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Crossed cerebellar diaschisis on 18 F-FDG PET: Frequency across neurodegenerative syndromes and association with 11 C-PIB and 18 F-Flortaucipir ...
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Crossed cerebellar diaschisis on 18 F-FDG PET: Frequency across neurodegenerative syndromes and association with 11 C-PIB and 18 F-Flortaucipir ...
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Provost, Karine; Joie, Renaud La; Strom, Amelia; Iaccarino, Leonardo; Edwards, Lauren; Mellinger, Taylor J; Pham, Julie; Baker, Suzanne L; Miller, Bruce L; Jagust, William J; Rabinovici, Gil D. - : SAGE Journals, 2021
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Abstract:
We used 18 F-FDG-PET to investigate the frequency of crossed cerebellar diaschisis (CCD) in 197 patients with various syndromes associated with neurodegenerative diseases. In a subset of 117 patients, we studied relationships between CCD and cortical asymmetry of Alzheimer’s pathology (β-amyloid ( 11 C-PIB) and tau ( 18 F-Flortaucipir)). PET images were processed using MRIs to derive parametric SUVR images and define regions of interest. Indices of asymmetry were calculated in the cerebral cortex, basal ganglia and cerebellar cortex. Across all patients, cerebellar 18 F-FDG asymmetry was associated with reverse asymmetry of 18 F-FDG in the cerebral cortex (especially frontal and parietal areas) and basal ganglia. Based on our operational definition (cerebellar asymmetry >3% with contralateral supratentorial hypometabolism), significant CCD was present in 47/197 (24%) patients and was most frequent in corticobasal syndrome and semantic and logopenic variants of primary progressive aphasia. In ...
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Keyword:
110305 Emergency Medicine; 110306 Endocrinology; 110320 Radiology and Organ Imaging; 110904 Neurology and Neuromuscular Diseases; 69999 Biological Sciences not elsewhere classified; Biochemistry; Cell Biology; FOS Biological sciences; FOS Clinical medicine; Medicine; Neuroscience
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URL: https://dx.doi.org/10.25384/sage.c.5337896.v1 https://sage.figshare.com/collections/Crossed_cerebellar_diaschisis_on_sup_18_sup_F-FDG_PET_Frequency_across_neurodegenerative_syndromes_and_association_with_sup_11_sup_C-PIB_and_sup_18_sup_F-Flortaucipir/5337896/1
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Crossed cerebellar diaschisis on (18)F-FDG PET: Frequency across neurodegenerative syndromes and association with (11)C-PIB and (18)F-Flortaucipir
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In: J Cereb Blood Flow Metab (2021)
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Association of APOE4 and Clinical Variability in Alzheimer Disease With the Pattern of Tau- and Amyloid-PET
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In: Neurology (2021)
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Connected speech markers of amyloid burden in primary progressive aphasia
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Diagnostic Assessment in Primary Progressive Aphasia: An Illustrative Case Example
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Diagnostic Assessment in Primary Progressive Aphasia: An Illustrative Case Example
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In: Am J Speech Lang Pathol (2020)
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Longitudinal structural and metabolic changes in frontotemporal dementia
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In: Neurology (2020)
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Effects of bilingualism on age of onset in two clinical Alzheimer’s disease variants
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In: Alzheimers Dement (2020)
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Cortical developmental abnormalities in logopenic variant primary progressive aphasia with dyslexia.
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In: Brain communications, vol 1, iss 1 (2019)
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Cortical developmental abnormalities in logopenic variant primary progressive aphasia with dyslexia.
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In: Brain communications, vol 1, iss 1 (2019)
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Alzheimer’s disease clinical variants show distinct regional patterns of neurofibrillary tangle accumulation
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Cortical developmental abnormalities in logopenic variant primary progressive aphasia with dyslexia
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In: Brain Commun (2019)
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Rates of Amyloid Imaging Positivity in Patients With Primary Progressive Aphasia.
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In: JAMA neurology, vol 75, iss 3 (2018)
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Rates of Amyloid Imaging Positivity in Patients With Primary Progressive Aphasia.
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In: JAMA neurology, vol 75, iss 3 (2018)
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Prevalence of Mathematical and Visuospatial Learning Disabilities in Patients With Posterior Cortical Atrophy
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Rates of Amyloid Imaging Positivity in Patients With Primary Progressive Aphasia
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Prevalence of Amyloid-β Pathology in Distinct Variants of Primary Progressive Aphasia
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