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Eliciting Requirements for a Diabetes Self-Management Application for Underserved Populations: A Multi-Stakeholder Analysis
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In: International Journal of Environmental Research and Public Health; Volume 19; Issue 1; Pages: 127 (2021)
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Adaptation and psychometric validation of Diabetes Health Profile (DHP-18) in patients with type 2 diabetes in Quito, Ecuador : a cross-sectional study
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Diabetes Apps: Information about COVID-19 and Risk Factors?
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In: J Endocr Soc (2021)
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Dysphonia, arterial hypertension, diabetes mellitus, thyroid diseases, and noise complaints as probable factors associated with hearing loss among teachers
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In: Revista CEFAC, Vol 23, Iss 2 (2021) (2021)
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Effectiveness of Culturally Tailored Interventions for Hispanic Adults with Type 2 Diabetes Mellitus
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Association between diabetes and vestibular dysfunction: an integrative review
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In: Revista CEFAC, Vol 22, Iss 1 (2020) (2020)
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Partial remission and early stages of pediatric type 1 diabetes display immunoregulatory changes. A pilot study
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MON-162 Hepatic DNA Damage Induced by ENDS Is Associated with Decreased Levels of NAD+
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SAT-122 A Mobile App to Decrease Risk Factors for Diabetes in Women with Recent GDM
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Language-concordant automated telephone queries to assess medication adherence in a diverse population: a cross-sectional analysis of convergent validity with pharmacy claims.
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In: BMC health services research, vol 18, iss 1 (2018)
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Disparities in Diabetes Care Quality by English Language Preference in Community Health Centers.
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In: Health services research, vol 53, iss 1 (2018)
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Associations of maternal vitamin D deficiency with pregnancy and neonatal complications in developing countries: a systematic review
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Comorbidities, complications and mortality in people of South Asian ethnicity with type 1 diabetes compared with other ethnic groups: a systematic review
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Technology-enhanced consultations in diabetes, cancer, and heart failure: protocol for the qualitative analysis of remote consultations (QuARC) project
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The Next Frontier in Communication and the ECLIPPSE Study: Bridging the Linguistic Divide in Secure Messaging.
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The Next Frontier in Communication and the ECLIPPSE Study: Bridging the Linguistic Divide in Secure Messaging.
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APRN-Led Culturally Tailored Diabetes Self-Management Education (DSME) for Spanish-Speaking Hispanic Americans (SSHAs) ...
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Diabetes Mellitus and the Effects on Auditory Processing
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In: ETSU Faculty Works (2017)
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Health effects of non-nutritive sweeteners: analysis of the research landscape
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In: Nutrition journal. 16 (2017), 55, DOI 10.1186/s12937-017-0278-x, issn: 1475-2891 (2017)
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Zinc status of those with type 2 diabetes compared to a healthy population: A systematic review.
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Abstract:
Background: Zinc is vital to many physiological and biological functions in the human body. It is essential to many structural, catalytic and regulatory functions including the formation and stabilisation of insulin complexes. In addition to the link between zinc and insulin, having optimum zinc status can contribute to well-controlled diabetes. The main effect of type 2 diabetes mellitus (T2DM) on zinc homeostasis is hypozincaemia, primarily due to hyperzincuria and to lesser extent decreased gastrointestinal reabsorption of zinc. However, the results on this are often contradictory displaying the need for more uniform analysis of the effects T2DM has on zinc status. Objective: The aim of this project was to conduct a systematic review of cross sectional studies, comparing the zinc status of those with T2DM to a healthy population. Methods: This systematic review follows the Cochrane design for systematic reviews. Data sources were English language studies in Ovid MEDLINE (R) 1946 to February 2016, Ovid Embase Classic + Embase 1947 to February 2016, SCOPUS and Web of Science core, with manual searches of in-text citations. Criteria for eligibility of studies included: studies must be cross-sectional investigating zinc status of subjects over the age of 18 years with T2DM in comparison to healthy subjects. Studies must include measures of serum/plasma or blood glucose, HbA1c or a combination and data on zinc status biomarkers (serum, plasma, hair, urine, nails, erythrocytes, zinc-related enzymes and dietary zinc). Results: From the 13,258 studies identified, 29 of these met the eligibility criteria for the current systematic review. These studies came from 16 countries including; England, Pakistan, Iran, China, Nigeria, Turkey, Ghana, Egypt, Israel, Slovakia, Ireland, the USA, India, Austria, Bangladesh and Saudi Arabia. The majority of the studies measured zinc status through serum or plasma, followed by hair zinc and urinary zinc, with the remaining six studies measuring a combination of the afore mentioned biomarkers with the addition of erythrocyte zinc. Of the 26 studies that measured serum/plasma zinc, 21 concluded that those suffering from T2DM have lower zinc status than a healthy population and 17 stated that their results were significant (p<0.05). All studies that measured hair or erythrocyte zinc as a biomarker of zinc status showed that it was lower in those with T2DM. All of the remaining studies that measured urinary zinc status stated that it was higher in those with T2DM. We found a positive correlation with absolute HbA1c and serum/plasma zinc levels, p= 0.002. Conclusion: This systematic review concludes that those with T2DM generally have a lower zinc status than the healthy population. Our study has highlighted that plasma, serum, hair, and erythrocyte zinc biomarkers are generally lower and urinary zinc is higher among those with T2DM, when compared to a healthy population. The central view throughout this review is that those suffering from T2DM are prone to hyperzincuria, which can distort the homeostasis of zinc in the body.
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Keyword:
Diabetes; Nutrition; Review; systematic review; type 2 diabetes mellitus; Zinc; zinc status
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URL: http://hdl.handle.net/10523/7164
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