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1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans
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A Comparison of the ASEBA Adult Self Report (ASR) and the Brief Problem Monitor (BPM/18-59)
In: Behav Genet (2020)
Abstract: The adult self report (ASR) is a well-validated instrument with multiple scales relating to adult psychopathology. Recently, an 18-item version has been introduced, the brief problem monitor (BPM) to measure Internalizing behavior (INT), Externalizing behavior (EXT), and attention problems (ATT). The present study compared the BPM and ASR and investigated how well the BPM can serve as a supplement or an alternative for the ASR for specific clinical and scientific purposes. In a large sample of adult twins (N = 9.835) from the Netherlands Twin Register (NTR), we compared the internal consistency, clinical classification concordance, means, and variances of the ASR and BPM. Using the classical twin design, we investigated the genetic covariance structure. For external validation, the associations between subjective well-being and different subscales of the ASR and BPM were compared. The internal consistency of the BPM scales (around α = 0.75) was somewhat lower than the ASR (α ~ 0.85). The BPM Externalizing scale showed the lowest internal consistency (α = 0.63). ASR and BPM scores showed good clinical classification concordance (0.61–0.80) and high correlations (r > 0.88). A small reversed sex difference in the BPM Externalizing scale appeared (women > men). Genetic (0.34–0.54) and environmental components (0.46–0.66) explained the variance to a similar extent for the ASR and BPM. The phenotypic and genetic associations with well-being were comparable. In situations where sum scores are sufficient, the BPM performs as well as the longer ASR. Depending on the situation and goal, it is worth considering the BPM as an alternative for the ASR to reduce the participant burden. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s10519-020-10001-3) contains supplementary material, which is available to authorized users.
Keyword: Original Research
URL: https://doi.org/10.1007/s10519-020-10001-3
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7441087/
http://www.ncbi.nlm.nih.gov/pubmed/32419065
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3
Novel genetic loci associated with hippocampal volume
In: ISSN: 2041-1723 ; EISSN: 2041-1723 ; Nature Communications ; https://hal.archives-ouvertes.fr/hal-01488337 ; Nature Communications, Nature Publishing Group, 2017, 8, pp.13624. ⟨10.1038/ncomms13624⟩ (2017)
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4
Novel genetic loci underlying human intracranial volume identified through genome-wide association
In: ISSN: 1097-6256 ; EISSN: 1546-1726 ; Nature Neuroscience ; https://hal.archives-ouvertes.fr/hal-01382716 ; Nature Neuroscience, Nature Publishing Group, 2016, 19 (12), pp.1569-1582. ⟨10.1038/nn.4398⟩ (2016)
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5
Common genetic variants influence human subcortical brain structures.
In: ISSN: 0028-0836 ; EISSN: 1476-4679 ; Nature ; https://hal.archives-ouvertes.fr/hal-01196805 ; Nature, Nature Publishing Group, 2015, 520 (7546), pp.224-9. ⟨10.1038/nature14101⟩ (2015)
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6
Genetic Basis of a Cognitive Complexity Metric
Hansell, Narelle K.; Halford, Graeme S.; Andrews, Glenda. - : Public Library of Science, 2015
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7
Genetic basis of a cognitive complexity metric
Hansell, Narelle K.; Halford, Graeme S.; Andrews, Glenda. - : Public Library of Science, 2015
BASE
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8
Low birth weight in MZ twins discordant for birth weight is associated with shorter telomere length and lower IQ, but not anxiety/depression in later life
Strohmaier, Jana; van Dongen, Jenny; Willemsen, Gonneke. - : Cambridge University Press, 2015
BASE
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9
Intelligence: Shared genetic basis between Mendelian disorders and a polygenic trait
Franic, Sanja; Groen-Blokhuis, Maria M.; Dolan, Conor V.. - : Nature Publishing Group, 2015
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10
Childhood intelligence is heritable, highly polygenic and associated with FNBP1L
Benyamin, B.; Pourcain, Bst; Davis, O. S.. - : Nature Publishing Group, 2014
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11
Genotype by environment interactions in cognitive ability: a survey of 14 studies from four countries covering four age groups
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12
Human brain volume : what's in the genes?
In: Handbook of behavior genetics (New York, 2009), p. 137-158
MPI für Psycholinguistik
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13
Genetics of ADHD, hyperactivity, and attention problems
In: Handbook of behavior genetics (New York, 2009), p. 361-378
MPI für Psycholinguistik
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14
Genetic contribution to variation in cognitive function: an fMRI study in twins
In: Science. - Washington, DC : AAAS, American Assoc. for the Advancement of Science 323 (2009) 5922, 1737-1740
BLLDB
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15
Genetic covariance structure of reading, intelligence and memory in children
In: Behavior genetics. - New York, NY : Springer 39 (2009) 3, 245-254
BLLDB
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16
QTL detection in multivariate data from sibling pairs
In: Statistical genetics (New York, NY, 2008), p. 239-264
MPI für Psycholinguistik
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17
The ongoing adaptive evolution of ASPM and microcephalin is not explained by increased intelligence
Mekel-Bobrov, Nitzan; Posthuma, Danielle; Gilbert, Sandra L.. - : Oxford University Press, 2007
BASE
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18
Accounting for Sequential Trial Effects in the Flanker Task: Conflict Adaptation or Associative Priming?
In: Memory & cognition. - Heidelberg [u.a.] : Springer 34 (2006) 6, 1260
OLC Linguistik
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19
Accounting for sequential trial effects in the flanker task: Conflict adaptation or associative priming?
In: Memory & cognition. - Heidelberg [u.a.] : Springer 34 (2006) 6, 1260-1272
OLC Linguistik
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20
Genetic Contributions to Human Brain Morphology and Intelligence
Hulshoff Pol, Hilleke E.; Schnack, Hugo G.; Posthuma, Danielle. - : Society for Neuroscience, 2006
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