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Primary Progressive Aphasia Associated With GRN Mutations: New Insights Into the Non-amyloid Logopenic Variant
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In: ISSN: 0028-3878 ; EISSN: 1526-632X ; Neurology ; https://hal.archives-ouvertes.fr/hal-03281660 ; Neurology, American Academy of Neurology, 2021, ⟨10.1212/wnl.0000000000012174⟩ (2021)
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Cognitive and behavioural inhibition deficits in neurodegenerative dementias
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In: Cortex (2020)
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Testing the therapeutic effects of transcranial direct current stimulation (tDCS) in semantic dementia: a double blind, sham controlled, randomized clinical trial
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In: ISSN: 1745-6215 ; Trials ; https://hal.sorbonne-universite.fr/hal-02407657 ; Trials, BioMed Central, 2019, 20 (1), pp.632. ⟨10.1186/s13063-019-3613-z⟩ (2019)
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Testing the therapeutic effects of transcranial direct current stimulation (tDCS) in semantic dementia: a double blind, sham controlled, randomized clinical trial ...
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Testing the therapeutic effects of transcranial direct current stimulation (tDCS) in semantic dementia: a double blind, sham controlled, randomized clinical trial ...
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Testing the therapeutic effects of transcranial direct current stimulation (tDCS) in semantic dementia: a double blind, sham controlled, randomized clinical trial
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Testing the therapeutic effects of transcranial direct current stimulation (tDCS) in semantic dementia: a double blind, sham controlled, randomized clinical trial
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Parietal involvement in the semantic variant of primary progressive aphasia with Alzheimer's disease CSF profile
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In: ISSN: 1387-2877 ; Journal of Alzheimer's Disease ; https://hal.sorbonne-universite.fr/hal-01928504 ; Journal of Alzheimer's Disease, IOS Press, 2018, 66 (1), pp.271 - 280. ⟨10.3233/JAD-180087⟩ (2018)
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Clinical, Anatomical, and Pathological Features in the Three Variants of Primary Progressive Aphasia: A Review
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In: ISSN: 1664-2295 ; Frontiers in Neurology ; https://hal.sorbonne-universite.fr/hal-01867918 ; Frontiers in Neurology, Frontiers, 2018, 9, pp.692. ⟨10.3389/fneur.2018.00692⟩ (2018)
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Clinical, Anatomical, and Pathological Features in the Three Variants of Primary Progressive Aphasia: A Review
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Clinical, anatomical and pathological features in the three variants of primary progressive aphasia : a review
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The Brain Network of Naming: A Lesson from Primary Progressive Aphasia
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In: ISSN: 1932-6203 ; EISSN: 1932-6203 ; PLoS ONE ; https://hal.sorbonne-universite.fr/hal-01294408 ; PLoS ONE, Public Library of Science, 2016, 11 (2), pp.e0148707. ⟨10.1371/journal.pone.0148707⟩ (2016)
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The Brain Network of Naming: A Lesson from Primary Progressive Aphasia
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Deciphering logopenic primary progressive aphasia: a clinical, imaging and biomarker investigation.
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In: ISSN: 0006-8950 ; EISSN: 1460-2156 ; Brain - A Journal of Neurology ; https://hal.inria.fr/hal-00938644 ; Brain - A Journal of Neurology , Oxford University Press (OUP), 2013, 136 (11), pp.3474-3488. ⟨10.1093/brain/awt266⟩ (2013)
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Logopenic progressive aphasia beyond Alzheimer's--an evolution towards dementia with Lewy bodies
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Logopenic progressive aphasia beyond Alzheimer's--an evolution towards dementia with Lewy bodies
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Language networks in semantic dementia
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Agosta, Federica; Henry, Roland G.; Migliaccio, Raffaella; Neuhaus, John; Miller, Bruce L.; Dronkers, Nina F.; Brambati, Simona M.; Filippi, Massimo; Ogar, Jennifer M.; Wilson, Stephen M.; Gorno-Tempini, Maria Luisa. - : Oxford University Press, 2010
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Abstract:
Cognitive deficits in semantic dementia have been attributed to anterior temporal lobe grey matter damage; however, key aspects of the syndrome could be due to altered anatomical connectivity between language pathways involving the temporal lobe. The aim of this study was to investigate the left language-related cerebral pathways in semantic dementia using diffusion tensor imaging-based tractography and to combine the findings with cortical anatomical and functional magnetic resonance imaging data obtained during a reading activation task. The left inferior longitudinal fasciculus, arcuate fasciculus and fronto-parietal superior longitudinal fasciculus were tracked in five semantic dementia patients and eight healthy controls. The left uncinate fasciculus and the genu and splenium of the corpus callosum were also obtained for comparison with previous studies. From each tract, mean diffusivity, fractional anisotropy, as well as parallel and transverse diffusivities were obtained. Diffusion tensor imaging results were related to grey and white matter atrophy volume assessed by voxel-based morphometry and functional magnetic resonance imaging activations during a reading task. Semantic dementia patients had significantly higher mean diffusivity, parallel and transverse in the inferior longitudinal fasciculus. The arcuate and uncinate fasciculi demonstrated significantly higher mean diffusivity, parallel and transverse and significantly lower fractional anisotropy. The fronto-parietal superior longitudinal fasciculus was relatively spared, with a significant difference observed for transverse diffusivity and fractional anisotropy, only. In the corpus callosum, the genu showed lower fractional anisotropy compared with controls, while no difference was found in the splenium. The left parietal cortex did not show significant volume changes on voxel-based morphometry and demonstrated normal functional magnetic resonance imaging activation in response to reading items that stress sublexical phonological processing. This study shows that semantic dementia is associated with anatomical damage to the major superior and inferior temporal white matter connections of the left hemisphere likely involved in semantic and lexical processes, with relative sparing of the fronto-parietal superior longitudinal fasciculus. Fronto-parietal regions connected by this tract were activated normally in the same patients during sublexical reading. These findings contribute to our understanding of the anatomical changes that occur in semantic dementia, and may further help to explain the dissociation between marked single-word and object knowledge deficits, but sparing of phonology and fluency in semantic dementia.
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Keyword:
Original Articles
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URL: http://brain.oxfordjournals.org/cgi/content/short/133/1/286 https://doi.org/10.1093/brain/awp233
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