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Lifelong bilingualism and mechanisms of neuroprotection in Alzheimer dementia. ...
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Lifelong bilingualism and mechanisms of neuroprotection in Alzheimer dementia.
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Speech production differences in English and Italian speakers with nonfluent variant PPA
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In: Neurology (2020)
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The clinico-metabolic correlates of language impairment in corticobasal syndrome and progressive supranuclear palsy
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In: ISSN: 2213-1582 ; NeuroImage: Clinical (2019) P. 102009 (2019)
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Northwestern Anagram Test-Italian (Nat-I) for primary progressive aphasia
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In: Cortex (2019)
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Prevalence of amyloid‐β pathology in distinct variants of primary progressive aphasia
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In: ISSN: 0364-5134 ; EISSN: 1531-8249 ; Annals of Neurology ; https://hal-univ-fcomte.archives-ouvertes.fr/hal-03630161 ; Annals of Neurology, Wiley, 2018, 84 (5), pp.729-740. ⟨10.1002/ana.25333⟩ (2018)
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Prevalence of amyloid‐β pathology in distinct variants of primary progressive aphasia
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In: ISSN: 0364-5134 ; EISSN: 1531-8249 ; Annals of Neurology ; https://www.hal.inserm.fr/inserm-02749861 ; Annals of Neurology, Wiley, 2018, 84 (5), pp.729-740. ⟨10.1002/ana.25333⟩ (2018)
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Prevalence of Amyloid-β Pathology in Distinct Variants of Primary Progressive Aphasia
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Prevalence of amyloid-β pathology in distinct variants of primary progressive aphasia: Amyloid-β Pathology in PPA
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In: Annals of Neurology. - 84, 5 (2018) , 729-740, ISSN: 0364-5134 (2018)
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The impact of bilingualism on brain reserve and metabolic connectivity in Alzheimer's dementia
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The Role of Single-Subject Brain Metabolic Patterns in the Early Differential Diagnosis of Primary Progressive Aphasias and in Prediction of Progression to Dementia
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A multimodal neuroimaging study of a case of crossed nonfluent/agrammatic primary progressive aphasia
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The Semantic Variant of Primary Progressive Aphasia: Clinical and Neuroimaging Evidence in Single Subjects
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In vivo signatures of nonfluent/agrammatic primary progressive aphasia caused by FTLD pathology
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In vivo signatures of nonfluent/agrammatic primary progressive aphasia caused by FTLD pathology
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Nonfluent/agrammatic PPA with in-vivo cortical amyloidosis and Pick's disease pathology.
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Caso, Francesca; Gesierich, Benno; Henry, Maya; Sidhu, Manu; LaMarre, Amanda; Babiak, Miranda; Miller, Bruce L; Rabinovici, Gil D; Huang, Eric J; Magnani, Giuseppe; Filippi, Massimo; Comi, Giancarlo; Seeley, William W; Gorno-Tempini, Maria Luisa
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In: Behavioural neurology, vol 26, iss 1-2 (2013)
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Abstract:
The role of biomarkers in predicting pathological findings in the frontotemporal dementia (FTD) clinical spectrum disorders is still being explored. We present comprehensive, prospective longitudinal data for a 66 year old, right-handed female who met current criteria for the nonfluent/agrammatic variant of primary progressive aphasia (nfvPPA). She first presented with a 3-year history of progressive speech and language impairment mainly characterized by severe apraxia of speech. Neuropsychological and general motor functions remained relatively spared throughout the clinical course. Voxel-based morphometry (VBM) showed selective cortical atrophy of the left posterior inferior frontal gyrus (IFG) and underlying insula that worsened over time, extending along the left premotor strip. Five years after her first evaluation, she developed mild memory impairment and underwent PET-FDG and PiB scans that showed left frontal hypometabolism and cortical amyloidosis. Three years later (11 years from first symptom), post-mortem histopathological evaluation revealed Pick's disease, with severe degeneration of left IFG, mid-insula, and precentral gyrus. Alzheimer's disease (AD) (CERAD frequent/Braak Stage V) was also detected. This patient demonstrates that biomarkers indicating brain amyloidosis should not be considered conclusive evidence that AD pathology accounts for a typical FTD clinical/anatomical syndrome.
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Keyword:
Aged; Alzheimer Disease; Amyloidosis; Aniline Compounds; apraxia of speech; Carbon Radioisotopes; Clinical Sciences; Cognitive Sciences; Disease Progression; Experimental Psychology; Female; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Frontal Lobe; Frontotemporal dementia; Functional Neuroimaging; Humans; Magnetic Resonance Imaging; Neuropsychological Tests; Neurosciences; Nonfluent primary progressive aphasia; PiB-PET; Pick Disease of the Brain; Pick's disease; Positron-Emission Tomography; PPA; Primary Progressive Nonfluent Aphasia; Thiazoles; Voxel-based morphometry
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URL: https://escholarship.org/uc/item/8wt9b744
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Nonfluent/agrammatic PPA with in-vivo cortical amyloidosis and Pick’s disease pathology
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