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Primary Progressive Aphasia Associated With GRN Mutations: New Insights Into the Non-amyloid Logopenic Variant
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In: ISSN: 0028-3878 ; EISSN: 1526-632X ; Neurology ; https://hal.archives-ouvertes.fr/hal-03281660 ; Neurology, American Academy of Neurology, 2021, ⟨10.1212/wnl.0000000000012174⟩ (2021)
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| 2 |
Cognitive and behavioural inhibition deficits in neurodegenerative dementias
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In: Cortex (2020)
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Testing the therapeutic effects of transcranial direct current stimulation (tDCS) in semantic dementia: a double blind, sham controlled, randomized clinical trial
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In: ISSN: 1745-6215 ; Trials ; https://hal.sorbonne-universite.fr/hal-02407657 ; Trials, BioMed Central, 2019, 20 (1), pp.632. ⟨10.1186/s13063-019-3613-z⟩ (2019)
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| 4 |
Testing the therapeutic effects of transcranial direct current stimulation (tDCS) in semantic dementia: a double blind, sham controlled, randomized clinical trial ...
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| 5 |
Testing the therapeutic effects of transcranial direct current stimulation (tDCS) in semantic dementia: a double blind, sham controlled, randomized clinical trial ...
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| 6 |
Testing the therapeutic effects of transcranial direct current stimulation (tDCS) in semantic dementia: a double blind, sham controlled, randomized clinical trial
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| 7 |
Testing the therapeutic effects of transcranial direct current stimulation (tDCS) in semantic dementia: a double blind, sham controlled, randomized clinical trial
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| 8 |
Parietal involvement in the semantic variant of primary progressive aphasia with Alzheimer's disease CSF profile
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In: ISSN: 1387-2877 ; Journal of Alzheimer's Disease ; https://hal.sorbonne-universite.fr/hal-01928504 ; Journal of Alzheimer's Disease, IOS Press, 2018, 66 (1), pp.271 - 280. ⟨10.3233/JAD-180087⟩ (2018)
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| 9 |
Clinical, Anatomical, and Pathological Features in the Three Variants of Primary Progressive Aphasia: A Review
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In: ISSN: 1664-2295 ; Frontiers in Neurology ; https://hal.sorbonne-universite.fr/hal-01867918 ; Frontiers in Neurology, Frontiers, 2018, 9, pp.692. ⟨10.3389/fneur.2018.00692⟩ (2018)
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| 10 |
Clinical, Anatomical, and Pathological Features in the Three Variants of Primary Progressive Aphasia: A Review
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| 11 |
Clinical, anatomical and pathological features in the three variants of primary progressive aphasia : a review
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Abstract:
Primary progressive aphasias (PPA) are neurodegenerative diseases clinically characterized by an early and relatively isolated language impairment. Three main clinical variants, namely the nonfluent/agrammatic variant (nfvPPA), the semantic variant (svPPA), and the logopenic variant (lvPPA) have been described, each with specific linguistic/cognitive deficits, corresponding anatomical and most probable pathological features. Since the discovery and the development of diagnostic criteria for the PPA variants by the experts in the field, significant progress has been made in the understanding of these diseases. This review aims to provide an overview of the literature on each of the PPA variant in terms of their clinical, anatomical and pathological features, with a specific focus on recent findings. In terms of clinical advancements, recent studies have allowed a better characterization and differentiation of PPA patients based on both their linguistic and non-linguistic profiles. In terms of neuroimaging, techniques such as diffusion imaging and resting-state fMRI have allowed a deeper understanding of the impact of PPA on structural and functional connectivity alterations beyond the well-defined pattern of regional gray matter atrophy. Finally, in terms of pathology, despite significant advances, clinico-pathological correspondence in PPA remains far from absolute. Nonetheless, the improved characterization of PPA has the potential to have a positive impact on the management of patients. Improved reliability of diagnoses and the development of reliable in vivo biomarkers for underlying neuropathology will also be increasingly important in the future as trials for etiology-specific treatments become available.
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Keyword:
Brain connectivity; Language; Logopenic variant; Nonfluent/agrammatic variant; Primary progressive aphasia; Semantic variant
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URL: http://hdl.handle.net/1866/21980
https://doi.org/10.3389/fneur.2018.00692
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| 12 |
The Brain Network of Naming: A Lesson from Primary Progressive Aphasia
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In: ISSN: 1932-6203 ; EISSN: 1932-6203 ; PLoS ONE ; https://hal.sorbonne-universite.fr/hal-01294408 ; PLoS ONE, Public Library of Science, 2016, 11 (2), pp.e0148707. ⟨10.1371/journal.pone.0148707⟩ (2016)
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| 13 |
The Brain Network of Naming: A Lesson from Primary Progressive Aphasia
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| 14 |
Deciphering logopenic primary progressive aphasia: a clinical, imaging and biomarker investigation.
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In: ISSN: 0006-8950 ; EISSN: 1460-2156 ; Brain - A Journal of Neurology ; https://hal.inria.fr/hal-00938644 ; Brain - A Journal of Neurology , Oxford University Press (OUP), 2013, 136 (11), pp.3474-3488. ⟨10.1093/brain/awt266⟩ (2013)
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| 15 |
Logopenic progressive aphasia beyond Alzheimer's--an evolution towards dementia with Lewy bodies
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| 16 |
Logopenic progressive aphasia beyond Alzheimer's--an evolution towards dementia with Lewy bodies
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