Vocabulary Development: A Systematic Review and Meta-Analysis' ...
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16
Supplementary Videos ...
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Supplementary Videos ...
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18
Can Children use Numerical Reasoning to Compare Odds in Games? ...
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Can Children use Numerical Reasoning to Compare Odds in Games? ...
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20
Does group intervention make a difference for the speech sound development of Dutch pre-school children with Developmental Language Disorder? ...
Ottow-Henning, Esther; Keij, Brigitta. - : Taylor & Francis, 2021
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