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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Page: 1 2 3 4 5...10 Hits 1 – 20 of 191 1 Utilising a systematic review-based approach to create a database of individual participant data for meta- and network meta-analyses: The RELEASE database of aphasia after stroke Williams, Louise R.; Ali, Myzoon; VandenBerg, Kathryn... In: Research outputs 2014 to 2021 (2022) BASE Show details 2 Training flexible conceptual retrieval in post-stroke aphasia Stampacchia, Sara; Smallwood, Jonathan; Thompson, Hannah E.. - 2021 BASE Show details 3 Language Disorder in Progressive Supranuclear Palsy and Corticobasal Syndrome: Neural Correlates and Detection by the MLSE Screening Tool. ... Peterson, Katie A; Jones, P Simon; Patel, Nikil. - : Apollo - University of Cambridge Repository, 2021 BASE Show details 4 Auditory beat perception is related to speech output fluency in post-stroke aphasia ... Stefaniak, James D.; Lambon Ralph, Matthew A.; De Dios Perez, Blanca. - : Apollo - University of Cambridge Repository, 2021 BASE Show details 5 Language Disorder in Progressive Supranuclear Palsy and Corticobasal Syndrome: Neural Correlates and Detection by the MLSE Screening Tool ... Peterson, Katie A.; Jones, P. Simon; Patel, Nikil. - : Apollo - University of Cambridge Repository, 2021 BASE Show details 6 Language Disorder in Progressive Supranuclear Palsy and Corticobasal Syndrome: Neural Correlates and Detection by the MLSE Screening Tool Peterson, Katie A.; Jones, P. Simon; Patel, Nikil... In: Front Aging Neurosci (2021) BASE Show details 7 Training flexible conceptual retrieval in post-stroke aphasia Hallam, Glyn P.; Nathaniel, Upasana; Lambon Ralph, Matthew A.... In: ISSN: 0960-2011 ; Neuropsychological Rehabilitation (2021) pp. 1-27 (2021) BASE Show details 8 Auditory beat perception is related to speech output fluency in post-stroke aphasia Stefaniak, James D.; Lambon Ralph, Matthew A.; De Dios Perez, Blanca. - : Nature Publishing Group UK, 2021. : Scientific Reports, 2021 BASE Show details 9 Language Disorder in Progressive Supranuclear Palsy and Corticobasal Syndrome: Neural Correlates and Detection by the MLSE Screening Tool Peterson, Katie A.; Jones, P. Simon; Patel, Nikil. - : Frontiers Media S.A., 2021. : Frontiers in Aging Neuroscience, 2021 BASE Show details 10 Language Disorder in Progressive Supranuclear Palsy and Corticobasal Syndrome: Neural Correlates and Detection by the MLSE Screening Tool. Peterson, Katie A; Jones, P Simon; Patel, Nikil... In: essn: 1663-4365 ; nlmid: 101525824 (2021) BASE Show details 11 The neural bases of resilient semantic system: evidence of variable neuro-displacement in cognitive systems Jung, Je Young; Rice, Grace E.; Lambon Ralph, Matthew A. In: Brain Struct Funct (2021) BASE Show details 12 Multiple dimensions underlying the functional organization of the language network Hodgson, Victoria J.; Lambon Ralph, Matthew A.; Jackson, Rebecca L. In: Neuroimage (2021) BASE Show details 13 Graded, multidimensional intra- and intergroup variations in primary progressive aphasia and post-stroke aphasia. Ingram, Ruth U; Halai, Ajay D; Pobric, Gorana... In: Brain : a journal of neurology, vol 143, iss 10 (2020) BASE Show details 14 RELEASE: A protocol for a systematic review based, individual participant data, meta- and network meta-analysis, of complex speech-language therapy interventions for stroke-related aphasia Brady, Marian C.; Ali, Myzoon; VandenBerg, Kathryn... In: Research outputs 2014 to 2021 (2020) BASE Show details 15 Bipartite Functional Fractionation within the Default Network Supports Disparate Forms of Internally Oriented Cognition Chiou, Rocco; Humphreys, Gina F; Lambon Ralph, Matthew A In: Cereb Cortex (2020) BASE Show details 16 RELEASE: a protocol for a systematic review based, individual participant data, meta- and network meta-analysis, of complex speech-language therapy interventions for stroke-related aphasia Brady, Marian C.; Ali, Myzoon; VandenBerg, Kathryn. - : Taylor & Francis, 2020 BASE Show details 17 A unified neurocomputational bilateral model of spoken language production in healthy participants and recovery in poststroke aphasia Chang, Ya-Ning; Lambon Ralph, Matthew A. In: Proc Natl Acad Sci U S A (2020) BASE Show details 18 Investigating the effect of changing parameters when building prediction models in post-stroke aphasia Halai, Ajay D.; Woollams, Anna M.; Lambon Ralph, Matthew A. In: Nat Hum Behav (2020) BASE Show details 19 Redefining the multidimensional clinical phenotypes of frontotemporal lobar degeneration syndromes Murley, Alexander G; Coyle-Gilchrist, Ian; Rouse, Matthew A; Jones, P Simon; Li, Win; Wiggins, Julie; Lansdall, Claire; Rodríguez, Patricia Vázquez; Wilcox, Alicia; Tsvetanov, Kamen A; Patterson, Karalyn; Lambon Ralph, Matthew A; Rowe, James B In: Brain (2020) Abstract: The syndromes caused by frontotemporal lobar degeneration have highly heterogeneous and overlapping clinical features. There has been great progress in the refinement of clinical diagnostic criteria in the past decade, but we propose that a better understanding of aetiology, pathophysiology and symptomatic treatments can arise from a transdiagnostic approach to clinical phenotype and brain morphometry. In a cross-sectional epidemiological study, we examined 310 patients with a syndrome likely to be caused by frontotemporal lobar degeneration, including behavioural variant frontotemporal dementia, non-fluent, and semantic variants of primary progressive aphasia (PPA), progressive supranuclear palsy and corticobasal syndrome. We included patients with logopenic PPA and those who met criteria for PPA but not a specific subtype. To date, 49 patients have a neuropathological diagnosis. A principal component analysis identified symptom dimensions that broadly recapitulated the core features of the main clinical syndromes. However, the subject-specific scores on these dimensions showed considerable overlap across the diagnostic groups. Sixty-two per cent of participants had phenotypic features that met the diagnostic criteria for more than one syndrome. Behavioural disturbance was prevalent in all groups. Forty-four per cent of patients with corticobasal syndrome had progressive supranuclear palsy-like features and 30% of patients with progressive supranuclear palsy had corticobasal syndrome-like features. Many patients with progressive supranuclear palsy and corticobasal syndrome had language impairments consistent with non-fluent variant PPA while patients with behavioural variant frontotemporal dementia often had semantic impairments. Using multivariate source-based morphometry on a subset of patients (n = 133), we identified patterns of covarying brain atrophy that were represented across the diagnostic groups. Canonical correlation analysis of clinical and imaging components found three key brain-behaviour relationships, with a continuous spectrum across the cohort rather than discrete diagnostic entities. In the 46 patients with follow-up (mean 3.6 years) syndromic overlap increased with time. Together, these results show that syndromes associated with frontotemporal lobar degeneration do not form discrete mutually exclusive categories from their clinical features or structural brain changes, but instead exist in a multidimensional spectrum. Patients often manifest diagnostic features of multiple disorders while deficits in behaviour, movement and language domains are not confined to specific diagnostic groups. It is important to recognize individual differences in clinical phenotype, both for clinical management and to understand pathogenic mechanisms. We suggest that a transdiagnostic approach to the spectrum of frontotemporal lobar degeneration syndromes provides a useful framework with which to understand disease aetiology, progression, and heterogeneity and to target future treatments to a higher proportion of patients. Keyword: Original Articles URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241953/ https://doi.org/10.1093/brain/awaa097 http://www.ncbi.nlm.nih.gov/pubmed/32438414 BASE Hide details 20 Establishing two principal dimensions of cognitive variation in logopenic progressive aphasia Ramanan, Siddharth; Roquet, Daniel; Goldberg, Zoë-Lee... In: Brain Commun (2020) BASE Show details Page: 1 2 3 4 5...10

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