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1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans
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A Comparison of the ASEBA Adult Self Report (ASR) and the Brief Problem Monitor (BPM/18-59)
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In: Behav Genet (2020)
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Abstract:
The adult self report (ASR) is a well-validated instrument with multiple scales relating to adult psychopathology. Recently, an 18-item version has been introduced, the brief problem monitor (BPM) to measure Internalizing behavior (INT), Externalizing behavior (EXT), and attention problems (ATT). The present study compared the BPM and ASR and investigated how well the BPM can serve as a supplement or an alternative for the ASR for specific clinical and scientific purposes. In a large sample of adult twins (N = 9.835) from the Netherlands Twin Register (NTR), we compared the internal consistency, clinical classification concordance, means, and variances of the ASR and BPM. Using the classical twin design, we investigated the genetic covariance structure. For external validation, the associations between subjective well-being and different subscales of the ASR and BPM were compared. The internal consistency of the BPM scales (around α = 0.75) was somewhat lower than the ASR (α ~ 0.85). The BPM Externalizing scale showed the lowest internal consistency (α = 0.63). ASR and BPM scores showed good clinical classification concordance (0.61–0.80) and high correlations (r > 0.88). A small reversed sex difference in the BPM Externalizing scale appeared (women > men). Genetic (0.34–0.54) and environmental components (0.46–0.66) explained the variance to a similar extent for the ASR and BPM. The phenotypic and genetic associations with well-being were comparable. In situations where sum scores are sufficient, the BPM performs as well as the longer ASR. Depending on the situation and goal, it is worth considering the BPM as an alternative for the ASR to reduce the participant burden. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s10519-020-10001-3) contains supplementary material, which is available to authorized users.
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Keyword:
Original Research
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URL: https://doi.org/10.1007/s10519-020-10001-3 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7441087/ http://www.ncbi.nlm.nih.gov/pubmed/32419065
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Novel genetic loci associated with hippocampal volume
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In: ISSN: 2041-1723 ; EISSN: 2041-1723 ; Nature Communications ; https://hal.archives-ouvertes.fr/hal-01488337 ; Nature Communications, Nature Publishing Group, 2017, 8, pp.13624. ⟨10.1038/ncomms13624⟩ (2017)
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Novel genetic loci underlying human intracranial volume identified through genome-wide association
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In: ISSN: 1097-6256 ; EISSN: 1546-1726 ; Nature Neuroscience ; https://hal.archives-ouvertes.fr/hal-01382716 ; Nature Neuroscience, Nature Publishing Group, 2016, 19 (12), pp.1569-1582. ⟨10.1038/nn.4398⟩ (2016)
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Common genetic variants influence human subcortical brain structures.
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In: ISSN: 0028-0836 ; EISSN: 1476-4679 ; Nature ; https://hal.archives-ouvertes.fr/hal-01196805 ; Nature, Nature Publishing Group, 2015, 520 (7546), pp.224-9. ⟨10.1038/nature14101⟩ (2015)
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Low birth weight in MZ twins discordant for birth weight is associated with shorter telomere length and lower IQ, but not anxiety/depression in later life
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Intelligence: Shared genetic basis between Mendelian disorders and a polygenic trait
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Childhood intelligence is heritable, highly polygenic and associated with FNBP1L
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Genotype by environment interactions in cognitive ability: a survey of 14 studies from four countries covering four age groups
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The ongoing adaptive evolution of ASPM and microcephalin is not explained by increased intelligence
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Genetic Contributions to Human Brain Morphology and Intelligence
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