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Cortical microstructure in primary progressive aphasia: a multicenter study.
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In: Alzheimer's research & therapy, vol 14, iss 1 (2022)
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| 2 |
A Preliminary Report of Network Electroencephalographic Measures in Primary Progressive Apraxia of Speech and Aphasia
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In: Brain Sciences; Volume 12; Issue 3; Pages: 378 (2022)
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Primary and Secondary Progressive Aphasia in Posterior Cortical Atrophy
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In: Life; Volume 12; Issue 5; Pages: 662 (2022)
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| 4 |
Imaging Clinical Subtypes and Associated Brain Networks in Alzheimer’s Disease
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In: Brain Sciences; Volume 12; Issue 2; Pages: 146 (2022)
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A 'Mini Linguistic State Examination' to classify primary progressive aphasia. ...
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| 6 |
A 'Mini Linguistic State Examination' to classify primary progressive aphasia. ...
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Improving the diagnostic accuracy of primary progressive aphasia using cognitive tests
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Foxe, David Gordon. - : The University of Sydney, 2022. : Faculty of Science, School of Psychology, 2022
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Abstract:
Primary progressive aphasias (PPA) are rare younger-onset dementias that primarily affect speech and language functions. Three subtypes of PPA have been identified and are classified based on the presence or absence of core language, imaging, and clinical findings: logopenic (lv-PPA), non-fluent (nfv-PPA) and semantic variant (sv-PPA). Differentiating these variants is important for treatment and planning; however, assessment of the nfv-PPA and lv-PPA variants’ speech and language is often difficult for clinicians with limited expertise. As such, simple language, cognitive, and behavioural tests are needed to aid diagnosis. This thesis comprises five studies that investigates this issue. Chapter 3 showed that, relative to the other PPA variants, lv-PPA is particularly impaired on a simple measure of visuospatial short-term memory, and that this impairment relates to the grey matter intensity decrease of the parietal lobe and surrounding regions. Chapter 4 expanded on these findings using a novel, computerised visuospatial working memory test. Using the cognitive subdomain scores of a cognitive screening tool (ACE-III), Chapter 5 found that the cognitive profiles of the PPA variants were distinct at baseline visit and over time. Crucially, cognitive decline in lv-PPA was more widespread and rapid than in nfv-PPA and sv-PPA. Chapter 6 demonstrated that PPA profiling is enhanced when evaluating the individual items of the ACE-III, and an interactive online ACE-III PPA diagnostic calculator was built for clinicians. Finally, Chapter 7 established that the mood, behaviour, and everyday skills profiles of the PPA variants are distinct at initial presentation and over the disease course. The work within this thesis demonstrates that the evolving cognitive and behavioural profiles of the PPA variants are distinct and extend beyond the primary disorder of language. Accordingly, assessing these skills in clinical practice can improve the diagnostic accuracy of the PPA variants.
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Keyword:
Alzheimer's disease; frontotemporal dementia; neuropsy; primary progressive aphasia
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URL: https://hdl.handle.net/2123/27582
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| 8 |
Neural substrates of verbal repetition deficits in primary progressive aphasia.
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| 9 |
Resting functional connectivity in the semantic appraisal network predicts accuracy of emotion identification.
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| 10 |
Neural dynamics of semantic categorization in semantic variant of primary progressive aphasia.
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| 11 |
Uniform data set language measures for bvFTD and PPA diagnosis and monitoring.
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In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021)
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| 12 |
Resting functional connectivity in the semantic appraisal network predicts accuracy of emotion identification.
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| 13 |
What Do We Mean by Behavioral Disinhibition in Frontotemporal Dementia?
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| 14 |
Uniform data set language measures for bvFTD and PPA diagnosis and monitoring.
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In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021)
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What Do We Mean by Behavioral Disinhibition in Frontotemporal Dementia?
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| 16 |
Primary Progressive Aphasia: Use of Graphical Markers for an Early and Differential Diagnosis
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In: Brain Sciences ; Volume 11 ; Issue 9 (2021)
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| 17 |
Survival in the Three Common Variants of Primary Progressive Aphasia: A Retrospective Study in a Tertiary Memory Clinic
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In: Brain Sciences ; Volume 11 ; Issue 9 (2021)
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| 18 |
Application of Machine Learning to Electroencephalography for the Diagnosis of Primary Progressive Aphasia: A Pilot Study
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In: Brain Sciences ; Volume 11 ; Issue 10 (2021)
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| 19 |
Longitudinal Changes in Cognition, Behaviours, and Functional Abilities in the Three Main Variants of Primary Progressive Aphasia: A Literature Review
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In: Brain Sciences ; Volume 11 ; Issue 9 (2021)
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| 20 |
Verbal Short-Term Memory Disturbance in the Primary Progressive Aphasias: Challenges and Distinctions in a Clinical Setting
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In: Brain Sciences ; Volume 11 ; Issue 8 (2021)
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