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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Page: 1 2 3 4 5...10 Hits 1 – 20 of 191 1 Utilising a systematic review-based approach to create a database of individual participant data for meta- and network meta-analyses: The RELEASE database of aphasia after stroke Williams, Louise R.; Ali, Myzoon; VandenBerg, Kathryn... In: Research outputs 2014 to 2021 (2022) BASE Show details 2 Training flexible conceptual retrieval in post-stroke aphasia Stampacchia, Sara; Smallwood, Jonathan; Thompson, Hannah E.. - 2021 BASE Show details 3 Language Disorder in Progressive Supranuclear Palsy and Corticobasal Syndrome: Neural Correlates and Detection by the MLSE Screening Tool. ... Peterson, Katie A; Jones, P Simon; Patel, Nikil. - : Apollo - University of Cambridge Repository, 2021 BASE Show details 4 Auditory beat perception is related to speech output fluency in post-stroke aphasia ... Stefaniak, James D.; Lambon Ralph, Matthew A.; De Dios Perez, Blanca. - : Apollo - University of Cambridge Repository, 2021 BASE Show details 5 Language Disorder in Progressive Supranuclear Palsy and Corticobasal Syndrome: Neural Correlates and Detection by the MLSE Screening Tool ... Peterson, Katie A.; Jones, P. Simon; Patel, Nikil. - : Apollo - University of Cambridge Repository, 2021 BASE Show details 6 Language Disorder in Progressive Supranuclear Palsy and Corticobasal Syndrome: Neural Correlates and Detection by the MLSE Screening Tool Peterson, Katie A.; Jones, P. Simon; Patel, Nikil... In: Front Aging Neurosci (2021) BASE Show details 7 Training flexible conceptual retrieval in post-stroke aphasia Hallam, Glyn P.; Nathaniel, Upasana; Lambon Ralph, Matthew A.... In: ISSN: 0960-2011 ; Neuropsychological Rehabilitation (2021) pp. 1-27 (2021) BASE Show details 8 Auditory beat perception is related to speech output fluency in post-stroke aphasia Stefaniak, James D.; Lambon Ralph, Matthew A.; De Dios Perez, Blanca. - : Nature Publishing Group UK, 2021. : Scientific Reports, 2021 BASE Show details 9 Language Disorder in Progressive Supranuclear Palsy and Corticobasal Syndrome: Neural Correlates and Detection by the MLSE Screening Tool Peterson, Katie A.; Jones, P. Simon; Patel, Nikil. - : Frontiers Media S.A., 2021. : Frontiers in Aging Neuroscience, 2021 BASE Show details 10 Language Disorder in Progressive Supranuclear Palsy and Corticobasal Syndrome: Neural Correlates and Detection by the MLSE Screening Tool. Peterson, Katie A; Jones, P Simon; Patel, Nikil... In: essn: 1663-4365 ; nlmid: 101525824 (2021) BASE Show details 11 The neural bases of resilient semantic system: evidence of variable neuro-displacement in cognitive systems Jung, Je Young; Rice, Grace E.; Lambon Ralph, Matthew A. In: Brain Struct Funct (2021) BASE Show details 12 Multiple dimensions underlying the functional organization of the language network Hodgson, Victoria J.; Lambon Ralph, Matthew A.; Jackson, Rebecca L. In: Neuroimage (2021) BASE Show details 13 Graded, multidimensional intra- and intergroup variations in primary progressive aphasia and post-stroke aphasia. Ingram, Ruth U; Halai, Ajay D; Pobric, Gorana... In: Brain : a journal of neurology, vol 143, iss 10 (2020) BASE Show details 14 RELEASE: A protocol for a systematic review based, individual participant data, meta- and network meta-analysis, of complex speech-language therapy interventions for stroke-related aphasia Brady, Marian C.; Ali, Myzoon; VandenBerg, Kathryn... In: Research outputs 2014 to 2021 (2020) BASE Show details 15 Bipartite Functional Fractionation within the Default Network Supports Disparate Forms of Internally Oriented Cognition Chiou, Rocco; Humphreys, Gina F; Lambon Ralph, Matthew A In: Cereb Cortex (2020) BASE Show details 16 RELEASE: a protocol for a systematic review based, individual participant data, meta- and network meta-analysis, of complex speech-language therapy interventions for stroke-related aphasia Brady, Marian C.; Ali, Myzoon; VandenBerg, Kathryn. - : Taylor & Francis, 2020 BASE Show details 17 A unified neurocomputational bilateral model of spoken language production in healthy participants and recovery in poststroke aphasia Chang, Ya-Ning; Lambon Ralph, Matthew A. In: Proc Natl Acad Sci U S A (2020) BASE Show details 18 Investigating the effect of changing parameters when building prediction models in post-stroke aphasia Halai, Ajay D.; Woollams, Anna M.; Lambon Ralph, Matthew A. In: Nat Hum Behav (2020) BASE Show details 19 Redefining the multidimensional clinical phenotypes of frontotemporal lobar degeneration syndromes Murley, Alexander G; Coyle-Gilchrist, Ian; Rouse, Matthew A... In: Brain (2020) BASE Show details 20 Establishing two principal dimensions of cognitive variation in logopenic progressive aphasia Ramanan, Siddharth; Roquet, Daniel; Goldberg, Zoë-Lee; Hodges, John R; Piguet, Olivier; Irish, Muireann; Lambon Ralph, Matthew A In: Brain Commun (2020) Abstract: Logopenic progressive aphasia is a neurodegenerative syndrome characterized by sentence repetition and naming difficulties arising from left-lateralized temporoparietal atrophy. Clinical descriptions of logopenic progressive aphasia largely concentrate on profiling language deficits, however, accumulating evidence points to the presence of cognitive deficits even on tasks with minimal language demands. Although non-linguistic cognitive deficits in logopenic progressive aphasia are thought to scale with disease severity, patients at discrete stages of language dysfunction display overlapping cognitive profiles, suggesting individual-level variation in cognitive performance, independent of primary language dysfunction. To address this issue, we used principal component analysis to decompose the individual-level variation in cognitive performance in 43 well-characterized logopenic progressive aphasia patients who underwent multi-domain neuropsychological assessments and structural neuroimaging. The principal component analysis solution revealed the presence of two, statistically independent factors, providing stable and clinically intuitive explanations for the majority of variance in cognitive performance in the syndrome. Factor 1 reflected ‘speech production and verbal memory’ deficits which typify logopenic progressive aphasia. Systematic variations were also confirmed on a second, orthogonal factor mainly comprising visuospatial and executive processes. Adopting a case-comparison approach, we further demonstrate that pairs of patients with comparable Factor 1 scores, regardless of their severity, diverge considerably on visuo-executive test performance, underscoring the inter-individual variability in cognitive profiles in comparably ‘logopenic’ patients. Whole-brain voxel-based morphometry analyses revealed that speech production and verbal memory factor scores correlated with left middle frontal gyrus, while visuospatial and executive factor scores were associated with grey matter intensity of right-lateralized temporoparietal, middle frontal regions and their underlying white matter connectivity. Importantly, logopenic progressive aphasia patients with poorer visuospatial and executive factor scores demonstrated greater right-lateralized temporoparietal and frontal atrophy. Our findings demonstrate the inherent variation in cognitive performance at an individual- and group-level in logopenic progressive aphasia, suggesting the presence of a genuine co-occurring cognitive impairment that is statistically independent of language function and disease severity. Keyword: Original Article URL: http://www.ncbi.nlm.nih.gov/pubmed/33376980 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7750924/ https://doi.org/10.1093/braincomms/fcaa125 BASE Hide details Page: 1 2 3 4 5...10

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