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Cortical microstructure in primary progressive aphasia: a multicenter study.
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In: Alzheimer's research & therapy, vol 14, iss 1 (2022)
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Neuroanatomical correlations of visuospatial processing in primary progressive aphasia
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In: Brain Commun (2022)
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Editorial: The Unusual Suspects: Linguistic Deficits in Non-Language-Dominant Neurodegenerative Diseases
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In: Front Aging Neurosci (2022)
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Primary Progressive Aphasia Associated With GRN Mutations: New Insights Into the Non-amyloid Logopenic Variant
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In: ISSN: 0028-3878 ; EISSN: 1526-632X ; Neurology ; https://hal.archives-ouvertes.fr/hal-03281660 ; Neurology, American Academy of Neurology, 2021, ⟨10.1212/wnl.0000000000012174⟩ (2021)
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Uniform data set language measures for bvFTD and PPA diagnosis and monitoring.
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In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021)
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Uniform data set language measures for bvFTD and PPA diagnosis and monitoring.
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In: Alzheimer's & dementia (Amsterdam, Netherlands), vol 13, iss 1 (2021)
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Speech Metrics and Samples That Differentiate Between Nonfluent/Agrammatic and Logopenic Variants of Primary Progressive Aphasia
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In: J Speech Lang Hear Res (2021)
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Treatment for Anomia in Bilingual Speakers with Progressive Aphasia
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In: Brain Sci (2021)
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Cortical Tracking of the Speech Envelope in Logopenic Variant Primary Progressive Aphasia
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In: Front Hum Neurosci (2021)
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Uniform data set language measures for bvFTD and PPA diagnosis and monitoring
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In: Alzheimers Dement (Amst) (2021)
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Association of APOE4 and Clinical Variability in Alzheimer Disease With the Pattern of Tau- and Amyloid-PET
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In: Neurology (2021)
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Connected speech markers of amyloid burden in primary progressive aphasia
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Slegers, Antoine; Chafouleas, Geneviève; Montembeault, Maxime; Bedetti, Christophe; Welch, Ariane E.; Rabinovici, Gil D.; Langlais, Philippe; Gorno-Tempini, Maria Luisa; Brambati, Simona Maria. - : Elsevier, 2021
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Abstract:
INTRODUCTION Positron emission tomography (PET) amyloid imaging has become an important part of the diagnostic workup for patients with primary progressive aphasia (PPA) and uncertain underlying pathology. Here, we employ a semi-automated analysis of connected speech (CS) with a twofold objective. First, to determine if quantitative CS features can help select primary progressive aphasia (PPA) patients with a higher probability of a positive PET amyloid imaging result. Second, to examine the relevant group differences from a clinical perspective. METHODS 117 CS samples from a well-characterised cohort of PPA patients who underwent PET amyloid imaging were collected. Expert consensus established PET amyloid status for each patient, and 40% of the sample was amyloid positive. RESULTS Leave-one-out cross-validation yields 77% classification accuracy (sensitivity: 74%, specificity: 79%). DISCUSSION Our results confirm the potential of CS analysis as a screening tool. Discriminant CS features from lexical, syntactic, pragmatic, and semantic domains are discussed.
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Keyword:
Alzheimer’s disease; Biomarkers; Connected speech; Differential diagnosis; Natural language processing; Primary progressive aphasia; Telemedicine
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URL: http://hdl.handle.net/1866/25767
https://doi.org/10.1016/j.cortex.2021.09.010
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| 13 |
Diagnostic Assessment in Primary Progressive Aphasia: An Illustrative Case Example
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Deformation-based shape analysis of the hippocampus in the semantic variant of primary progressive aphasia and Alzheimer's disease.
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Deformation-based shape analysis of the hippocampus in the semantic variant of primary progressive aphasia and Alzheimer's disease.
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Data-Driven, Visual Framework for the Characterization of Aphasias Across Stroke, Post-resective, and Neurodegenerative Disorders Over Time.
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Speech and language therapy approaches to managing primary progressive aphasia
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Primary progressive aphasia and the FTD-MND spectrum disorders: clinical, pathological, and neuroimaging correlates ...
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