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Move to read: entrainment activities and pre-reading skills of kindergarteners
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Language recovery through a two-stage awake surgery in an aphasic patient with a voluminous left fronto-temporo-insular glioma: case report
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In: ISSN: 0001-6268 ; EISSN: 0942-0940 ; Acta Neurochirurgica ; https://hal.archives-ouvertes.fr/hal-03294416 ; Acta Neurochirurgica, Springer Verlag, 2021, 163 (11), pp.3115-3119. ⟨10.1007/s00701-021-04932-x⟩ (2021)
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The COVID-19 pandemic: An evolving story. Professional and personal insights using self and culture as agents of calm and healing after a year of co-habitation with imminent threat
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In: Research outputs 2014 to 2021 (2021)
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DEV - Development of Temporal Visual Selective Attention in Deaf Children ...
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Capturing Neuroplastic Changes after iTBS in Patients with Post-Stroke Aphasia: A Pilot fMRI Study
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In: Brain Sciences ; Volume 11 ; Issue 11 (2021)
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Visual Perception in Hearing Sign Language Users
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In: Electronic Thesis and Dissertation Repository (2021)
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Temporal Dynamics of Brain White Matter Plasticity in Sighted Subjects during Tactile Braille Learning: A Longitudinal Diffusion Tensor Imaging Study.
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In: The Journal of neuroscience, vol. 41, no. 33, pp. 7076-7085 (2021)
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Neurobehavioral Correlates Associated with Melodic Intonation Therapy for Adults with Nonfluent Aphasia
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In: Public Access Theses, Dissertations, and Student Research from the College of Education and Human Sciences (2021)
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Culture: The Driving Force of Human Cognition
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In: ISSN: 1756-8757 ; EISSN: 1756-8765 ; Topics in cognitive science ; https://hal.archives-ouvertes.fr/hal-02998428 ; Topics in cognitive science, Wiley, 2020, 12 (2), pp.654-672. ⟨10.1111/tops.12372⟩ (2020)
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Is the emergence of speech errors in chronic post-stroke aphasia a result of ongoing compensatory brain plasticity mechanisms?
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Functional compensation of the left inferior longitudinal fasciculus for picture naming
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In: ISSN: 0264-3294 ; EISSN: 1464-0627 ; Cognitive Neuropsychology ; https://hal.archives-ouvertes.fr/hal-02318933 ; Cognitive Neuropsychology, Taylor & Francis (Routledge), 2019, pp.140-157. ⟨10.1080/02643294.2018.1477749⟩ (2019)
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Repetitive transcranial magnetic stimulation in stroke rehabilitation: review of the current evidence and pitfalls
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Neuroplasticity in Aphasia: A Proposed Framework of Language Recovery
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Brain-Derived Neurotrophic Factor Genotype–Specific Differences in Cortical Activation in Chronic Aphasia
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Abstract:
PURPOSE: The brain-derived neurotrophic factor (BDNF) gene has been shown to be important for synaptic plasticity in animal models. Human research has suggested that BDNF genotype may influence stroke recovery. Some studies have suggested a genotype-specific motor-related brain activation in stroke recovery. However, recovery from aphasia in relation to BDNF genotype and language-related brain activation has received limited attention. We aimed to explore functional brain activation by BDNF genotype in individuals with chronic aphasia. Consistent with findings in healthy individuals and individuals with poststroke motor impairment, we hypothesized that, among individuals with aphasia, the presence of the Met allele of the BDNF gene is associated with reduced functional brain activation compared to noncarriers of the Met allele. METHOD: Eighty-seven individuals with chronic stroke-induced aphasia performed a naming task during functional magnetic resonance imaging scanning and submitted blood or saliva samples for BDNF genotyping. The mean number of activated voxels was compared between groups, and group-based activation maps were directly compared. Neuropsychological testing was conducted to compare language impairment between BDNF genotype groups. The Western Aphasia Battery Aphasia Quotient (Kertesz, 2007) was included as a covariate in all analyses. RESULTS: While lesion size was comparable between groups, the amount of activation, quantified as the number of activated voxels, was significantly greater in noncarriers of the Met allele (whole brain: 98,500 vs. 28,630, p < .001; left hemisphere only: 37,209 vs. 7,000, p < .001; right hemisphere only: 74,830 vs. 30,630, p < .001). This difference was most strongly expressed in the right hemisphere posterior temporal area, pre- and postcentral gyrus, and frontal lobe, extending into the white matter. Correspondingly, the atypical BDNF genotype group was found to have significantly less severe aphasia (Western Aphasia Battery Aphasia Quotient of 64.2 vs. 54.3, p = .033) and performed better on a naming task (Philadelphia Naming Test [Roach, Schwartz, Martin, Grewal, & Brecher, 1996] score of 74.7 vs. 52.8, p = .047). A region of interest analysis of intensity of activation revealed no group differences, and a direct comparison of average activation maps across groups similarly yielded null results. CONCLUSION: BDNF genotype mediates cortical brain activation in individuals with chronic aphasia. Correspondingly, individuals carrying the Met allele present with more severe aphasia compared to noncarriers. These findings warrant further study into the effects of BDNF genotype in aphasia. SUPPLEMENTAL MATERIAL: https://doi.org/10.23641/asha.10073147 PRESENTATION VIDEO: https://doi.org/10.23641/asha.10257581
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Keyword:
Forum: Advances in Neuroplasticity Research on Language Recovery in Aphasia
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URL: https://doi.org/10.1044/2019_JSLHR-L-RSNP-19-0021 http://www.ncbi.nlm.nih.gov/pubmed/31756156 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203521/
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The Cognitive and Neural Underpinnings of Language Learning and Processing
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